Early-stage pilomatricoma with cystic features: A case report and literature review

A conventional pilomatricoma presents as an asymptomatic, firm, subcutaneous nodule, commonly in the head, neck, and extremities of the paediatric population. However, its variants show diverse clinical features, which often pose a diagnostic challenge to clinicians. We recently treated an unusual case of pilomatricoma with cystic features in the upper chest of a 9-year-old girl, which manifested as a single solid tumour floating in a serous-filled sac formed by thick fibrous tissue. Herein, we present novel clinicopathological features of an early-stage pilomatricoma that should be clinically differentiated from a cutaneous abscess

Zinc-copper dual-ion electrolytes to suppress dendritic growth and increase anode utilization in zinc ion capacitors

The main bottlenecks that hinder the performance of rechargeable zinc electrochemical cells are their limited cycle lifetime and energy density. To overcome these limitations, this work studied the mechanism of a dual-ion Zn-Cu electrolyte to suppress dendritic formation and extend the device cycle life while concurrently enhancing the utilization ratio of zinc and thereby increasing the energy density of zinc ion capacitors (ZICs). The ZICs achieved a best-in-class energy density of 41 watt hour per kilogram with a negative-to-positive (n/p) electrode capacity ratio of 3.10. At the n/p ratio of 5.93, the device showed a remarkable cycle life of 22,000 full charge-discharge cycles, which was equivalent to 557 hours of discharge. The cumulative capacity reached ~581 ampere hour per gram, surpassing the benchmarks of lithium and sodium ion capacitors and highlighting the promise of the dual-ion electrolyte for delivering high-performance, low-maintenance electrochemical energy supplies

Geochemical Composition, Source and Geothermometry of Thermal Water in the Bugok Area, South Korea

Thermal water from the hot springs around Bugok, South Korea, has the highest discharge temperature (78 °C), and the source of that heat is of primary interest. The key 3He/4He ratio runs along a single air-mixing line between the mantle and the crust, with the latter accounting for 97.0–97.3%. This suggests that the thermal source is radioactive decay in granodiorite, rock that intruded beneath the Cetaceous era sedimentary rock. Thermal water containing Na–HCO3 (SO4) evolved geochemically from stream water and groundwater containing Ca–HCO3. With respect to δ34S, there are two types of thermal water: low temperature with low δ34S (−3.00~+1.00‰), and high temperature with high δ34S (+4.60~+15.0‰), which is enriched by the kinetic fractionation of H2S. The thermal water samples, except for a few, reached partial chemical equilibrium. The thermal reservoir temperatures were estimated as in the range of 90–126 °C by the K–Mg geothermometer of Giggenbach and the thermodynamic equilibrium of quartz and muscovite. This study suggests a conceptual model for the formation of geothermal water, including the thermal reservoir in the Bugok area

Surface energy-tunable iso decyl acrylate based molds for low pressure-nanoimprint lithography

We presented surface energy-tunable nanoscale molds for unconventional lithography. The mold is highly robust, transparent, has a minimized haze, does not contain additives, and is a non-fluorinated isodecyl acrylate and trimethylolpropane triacrylate based polymer. By changing the mixing ratio of the polymer components, the cross-linking density, mechanical modulus, and surface energy (crucial factors in low pressure ((1-2) x 10(5) N m(-2)) low pressure-nanoimprint lithography (LP-NIL)), can be controlled. To verify these properties of the molds, we also characterized the surface energy by measuring the contact angles and calculating the work of adhesion among the wafer, polymer film, and mold for successful demolding in nanoscale structures. Moreover, the molds showed high optical clarity and precisely tunable mechanical and surface properties, capable of replicating sub-100 nm patterns by thermal LP-NIL and UV-NIL. © 2017 IOP Publishing Ltd Printed in the UK

Aqueous redox flow battery using iron 2,2‐bis(hydroxymethyl)‐2,2′,2′‐nitrilotriethanol complex and ferrocyanide as newly developed redox couple

An all-iron aqueous redox flow battery using iron (Fe) 2,2-bis(hydroxymethyl)-2,2',2'-nitrilotriethanol (BIS-TRIS) complex (Fe(BIS-TRIS)) and Ferrocyanide (Fe[CN](6)) as redox couple is newly suggested. The redox potential of Fe(BIS-TRIS) is -1.11 V (vs Ag/AgCl) and this makes Fe(BIS-TRIS) appropriate as active material for anolyte, while Fe(CN)(6) is proper for catholyte due to its excellent redox reactivity, redox potential, and cheap cost. According to quantitative evaluations, Fe(BIS-TRIS) does not produce any side reactions and is more stable than Fe triethanolamine (TEA) (Fe(TEA)) complex that is conventionally considered for the purpose. This fact is confirmed by computational analysis using density functional theory. In the calculation, energy barrier of Fe(BIS-TR1S) suppressing the occurrence of undesirable side reactions is higher than that of other Fe-ligand complexes, indicating that desirable redox reaction of Fe(BIS-TRIS) occurs more stably. In redox flow battery (RFB) tests, RFBs using Fe(BIS-TRIS) do not show any side reactions even after 250 cycles with excellent performances, such as capacity of 11.7 Ah L-1. and coulombic efficiency and capacity retention rate of 99.8 and 99.9%, respectively. This corroborates that RFBs using Fe(BIS-TRIS) have excellency in both performance and stability, while the cheap cost of BIS-TRIS and Fe(CN)(6) enhances the economic benefit of RFBs.11Nsciescopu

GUI-Enhanced layout generation of FFE SST TXs for fast high-speed serial link design

We present the first FFE SST TX layout generator enhanced by various software techniques including a GUI-based template engine. Seven different DRC/LVS-clean TXs were generated in multiple technologies (40nm/65nm/90nm CMOS) for the first time, and achieved adequate maximum data rates: 36Gb/s with 40nm in post-layout simulation; 14Gb/s with 65nm in measurement. Total generation time was less than 5 days, including iterative parameter tuning by a human designer and computation (30 minutes for TX core, 8 hours for power network). Fast post-layout analysis of TX's performance-power trade-off was enabled by the presented generator for the first time.1

In Vivo Fluorescence Molecular Imaging Using Covalent Organic Nanosheets Without Labeling

Abstract Organic nanomaterials, as nanocarrier platforms, have tremendous potential for biomedical applications. The authors successfully prepared novel two‐dimensional covalent organic nanosheets (CONs) that can be used as efficient in vivo bioimaging probes by condensing 1,3,5‐triformylglucinol (Tp) and 2,7‐diaminopyrene (Py) to produce TpPy covalent organic frameworks (COFs). TpPy COFs are then subjected to a liquid exfoliation process to obtain TpPy CONs (< 200 nm in size and < 1.7 nm in thickness). TpPy CONs disperse well in water to provide a stable, homogeneous colloidal suspension, which shows favorable photoluminescence properties. Cell viability tests using MDA‐MB‐231 and RAW 264.7 cells reveal that TpPy CONs are low in cytotoxicity. Confocal microscopy reveals clear fluorescent cell images after incubation with TpPy CONs for 24 h, without reduction in cell activity or cytosolic aggregation. To investigate the biological behavior of the TpPy CONs, the authors perform an in vivo fluorescence imaging study using MDA‐MB‐231 tumor‐bearing mice. After intravenous injection of TpPy CONs disperse in phosphate‐buffered saline (PBS), persistent and strong fluorescence signals are observed in the tumor region, with low background signals from normal tissues at 1, 3, 12, and 24 h after injection. Furthermore, these in vivo imaging results concurred with ex vivo biodistribution and histological results

Nrg1 engages a crosstalk between Notch and HER3 pathways to promote malignant tumor progression of breast cancer in diabetes

Hyperglycemia is a risk factor for breast cancer-related morbidity and mortality. Hyperglycemia induces Neuregulin 1 (Nrg1) overexpression in breast cancer, and subsequently promotes tumor progression. However, molecular mechanisms underlying Nrg1 overexpression in response to hyperglycemia remain poorly understood. Hyperglycemia altered active histone modifications at the Nrg1 enhancer through histone modifiers, including P300 and SETD1A, causing the open chromatin structure to form enhanceosome complexes where RBPJ, a NOTCH effector, was recruited to upregulate Nrg1 expression. Cells harboring deletions in RBPJ-binding sites showed that hyperglycemia-controlled Nrg1 levels were downregulated, resulting in decreased tumor growth in vitro and in vivo. Streptozotocin-induced hyperglycemia accelerated tumor growth and lapatinib resistance in mice, whereas combining lapatinib with DAPT ameliorated tumor growth under hyperglycemic conditions by inhibiting NOTCH and EGFR superfamilies. NOTCH activity was correlated with NRG1 levels, and high NRG1 levels predicted poor outcomes, particularly in HER2-positive breast cancer patients. Our findings highlight novel impact of hyperglycemia-linked epigenetic modulation of Nrg1 as a potential therapeutic strategy for treating breast cancer patients with diabetes

Dramatically Enhanced Mechanosensitivity and Signal-to-Noise Ratio of Nanoscale Crack-Based Sensors: Effect of Crack Depth

[No abstract available] © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim485