Rotorcraft Blade Angle Calibration Methods

The most vital system of a rotorcraft is the rotor system due to its effects on the overall flight quality of the vehicle. Therefore, it is of importance to be able to accurately determine blade position during flight so that fine adjustments can be made to ensure a safe and efficient flight. In this study, a current calibration method focusing on the pitch, flap, and lead-lag blade angles is analyzed and found to have larger than acceptable error associated with the sensor calibrations. A literature review is conducted which reveals four novel methods that can potentially increase the accuracy of the sensor calibrations. An uncertainty analysis is conducted aiding in the decision of which of the four methods would best improve the calibration accuracy. The results conclude that a simpler method can be applied and calibration times can greatly be reduced while increasing the accuracy of the calibration. Finally, a new calibration method is proposed utilizing the newly chosen sensor that can be later implemented into the system

The impact of Covid-19 restrictions on economic activity: evidence from the Italian regional system

Non-pharmaceutical interventions adopted by governments to halt the spread of Sars-Cov2 are thought to have non-trivial consequences for the economy. The purpose of this paper is to estimate the economic impact of non-pharmaceutical interventions in Italy, by taking advantage of timing differences in their implementation across regions and employing mobility data to proxy activity. To achieve this, we estimate one-way and two-way fixed effects models on a large sample of Italian provinces. We also isolate a set of well-defined quasi-natural experiments in which one region goes from a lower to a higher tier of restrictions, while a neighbouring region remains in the lower tier, for which we can estimate difference-in-differences and continuous treatment models. Moreover, in order to observe whether the impact of restrictions has changed over time, we split the sample around December 2020 and replicate the analysis in each subsample. Our case studies indicate that an Italian province moving from tier 2 to tier 3 in the system of restrictions can expect a fall in mobility of between 12 and 18 percentage points. Thus, we provide evidence of the negative effects of non-pharmaceutical interventions on economic activity. Finally, we provide some evidence that the effectiveness of NPIs in reducing mobility is likely to reduce over time, which has important policy implications. Our estimations are robust to a number of checks

The evolution of flexibility and function in the Fc domains of IgM, IgY, and IgE

IntroductionAntibody Fc regions harbour the binding sites for receptors that mediate effector functions following antigen engagement by the Fab regions. An extended “hinge” region in IgG allows flexibility between Fab and Fc, but in both the most primitive antibody, IgM, and in the evolutionarily more recent IgE, the hinge is replaced by an additional domain pair in the homodimeric six-domain Fc region. This permits additional flexibility within the Fc region, which has been exploited by nature to modulate antibody effector functions. Thus, in pentameric or hexameric IgM, the Fc regions appear to adopt a planar conformation in solution until antigen binding causes a conformational change and exposes the complement binding sites. In contrast, IgE-Fc principally adopts an acutely bent conformation in solution, but the binding of different receptors is controlled by the degree of bending, and there is allosteric communication between receptor binding sites.MethodsWe sought to trace the evolution of Fc conformational diversity from IgM to IgE via the intermediate avian IgY by studying the solution conformations of their Fc regions by small-angle X-ray scattering. We compared four extant proteins: human IgM-Fc homodimer, chicken IgY-Fc, platypus IgE-Fc, and human IgE-Fc. These are examples of proteins that first appeared in the jawed fish [425 million years ago (mya)], tetrapod (310 mya), monotreme (166 mya), and hominid (2.5 mya) clades, respectively.Results and discussionWe analysed the scattering curves in terms of contributions from a pool of variously bent models chosen by a non-negative linear least-squares algorithm and found that the four proteins form a series in which the proportion of acutely bent material increases: IgM-Fc < IgY-Fc < plIgE-Fc < huIgE-Fc. This follows their order of appearance in evolution. For the huIgM-Fc homodimer, although none are acutely bent, and a significant fraction of the protein is sufficiently bent to expose the C1q-binding site, it predominantly adopts a fully extended conformation. In contrast, huIgE-Fc is found principally to be acutely bent, as expected from earlier studies. IgY-Fc, in this first structural analysis of the complete Fc region, exhibits an ensemble of conformations from acutely bent to fully extended, reflecting IgY’s position as an evolutionary intermediate between IgM and IgE

Ar-Ar age constraints on the timing of Havre Trough opening and magmatism

The age and style of opening of the Havre Trough back-arc system is uncertain due to a lack of geochronologic constraints for the region. 40Ar/39Ar dating of 19 volcanic rocks from across the southern Havre Trough and Kermadec Arc was conducted in three laboratories to provide age constraints on the system. The results are integrated and interpreted as suggesting that this subduction system is young (<2 Ma) and coeval with opening of the continental Taupo Volcanic Zone of New Zealand. Arc magmatism was broadly concurrent across the breadth of the Havre Trough

Vertebrate Host Susceptibility to Heartland Virus

Heartland virus (HRTV) is a recently described phlebovirus initially isolated in 2009 from 2 humans who had leukopenia and thrombocytopenia. Serologic assessment of domestic and wild animal populations near the residence of 1 of these persons showed high exposure rates to raccoons, white-tailed deer, and horses. To our knowledge, no laboratory-based assessments of viremic potential of animals infected with HRTV have been performed. We experimentally inoculated several vertebrates (raccoons, goats, chickens, rabbits, hamsters, C57BL/6 mice, and interferon-α/β/γ receptor–deficient [Ag129]) mice with this virus. All animals showed immune responses against HRTV after primary or secondary exposure. However, neutralizing antibody responses were limited. Only Ag129 mice showed detectable viremia and associated illness and death, which were dose dependent. Ag129 mice also showed development of mean peak viral antibody titers \u3e8 log10 PFU/mL, hemorrhagic hepatic lesions, splenomegaly, and large amounts of HRTV antigen in mononuclear cells and hematopoietic cells in the spleen

Blood and MRI biomarkers of mild traumatic brain injury in non-concussed collegiate football players

Football has one of the highest incidence rates of mild traumatic brain injury (mTBI) among contact sports; however, the effects of repeated sub-concussive head impacts on brain structure and function remain under-studied. We assessed the association between biomarkers of mTBI and structural and functional MRI scans over an entire season among non-concussed NCAA Division I linemen and non-linemen. Concentrations of S100B, GFAP, BDNF, NFL, and NSE were assessed in 48 collegiate football players (32 linemen; 16 non-linemen) before the start of pre-season training (pre-camp), at the end of pre-season training (pre-season), and at the end of the competitive season (post-season). Changes in brain structure and function were assessed in a sub-sample of 11 linemen and 6 non-linemen using structural and functional MRI during the execution of Stroop and attention network tasks. S100B, GFAP and BDNF concentrations were increased at post-season compared to pre-camp in linemen. White matter hyperintensities increased in linemen during pre-season camp training compared to pre-camp. This study showed that the effects of repeated head impacts are detectable in the blood of elite level non-concussed collegiate football players exposed to low-moderate impacts to the heads, which correlated with some neurological outcomes without translating to clinically-relevant changes in brain anatomy or function

Adenovirus Type 7 causing severe lower respiratory tract infection in immunocompetent adults: a comparison of two contrasting cases from an intensive care unit in North West England

Objectives: Severe lower respiratory tract infection caused by adenovirus is well described in immunocompromised hosts and can cause significant morbidity and mortality. We compare and contrast the clinical presentation, radiological, and virological features of two rare cases in immunocompetent adults admitted to an intensive care unit in a large, teaching hospital in North West England. We then provide a concise, comprehensive literature review. Methods: The first casewas a 35-year old female asthmaticwho presentedwith respiratory distress and pneumonitis during peak influenza season, and recovered after a prolonged hospital stay. The second case was a 73-year old male who presented with diarrhoea, vomiting, and general malaise outside of influenza season, developed respiratory compromise, and died. Adenovirus type 7 was identified in bronchoalveolar lavages and plasma samples of both patients, each of whom received cidofovir. No other infectious aetiology was identified. Results: Clinical and radiological features of severe lower respiratory tract adenoviral infection are similar to other infectious causes of pneumonia and ARDS, including severe influenza. This can create diagnostic uncertainty, especially during influenza season. Positive adenovirus polymerase chain reaction results can support a diagnosis of severe lower respiratory tract adenovirus infection in patients with a clinically compatible syndrome and no other identified aetiology, with higher viral loads being associated with worse prognosis. Although treatment is predominantly supportive, early use of cidofovir may improve outcomes. Conclusions: These rare cases highlight that severe lower respiratory tract adenoviral infection should be considered in the differential diagnoses of immunocompetent patients presenting with pneumonia and ARDS

Salivary Immunity Of Elite Collegiate American Football Players Infected With Sars-cov-2 Normalizes Following Isolation

The impact of COVID-19 on systemic immunity in the general population has been well characterized, however the short-term effects of COVID-19 infection on innate salivary immunity in elite-level athletes are unknown. Therefore, this study aimed to determine whether elite college football athletes had altered salivary immunity following the CDC-recommended isolation post-SARS-CoV-2 infection. Salivary samples were obtained from fourteen elite football players who tested positive for SARS-CoV-2 (n = 14), immediately after CDC-recommended isolation (average days = 14 ± 2 days) and fifteen controls who remained uninfected with SARS-CoV-2. Biomarkers of innate salivary immunity (sIgA and alpha-amylase), antimicrobial proteins (AMPs, i.e., HNP1-3, lactoferrin, LL-37) and lung inflammation (SPA, SPLI, and Neutrophil Elastase-alpha-1-antitrypsin complex) were measured. Independent student t-tests were used to determine changes in biomarkers between groups. Although all AMP levels were within normal range, Human Neutrophil Defensin 1–3 concentrations and secretion rates were higher in SARS-CoV-2+ compared to SARS-CoV-2–. This suggests that the CDC-recommended isolation period is sufficient to ensure that athletes’ salivary immunity is not compromised upon return to sports, and athletes post-COVID-19 infection do not appear to be at greater risk for secondary infection than those with no history of COVID-19

Heterogeneous seismic velocity structure of the upper lithosphere at Kane oceanic core complex, Mid-Atlantic Ridge

Author Posting. © American Geophysical Union, 2009. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 10 (2009): Q10001, doi:10.1029/2009GC002586.The Kane oceanic core complex (OCC) is a large, corrugated megamullion that was formed by a long-lived detachment fault at the axis of the Mid-Atlantic Ridge adjacent to Kane Fracture Zone between 2.1 and 3.3 Ma. We use refracted arrivals recorded along a 6-km-long hydrophone streamer during a multichannel seismic survey to constrain the shallow seismic velocity structure of the OCC. Results are presented in high-resolution traveltime seismic tomographic models along six lines that cover all of the main morphological features of the megamullion. The models show large lateral variability in P wave velocity within the upper ∼0.5–2.0 km of the lithosphere, and these variations correlate to first order with observed variations in lithology, documented by in situ basement samples and seafloor morphology. Lithological interpretation of the velocity models indicates that there is marked lateral variability in distribution of gabbroic intrusions, serpentinized peridotites, and basalts at scales of a few kilometers to ∼10 km. Serpentinized peridotites appear to dominate the central and older parts of the OCC. High-velocity gabbros are consistently (but not exclusively) present closer to the termination of the Kane detachment fault and toward the ends of the OCC. The structure of the lithosphere exhumed by the Kane detachment fault is far from the standard ophiolite-based Penrose model, and it does not show segment-centered magmatism that is commonly interpreted at slow spreading ridges. If the gabbros exhumed toward the termination of the OCC were emplaced deep (∼10 km) beneath the spreading axis, they may have constituted a weak zone that focused initiation of the Kane detachment fault. Alternately, as the OCC footwall was being exhumed the gabbros may have been emplaced because of dynamic changes in melt supply, changes in mantle fertility, or decompression melting. Late stage volcanism is clearly associated with a major high-angle normal fault that cuts the detachment surface; this volcanism may have been stimulated or enhanced by bending stresses in the bending footwall. The shape of the large-scale corrugated morphology of the OCC is nearly invariant in the dip direction across major changes in basement lithology, indicating that once established, the form of the Kane detachment fault was highly resistant to modification.This research was supported by NSF grants OCE-9987004 and OCE-0621660