Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus

Measures, completers, and wave of investigations. Figure S1. Controlling for IQ in the final model. Latent factors EF, ToM, ASD, and ADHD were regressed on IQ in the full final model (Figure A), nonsignificant paths were represented by dotted lines. Figure S2. Model including only measures from collected from the adolescents at the age of 14–16 years old. (DOCX 488 kb

The donor conception identity questionnaire: associations with mental health and searching for and finding donor connections

Objective: To understand how the Donor Conception Identity Questionnaire (DCIQ) correlates with mental health and explore differences in the DCIQ between donor conceived people who were actively searching for donor connections to those who were not and those who had found their donor connections to those who had not. Design: Cross-sectional survey. Setting: Online survey conducted within United Kingdom. Patient(s): A total of 88 donor conceived adults ranging in age from 18 to 70 (mean, 34.27 years; median, 31 years). A total of 39 participants were actively searching for their donor connections, and 49 were not. Intervention(s): Donor conception identity was measured using a questionnaire and scores were correlated with existing measures of mental health. Main Outcome Measure(s): Participants completed the DCIQ and measures of well-being, satisfaction with life, identity, pride, and stigma. Result(s): Factor analysis of items from the DCIQ identified four domains: concern and preoccupation; internalized stigma; pride and acceptance; and openness and understanding. The identified factors correlated with scales of psychological and social well-being. Active searchers scored higher than non-active searchers on “concern and preoccupation” and “internalized stigma”. Donor conceived individuals who had found their donor connections scored lower on “internalized stigma” and higher on “openness and understanding” compared with those who had not found their donor connections. Conclusion(s): The findings of the present study show that scores on the DCIQ correlate with existing measures of psychological and social well-being. Furthermore, donor conceived individuals searching for their donor connections differ from those not actively searching on key domains of the DCIQ. Implications for future avenues of study and support for donor conceived people are discussed.</p

Materials from a Workshop on Research Software Management, Sharing and Sustainability held on 20th January 2017

<div>A Workshop on Research Software Management, Sharing and Sustainability was held on 20th January 2017 at Engine Shed, Bristol; hosted by Prof. James Davenport (University of Bath, Software Sustainability Institute Fellow) as part of a national series of workshops funded by Jisc. </div><div>This record holds material from the workshop, including: Workshop Agenda; Slides for a keynote talk from Catherine Jones: "Why is persistently identifying your research software a Good Idea?"*; Slides for a talk from Christopher Woods: "Lessons from Publishing Sire"; Slides for a talk from James Davenport: "Software Management Plans"; Transcripts of feedback from discussion groups facilitated by Zosia Beckles, James Davenport, Catherine Jones and Christopher Woods, transcribed by Richard Evans; Notes on the workshop from James Davenport; Notes on the workshop from Miquel Perello-Nieto.</div><div><br></div><div>*these slides are not included in this record but are available at: http://purl.org/net/epubs/work/31225221</div><div> </div

Additional file 2: Table S1. of Evidence of positive selection associated with placental loss in tiger sharks

Orthologues Under Positive Selection Across All Species. The 95 orthologues exhibiting signatures of positive selection across all species based on the CodeML maximum-likelihood site test and Bayes Empirical Bayes method. (XLSX 29 kb

Additional file 1: Figure S1. of Evidence of positive selection associated with placental loss in tiger sharks

Phylogenetic tree of sharks. Based on analyses of 1,197 genes (1,101,288 bp per species). Species are named along with the orders and families they belong to. ‘Lam.’ refers to Lamniformes order and ‘Tri.’ refers to Triakidae family. The non-placental species are shown in red. Each node is supported with a bootstrap value of 100 %. (PDF 25 kb

Baseline characteristics.

<p>a – by Chi² test for difference between all 3 groups.</p><p>b – Mean (sd).</p><p>c – n (%).</p><p>d – Median (Interquartile range).</p

Longitudinal results in subjects with sepsis.

<p>Note: ADMA = Asymmetric dimethylarginine. RH-PAT index = Reactive hyperaemia peripheral arterial tonometry index. SDMA = Symmetric dimethylarginine. IL-6 = Interleukin 6. SOFA score = Sequential Organ Failure Assessment Score.</p

sj-docx-1-hpp-10.1177_15248399221124596 – Supplemental material for Examining the Relationship Between Existing Community Resources and Community Leaders’ Perceptions of Resilience and Rural Health During COVID-19

Supplemental material, sj-docx-1-hpp-10.1177_15248399221124596 for Examining the Relationship Between Existing Community Resources and Community Leaders’ Perceptions of Resilience and Rural Health During COVID-19 by Abigail Borron, Alison Berg, Catherine Jones, Alexa Lamm, Catherine Sanders, Hannah Southall, Grace Holmes, Courtney Brown, Marsha Davis and Brandy Walker in Health Promotion Practice</p

Ratio of L-arginine to asymmetric dimethylarginine in baseline plasma samples, according to disease category, compared with baseline microvascular reactivity according to disease category.

<p>Panel A shows plasma arginine: ADMA ratio and panel B shows reactive hyperaemia peripheral arterial tonometry index. P values represent comparisons between groups. Solid circles represent individual sepsis subjects and solid triangles represent individual control subjects. Horizontal lines represent median group values, and error bars represent interquartile range. In panel B, solid circles represent mean group values for sepsis subjects, and the solid triangle for control subjects. Error bars represent standard error of the mean.</p

Plasma asymmetric dimethylarginine and related variables at time of initial measurement.

<p>a. median (Interquartile range);</p><p>b. n = septic shock 19, sepsis without shock 37, controls 27;</p><p>c. n (%).</p><p>d. mean (sd).</p