Protein-mediated dethreading of a biotin-functionalised pseudorotaxane

In this article, we describe the synthesis of new biotin-functionalised naphthalene derivatives 3 and 4 and their complexation behaviour with avidin and neutravidin using a range of analytical techniques. We have shown using 2-(4prime or minute-hydroxyazobenzene)benzoic acid displacement and ITC experiments{,} that compounds 3 and 4 have the propensity to form reasonably high-affinity bioconjugates with avidin and neutravidin. We have also demonstrated using 1H NMR{,} UV-vis and fluorescence spectroscopy that the naphthalene moiety of 3 and 4 facilitates the formation of pseudorotaxane-like structures with 1 in water. We have then investigated the ability of avidin and neutravidin to modulate the complexation between 1 and 3 or 4. UV-vis and fluorescence spectroscopy has shown that in both cases the addition of the protein disrupts complexation between the naphthalene moieties of 3 and 4 with 1

The distribution of transit durations for Kepler planet candidates and implications for their orbital eccentricities

‘In these times, during the rise in the popularity of institutional repositories, the Society does not forbid authors from depositing their work in such repositories. However, the AAS regards the deposit of scholarly work in such repositories to be a decision of the individual scholar, as long as the individual's actions respect the diligence of the journals and their reviewers.’ Original article can be found at : http://iopscience.iop.org/ Copyright American Astronomical SocietyDoppler planet searches have discovered that giant planets follow orbits with a wide range of orbital eccentricities, revolutionizing theories of planet formation. The discovery of hundreds of exoplanet candidates by NASA's Kepler mission enables astronomers to characterize the eccentricity distribution of small exoplanets. Measuring the eccentricity of individual planets is only practical in favorable cases that are amenable to complementary techniques (e.g., radial velocities, transit timing variations, occultation photometry). Yet even in the absence of individual eccentricities, it is possible to study the distribution of eccentricities based on the distribution of transit durations (relative to the maximum transit duration for a circular orbit). We analyze the transit duration distribution of Kepler planet candidates. We find that for host stars with T > 5100 K we cannot invert this to infer the eccentricity distribution at this time due to uncertainties and possible systematics in the host star densities. With this limitation in mind, we compare the observed transit duration distribution with models to rule out extreme distributions. If we assume a Rayleigh eccentricity distribution for Kepler planet candidates, then we find best fits with a mean eccentricity of 0.1-0.25 for host stars with T ≤ 5100 K. We compare the transit duration distribution for different subsets of Kepler planet candidates and discuss tentative trends with planetary radius and multiplicity. High-precision spectroscopic follow-up observations for a large sample of host stars will be required to confirm which trends are real and which are the results of systematic errors in stellar radii. Finally, we identify planet candidates that must be eccentric or have a significantly underestimated stellar radius.Peer reviewedFinal Accepted Versio

Implications of partially degenerate neutrinos at a high scale in the light of KamLAND and WMAP

Electroweak radiative corrections can generate the neutrino (mass)$^2$ difference required for the large mixing angle solution (LMA) to the solar neutrino problem if two of the neutrinos are assumed degenerate at high energy. We test this possibility with the existing experimental knowledge of the low energy neutrino mass and mixing parameters. We derive restrictions on ranges of the high scale mixing matrix elements and obtain predictions for the low energy parameters required in order to get the LMA solution of the solar neutrino problem picked out by KamLAND. We find that in the case of standard model this is achieved only when the (degenerate) neutrino masses lie in the range (0.7-2) \eV which is at odds with the cosmological limit m_{\nu}<0.23 \eV (at $95$) established recently using WMAP results. Thus SM radiative corrections cannot easily generate the LMA solution in this scenario. However, the LMA solution is possible in case of the MSSM electroweak corrections with (almost) degenerate spectrum or with inverted mass hierarchy for limited ranges in the high scale parameters.Comment: 15 pages, LATEX includes five postscript figure

Neutrinoless Double Beta Decay and the Solar Neutrino Problem

The MSW or vacuum oscillation solution of the solar neutrino problem can be reconciled with possible existence of the $(\beta\beta)_{0\nu}$ decay with a half-life corresponding to an effective Majorana mass of the electron neutrino $|m_{ee}| \cong (0.1 - 1.0)~$eV. The phenomenological consequences of such a possibility are analyzed and the implications for the mechanisms of neutrino mass generation are considered.Comment: 17 pages (2 figures available upon request), LaTeX, SISSA 113/93/EP and IC/93/360 (the word BETA inserted in the title

Planck-Scale Physics and Neutrino Masses

We discuss gravitationally induced masses and mass splittings of Majorana, Zeldovich-Konopinski-Mahmoud and Dirac neutrinos. Among other implications, these effects can provide a solution of the solar neutrino puzzle. In particular, we show how this may work in the 17 keV neutrino picture.Comment: 10 pages, IC/92/79, SISSA-83/92/EP, LMU-04/92 (the preprint number has been corrected; no other changes

Neutrino oscillation constraints on neutrinoless double beta decay

We have studied the constraints imposed by the results of neutrino oscillation experiments on the effective Majorana mass || that characterizes the contribution of Majorana neutrino masses to the matrix element of neutrinoless double-beta decay. We have shown that in a general scheme with three Majorana neutrinos and a hierarchy of neutrino masses (which can be explained by the see-saw mechanism), the results of neutrino oscillation experiments imply rather strong constraints on the parameter ||. From the results of the first reactor long-baseline experiment CHOOZ and the Bugey experiment it follows that || < 3x10^{-2} eV if the largest mass-squared difference is smaller than 2 eV^2. Hence, we conclude that the observation of neutrinoless double-beta decay with a probability that corresponds to || > 10^{-1} eV would be a signal for a non-hierarchical neutrino mass spectrum and/or non-standard mechanisms of lepton number violation.Comment: 20 pages, including 4 figure

Global Analysis with SNO: Toward the Solution of the Solar Neutrino Problem

We perform a global analysis of the latest solar neutrino data including the SNO result on the CC-event rate. This result further favors the LMA solution of the solar neutrino problem. The best fit values of parameters we find are: \Delta m^2 = (4.8 - 5.0)10^{-5} eV^2, tan^2 \theta = 0.35 - 0.38, f_B = 1.08 - 1.12, and f_{hep} = 1 - 4. With respect to this best fit the LOW solution is accepted at 90% C.L.. The Vacuum oscillation solution with \Delta m^2 = 1.4 10^{-10} eV^2, gives good fit of the data provided that the boron neutrino flux is substantially smaller than the SSM flux (f_B \sim 0.5). The SMA solution is accepted only at 3\sigma level. We find that vacuum oscillations to sterile neutrino, VAC(sterile), with f_B \sim 0.5 also give rather good global fit of the data. All other sterile solutions are strongly disfavored. We check the quality of the fit by constructing the pull-off diagrams of observables. Predictions for the day-night asymmetry, spectrum distortion and NC/CC ratio at SNO are calculated. In the best fit points of the global solutions we find: A_{DN}^{CC} \approx (7 - 8)% for LMA, \sim 3% for LOW, and (2 - 3)% for SMA. It will be difficult to see the distortion of the spectrum expected for LMA as well as LOW solutions. However, future SNO spectral data can significantly affect the VAC and SMA solutions. We also calculate expectations for the BOREXINO rate.Comment: 35 pages, latex, 9 figures; results of analysis slightly changed due to different treatment of the hep neutrino flux; predictions for NC/CC ratio and Borexino rate adde

Observational Constraints on Chaplygin Quartessence: Background Results

We derive the constraints set by several experiments on the quartessence Chaplygin model (QCM). In this scenario, a single fluid component drives the Universe from a nonrelativistic matter-dominated phase to an accelerated expansion phase behaving, first, like dark matter and in a more recent epoch like dark energy. We consider current data from SNIa experiments, statistics of gravitational lensing, FR IIb radio galaxies, and x-ray gas mass fraction in galaxy clusters. We investigate the constraints from this data set on flat Chaplygin quartessence cosmologies. The observables considered here are dependent essentially on the background geometry, and not on the specific form of the QCM fluctuations. We obtain the confidence region on the two parameters of the model from a combined analysis of all the above tests. We find that the best-fit occurs close to the $\Lambda$CDM limit ($\alpha=0$). The standard Chaplygin quartessence ($\alpha=1$) is also allowed by the data, but only at the $\sim2\sigma$ level.Comment: Replaced to match the published version, references update

Kepler-22b: A 2.4 Earth-radius Planet in the Habitable Zone of a Sun-like Star

A search of the time-series photometry from NASA's Kepler spacecraft reveals a transiting planet candidate orbiting the 11th magnitude G5 dwarf KIC 10593626 with a period of 290 days. The characteristics of the host star are well constrained by high-resolution spectroscopy combined with an asteroseismic analysis of the Kepler photometry, leading to an estimated mass and radius of 0.970 +/- 0.060 MSun and 0.979 +/- 0.020 RSun. The depth of 492 +/- 10ppm for the three observed transits yields a radius of 2.38 +/- 0.13 REarth for the planet. The system passes a battery of tests for false positives, including reconnaissance spectroscopy, high-resolution imaging, and centroid motion. A full BLENDER analysis provides further validation of the planet interpretation by showing that contamination of the target by an eclipsing system would rarely mimic the observed shape of the transits. The final validation of the planet is provided by 16 radial velocities obtained with HIRES on Keck 1 over a one year span. Although the velocities do not lead to a reliable orbit and mass determination, they are able to constrain the mass to a 3{\sigma} upper limit of 124 MEarth, safely in the regime of planetary masses, thus earning the designation Kepler-22b. The radiative equilibrium temperature is 262K for a planet in Kepler-22b's orbit. Although there is no evidence that Kepler-22b is a rocky planet, it is the first confirmed planet with a measured radius to orbit in the Habitable Zone of any star other than the Sun.Comment: Accepted to Ap

Neutrinoless double-beta decay with three or four neutrino mixing

Considering the scheme with mixing of three neutrinos and a mass hierarchy that can accommodate the results of solar and atmospheric neutrino experiments, it is shown that the results of solar neutrino experiments imply a lower bound for the effective Majorana mass in neutrinoless double-beta decay, under the natural assumptions that massive neutrinos are Majorana particles and there are no unlikely fine-tuned cancellations among the contributions of the different neutrino masses. Considering the four-neutrino schemes that can accommodate also the results of the LSND experiment, it is shown that only one of them is compatible with the results of neutrinoless double-beta decay experiments and with the measurement of the abundances of primordial elements produced in Big-Bang Nucleosynthesis. It is shown that in this scheme, under the assumptions that massive neutrinos are Majorana particles and there are no cancellations among the contributions of the different neutrino masses, the results of the LSND experiment imply a lower bound for the effective Majorana mass in neutrinoless double-beta decay.Comment: 18 pages including 2 figures, RevTe