Additional file 1 of ROR1 and ROR2 expression in pancreatic cancer

Additional file 1 : Supplementary Fig.S1. Correlation between mRNA and protein expression of ROR1 and ROR2 in CPTAC PDAC discovery cohort. A. ROR1 mRNA and protein expression was positively correlated (Pearson’s R=0.25, p=0.005). B. ROR2 mRNA and protein expression was positively correlated (Pearson’s R=0.48, p<0.001)

Supplementary Methods, Figures 1-6 Supplemental Tables 1-2 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors

Supplementary Figure S1. LSTs profiled in this study. Supplementary Figure S2. Mutation validation by Sanger sequencing. Supplementary Figure S3. Analytical strategy for identifying LST driver genes and significantly altered pathways. Supplementary Figure S4. Comparison of methylation events in LSTs and CRCs. Supplementary Figure S5. Epigenetic inactivation of SLITRK5 occurs frequently in LSTs and CRC cell lines. Supplementary Figure S6. Surface morphology and histopathological subtype correlates with the frequency of KRAS mutations. Supplementary Table S1. Clinicopathological characteristics of the eleven LSTs profiled in this study. Supplementary Supplementary Table S2. Clinicopathological characteristics of Validation Cohorts 1 and 2. Supplementary Table S3. Whole exome sequencing data. Supplementary Table S4. Summary of epigenetic and gene expression data.</p

Supplementary Table S3 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors

Somatic mutations identified by WES.</p

Supplementary Table S4 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors

Epigenetically inactivated, upregulated, downregulated and differentially expressed genes.</p