4 research outputs found

    "La llave" una perversidad cinematogr√°fica de Josefina Vicens

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    _En el presente trabajo se da cuenta de la labor que desempe√Ī√≥ Josefina Vicens en la industria cinematogr√°fica, a la par de su labor como escritora. En este medio se desempe√Ī√≥ durante un largo periodo en el que intervino en diversas producciones

    Virginia Aguirre una cuenta pendiente

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    Ensayo memorialístico que oborda la labor de Virginia Aguirre  como editora de la revista La Colmena  y, principalmente, como promotora cultural

    El cine mexicano de la edad de oro y su impacto internacional

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    A partir de una investigación documental en publicaciones periódicas de Argentina, Colombia, Cuba, Chile, Estados Unidos, Honduras, México, Nicaragua y Venezuela, este artículo demuestra el interés que el cine mexicano producido entre 1936 y 1956 provocó en los espectadores de Hispanoamérica y Estados Unidos, al igual que la presencia de actores, cineastas, temas y personajes de otros países hispanohablantes en la industria cinematográfica mexicana durante la denominada edad de oro del cine mexicano. Se constató la influencia de este cine en la conformación de la identidad cultural de los mexicanos y su proyección internacional

    Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

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    Background: Additional safe and efficacious vaccines are needed to control the COVID-19 pandemic. We aimed to analyse the efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate. Methods: HERALD is a randomised, observer-blinded, placebo-controlled, phase 2b/3 clinical trial conducted in 47 centres in ten countries in Europe and Latin America. By use of an interactive web response system and stratification by country and age group (18‚Äď60 years and ‚Č•61 years), adults with no history of virologically confirmed COVID-19 were randomly assigned (1:1) to receive intramuscularly either two 0¬∑6 mL doses of CVnCoV containing 12 őľg of mRNA or two 0¬∑6 mL doses of 0¬∑9% NaCl (placebo) on days 1 and 29. The primary efficacy endpoint was the occurrence of a first episode of virologically confirmed symptomatic COVID-19 of any severity and caused by any strain from 15 days after the second dose. For the primary endpoint, the trial was considered successful if the lower limit of the CI was greater than 30%. Key secondary endpoints were the occurrence of a first episode of virologically confirmed moderate-to-severe COVID-19, severe COVID-19, and COVID-19 of any severity by age group. Primary safety outcomes were solicited local and systemic adverse events within 7 days after each dose and unsolicited adverse events within 28 days after each dose in phase 2b participants, and serious adverse events and adverse events of special interest up to 1 year after the second dose in phase 2b and phase 3 participants. Here, we report data up to June 18, 2021. The study is registered at ClinicalTrials.gov, NCT04652102, and EudraCT, 2020‚Äď003998‚Äď22, and is ongoing. Findings: Between Dec 11, 2020, and April 12, 2021, 39 680 participants were enrolled and randomly assigned to receive either CVnCoV (n=19 846) or placebo (n=19 834), of whom 19 783 received at least one dose of CVnCoV and 19 746 received at least one dose of placebo. After a mean observation period of 48¬∑2 days (SE 0¬∑2), 83 cases of COVID-19 occurred in the CVnCoV group (n=12 851) in 1735¬∑29 person-years and 145 cases occurred in the placebo group (n=12 211) in 1569¬∑87 person-years, resulting in an overall vaccine efficacy against symptomatic COVID-19 of 48¬∑2% (95¬∑826% CI 31¬∑0‚Äď61¬∑4; p=0¬∑016). Vaccine efficacy against moderate-to-severe COVID-19 was 70¬∑7% (95% CI 42¬∑5‚Äď86¬∑1; CVnCoV 12 cases in 1735¬∑29 person-years, placebo 37 cases in 1569¬∑87 person-years). In participants aged 18‚Äď60 years, vaccine efficacy against symptomatic disease was 52¬∑5% (95% CI 36¬∑2‚Äď64¬∑8; CVnCoV 71 cases in 1591¬∑47 person-years, placebo, 136 cases in 1449¬∑23 person-years). Too few cases occurred in participants aged 61 years or older (CVnCoV 12, placebo nine) to allow meaningful assessment of vaccine efficacy. Solicited adverse events, which were mostly systemic, were more common in CVnCoV recipients (1933 [96¬∑5%] of 2003) than in placebo recipients (1344 [67¬∑9%] of 1978), with 542 (27¬∑1%) CVnCoV recipients and 61 (3¬∑1%) placebo recipients reporting grade 3 solicited adverse events. The most frequently reported local reaction after any dose in the CVnCoV group was injection-site pain (1678 [83¬∑6%] of 2007), with 22 grade 3 reactions, and the most frequently reported systematic reactions were fatigue (1603 [80¬∑0%] of 2003) and headache (1541 [76¬∑9%] of 2003). 82 (0¬∑4%) of 19 783 CVnCoV recipients reported 100 serious adverse events and 66 (0¬∑3%) of 19 746 placebo recipients reported 76 serious adverse events. Eight serious adverse events in five CVnCoV recipients and two serious adverse events in two placebo recipients were considered vaccination-related. None of the fatal serious adverse events reported (eight in the CVnCoV group and six in the placebo group) were considered to be related to study vaccination. Adverse events of special interest were reported for 38 (0¬∑2%) participants in the CVnCoV group and 31 (0¬∑2%) participants in the placebo group. These events were considered to be related to the trial vaccine for 14 (<0¬∑1%) participants in the CVnCoV group and for five (<0¬∑1%) participants in the placebo group. Interpretation: CVnCoV was efficacious in the prevention of COVID-19 of any severity and had an acceptable safety profile. Taking into account the changing environment, including the emergence of SARS-CoV-2 variants, and timelines for further development, the decision has been made to cease activities on the CVnCoV candidate and to focus efforts on the development of next-generation vaccine candidates. Funding: German Federal Ministry of Education and Research and CureVac
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