Report on the first phase of the study on men’s usage of the Bradford Health of Men services

This is a summary of the full report on the first year of the HOM project in Bradford, published in March 2005 and available at www.healthofmen.com . In this summary there is a concentration on three things, the background to the project, the experiences of the HOM team in setting up and managing projects and the views of the men involved in the projects. The summary is mostly a list of the things that the team found to be important in setting up projects and, equally important, some of the things not to do. There is, of course, a much fuller discussion of the details of projects, supporting data and the theoretical model of how men and health workers interact to manage health

Training Neurodegenerative Disease Support Group Leaders: A New Support Group Functioning Scale

Support group leaders play pivotal roles in maintaining healthy community support groups; however, these leaders also have personal support needs and typically lack formal training in managing complex behaviors of neurodegenerative disorders. A support group well-being questionnaire, assessing support group functioning, was developed and piloted among participants of an educational training program designed for support group leaders of various neurodegenerative disorder-specific support groups. An exploratory factor analysis evaluated the questionnaire’s psychometric properties and identified a reliable single factor five-item solution, which was titled the Support Group Functioning Scale (SGFS). Preliminary interpretation guidelines were proposed. Development of this scale is a first step in identifying support group leaders’ needs as they provide frontline assistance to caregivers and individuals with neurodegenerative illnesses. This tool shows promise as an efficient way to identify support groups in need of assistance and to assess the impact of trainings on support group functioning. Further validation of the scale is needed

The Bradford & Airedale Health of Men initiative: a study of its effectiveness in engaging with men

The Health of Men (HoM) network received funding from the Big Lottery Fund in 2003 to establish a five year programme of dedicated work with men and boys. This enabled a team of practitioners to be creative and to build upon their existing skills to generate models of working with those men in the community that are usually seen as hard to reach. The research which has accompanied of the work of team has explored why men use these new services and has demonstrated the following: • Men do care about their health • Men are willing and able to engage with their health when services are tailored to their needs • Men from different culture groups and socio-economic backgrounds who are normally seen as hard to reach were accessed. • A model encompassing a dedicated team working with men is worthy of further development Much has been learnt from this project that has great relevance to the local Primary Care Trust (PCT), but has also proved a great source of information for the development of services to men on a Regional, National and International level

Extended Water Quality Monitoring of the Lincoln Lake Watershed

For seven years, the Lincoln Lake (Moores Creek and Beatty Branch) watershed was monitored for improvements in water quality resulting from agricultural best management practices (BMP) implemented to reduce nutrient transport. During the first three years of monitoring (1991 to 1994), nitrogen transport declined significantly (Edwards et al., 1994, 1996, and 1997) under both base and storm flow conditions. This decline in nitrogen transport was again observed in the three-year period following 1994 (Vendrell et al. 1998). This monitoring effort has demonstrated that water quality bas improved in the Lincoln Lake watershed. However, since the nitrogen transport continued to decline and there was some indication that phosphorus may begin to decline, monitoring was extended for another year (1998)

Randomized controlled expressive writing pilot in individuals with Parkinson’s disease and their caregivers

Background Individuals with Parkinson’s disease (PD) and their caregivers are at risk for emotional distress and hypercortisolism. Expressive writing is an effective complementary intervention to ameliorate the psychological and physiological effects of chronic illness. This pilot study aimed to evaluate feasibility and preliminary effectiveness of an expressive writing intervention for individuals with PD and their caregivers. Methods Individuals with PD (N = 27) and their caregivers (N = 14) were randomly assigned to expressive (N = 15 patients, eight caregivers) or neutral (N = 12 patients, six caregivers) writing conditions. Cortisol awakening response (CAR), non-motor functioning, quality of life, and performance on tests of cognitive functioning were assessed at baseline, immediate post, 4-month, and 10-month post intervention. Results Attrition was a challenge as eight patients (29.62 %) and four caregivers (28.57 %) chose to discontinue before beginning the intervention or were lost to follow up prior to completing the intervention or the first follow up visit. Significant reduction in anxiety, marginally significant improvement in depression and caregiver burden, and significant improvements in performance on tests of learning and memory were observed, but these changes did not differ by writing condition. CAR significantly differed over time between patients and caregivers and writing conditions. Conclusions Some evidence for the feasibility and effectiveness of writing to alleviate hypercortisolism was demonstrated in a small sample of PD patients; however, relatively high attrition rates and the lack of difference between expressive and neutral writing conditions on emotional and neurocognitive outcomes suggests expressive writing procedure modifications may be needed to obtain optimal results for this population. Trial registration ClinicalTrials.gov, NCT02217735, Study Start Date: August 30, 2011. Electronic supplementary material The online version of this article (doi:10.1186/s40359-015-0101-4) contains supplementary material, which is available to authorized users. Keywords: Expressive writing, Salivary cortisol, Parkinson’s disease, Quality of life, Caregive

Patient-Reported Needs, Non-Motor Symptoms, and Quality of Life in Essential Tremor and Parkinson’s Disease

Background: Non‐motor symptoms, quality of life, service needs, and barriers to care of individuals with movement disorders are not well explored. This study assessed these domains within a sample of individuals with essential tremor (ET) and Parkinson's disease (PD). Methods: A survey exploring symptoms, needs, and barriers to care was disseminated to a convenience sample (N = 96) of individuals with a primary diagnosis of ET (N = 19) or PD (N = 77). Results: Similarities in overall quality of life and impact on daily functioning were found across individuals with ET and PD. Noteworthy differences included endorsement of different types of service needs and utilization patterns and fewer non‐motor symptoms reported among those with ET (M = 6.1, SD = 2.4) than those with PD (M = 10.4, SD = 3.4). Non‐motor symptoms significantly impacted movement disorder‐related quality of life for both diagnostic groups, but this relationship was stronger for individuals with ET, t(12) = 3.69, p = 0.003, β = 0.73 than with PD, t(56) = 4.00, p less than 0.001, β = 0.47. Individuals with ET also reported higher rates of stigma (31.6% vs. 7.8%) and greater impact of non‐motor symptoms on emotional well‐being, R2 = 0.37, F(1, 13) = 7.17, p = 0.020. Discussion: This is the first study to describe and compare the needs, barriers to care, and impact on quality of life of two distinct movement disorder groups. Our results support the recent efforts of the field to identify interventions to address the non‐motor symptoms of movement disorders and indicate need for greater appreciation of the specific differences in symptoms and quality of life experienced across movement disorder diagnoses

Circumnuclear Gas in Seyfert 1 Galaxies: Morphology, Kinematics, and Direct Measurement of Black Hole Masses

(Abridged) The two-dimensional distribution and kinematics of the molecular, ionized, and highly ionized gas in the nuclear regions of Seyfert 1 galaxies have been measured using high spatial resolution (~0''.09) near-infrared spectroscopy from NIRSPEC with adaptive optics on the Keck telescope. Molecular hydrogen, H2, is detected in all nine Seyfert 1 galaxies and, in the majority of galaxies, has a spatially resolved flux distribution. In contrast, the narrow component of the BrG emission has a distribution consistent with that of the K-band continuum. In general, the kinematics of H2 are consistent with thin disk rotation, with a velocity gradient of over 100 km/s measured across the central 0''.5 in three galaxies, and across the central 1''.5 in two galaxies. The kinematics of BrG are in agreement with the H2 rotation, except in all four cases the central 0''.5 is either blue- or redshifted by more than 75 km/s. The highly ionized gas, measured with the [Ca VIII] and [Si VII] coronal lines, is spatially and kinematically consistent with BrG in the central 0''.5. Dynamical models have been fitted to the two-dimensional H2 kinematics, taking into account the stellar mass distribution, the emission line flux distribution, and the point spread function. For NGC 3227 the modeling indicates a black hole mass of Mbh = 2.0{+1.0/-0.4} x 10^7 Msun, and for NGC 4151 Mbh = 3.0{+0.75/-2.2} x 10^7 Msun. In NGC 7469 the best fit model gives Mbh < 5.0 x 10^7 Msun. In all three galaxies, modeling suggests a near face-on disk inclination angle, which is consistent with the unification theory of active galaxies. The direct black hole mass estimates verify that masses determined from the technique of reverberation mapping are accurate to within a factor of three with no additional systematic errors.Comment: 43 pages, including 47 figures; Accepted for publication in ApJ. All 2-D maps (in high resolution) are available at http://www.astro.ucla.edu/~ehicks . Minor changes to the text and updated reverberation mapped black hole mass estimates; the conclusions are unchange

Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning

AbstractPancreatic exocrine and endocrine lineages arise from multipotent pancreatic progenitor cells (MPCs). Exploiting the mechanisms that govern expansion and differentiation of these cells could enhance efforts to generate β-cells from stem cells. Although our prior work indicates that the canonical Wnt signaling component β-catenin is required qualitatively for exocrine acinar but not endocrine development, precisely how this requirement plays out at the level of MPCs and their lineage-restricted progeny is unknown. In addition, the contribution of β-catenin function to β-cell development remains controversial. To resolve the potential roles of β-catenin in development of MPCs and β-cells, we generated pancreas- and pre-endocrine-specific β-catenin knockout mice. Pancreas-specific loss of β-catenin produced not only a dramatic reduction in acinar cell numbers, but also a significant reduction in β-cell mass. The loss of β-cells is due not to a defect in the differentiation of endocrine precursors, but instead correlates with an early and specific loss of MPCs. In turn, this reflects a novel role for β-catenin in maintaining proximal–distal patterning of the early epithelium, such that distal MPCs resort to a proximal, endocrine-competent “trunk” fate when β-catenin is deleted. Moreover, β-catenin maintains proximal–distal patterning, in part, by inhibiting Notch signaling. Subsequently, β-catenin is required for proliferation of both distal and proximal cells, driving overall organ growth. In distinguishing two distinct roles for β-catenin along the route of β-cell development, we suggest that temporally appropriate positive and negative manipulation of this molecule could enhance expansion and differentiation of stem cell-derived MPCs

Water Quality Sampling, Analysis and Annual Load Determinations for TSS, Nitrogen and Phosphorus in the Bayou Bartholomew at Garrett Bridge, Arkansas and Near Portland, Arkansas

Water quality sampling stations were installed at the Bayou Bartholomew at Garrett Bridge, AR and near Portland, AR. These stations are coordinated with USGS gauging stations at the same locations. These stations are instrumented to collect samples at sufficient intervals across the hydrograph to accurately estimate the flux of total suspended solids, nitrogen and phosphorus in the River. Bayou Bartholomew watershed is about 437,000 hectares and is located in the south east corner of the state. The land use in the watershed is mostly in forest and cropland agriculture with some urban area. High turbidity levels and excessive silt loads in the streams are problems in this watershed. The reason for high turbidity levels and silt loads are thought to be row crop agriculture. Accurate determination of stream nutrients and sediment is critical for future determinations of TMDLs, effectiveness of best management practices and trends in water quality