209 research outputs found
Impacts of Giving Circles on Participants: Giving Style and Civic Engagement
Giving circles are an emerging form of philanthropy in which members contribute and pool funding with the intent to distribute said funding to grantees, with such efforts often identified based on group-generated consensus with members voting on both what issues to address and which recipients to fund, in order to generate an increased impact on the grantee. Giving circles present a way in which individuals may exert greater control over the way in which their donations are appropriated without needing to donate relatively large sums of money. In this way giving circles may present an attractive option to individuals who may be new to the process of philanthropy or may wish to focus their philanthropic efforts on specific causes or issues. Giving circle participation may also provide an opportunity for hands-on engagement of members through the ability to identify potential recipients and participate in the process of researching and potentially funding such projects or organizations. The research project aims to assess the impact of an individual\u27s participation in a philanthropic giving circle with regards to their philanthropic behavior and civic engagement. The researchers of this project posit that participation in giving circles leads to sustained habits of philanthropy which emphasize greater donor control and participation than traditional philanthropic methods. The project also aims to explore how the socialization aspect of giving circles affects philanthropic habits. In a society which is seeing increasing awareness of civic participation by individuals, giving circles may present a way for people and groups to further engage with causes or issues important to them and this project aims to explore potential connections between giving circles and other forms of civic engagement such as volunteerism or participation in the political process. Such participation may be a tool for increasing such engagement of members or may simply be an existing trait present in individuals who are drawn to the giving circle method. Over the course of this project, consenting members of Virginia-based giving circles will complete an online survey assessing their philanthropic habits, civic engagement habits, attitudes and motivations regarding individual giving style, and key demographic qualities. Consenting participants will also participate in one-on-one interviews that allow for more in-depth exploration of these themes. Such participants will be recruited through email and phone based outreach to respective giving circle coordinators. When feasible, the research team will visit giving circle meetings to further explain the project and answer questions. Through these efforts the research team will contribute to the knowledge of the field of philanthropy regarding the phenomena of giving circles which may then be shared through academic channels such as peer-reviewed journals and participation in appropriate conferences
Analysis of Sea Ice Roughness and Thickness Variation for Improvement of SAR Ice Type Classification
Sea ice local surface topography from single-pass satellite InSAR measurements: a feasibility study
Quantitative parameters characterizing the sea ice surface topography are needed in geophysical investigations
such as studies on atmosphere–ice interactions or sea ice mechanics.Recently, the use of space-borne single-pass interferometric synthetic aperture radar (InSAR) for retrieving the ice surface topography has attracted notice among geophysicists. In this paper the potential of InSAR measurements is examined for several satellite configurations and radar frequencies, considering statistics of heights and widths of ice
ridges as well as possible magnitudes of ice drift. It is shown that, theoretically, surface height variations can be retrievedwith relative errors < 0.5 m. In practice, however, the sea ice drift and open water leads may contribute significantly to the measured interferometric phase. Another essential factor is
the dependence of the achievable interferometric baseline on the satellite orbit configurations. Possibilities to assess the influence of different factors on the measurement accuracy are demonstrated: signal-to-noise ratio, presence of a snow layer, and the penetration depth into the ice. Practical examples of
sea surface height retrievals from bistatic SAR images collectedduring the TanDEM-X Science Phase are presented
Optimal Detection for Diffusion-Based Molecular Timing Channels
This work studies optimal detection for communication over diffusion-based
molecular timing (DBMT) channels. The transmitter simultaneously releases
multiple information particles, where the information is encoded in the time of
release. The receiver decodes the transmitted information based on the random
time of arrival of the information particles, which is modeled as an additive
noise channel. For a DBMT channel without flow, this noise follows the L\'evy
distribution. Under this channel model, the maximum-likelihood (ML) detector is
derived and shown to have high computational complexity. It is also shown that
under ML detection, releasing multiple particles improves performance, while
for any additive channel with -stable noise where (such as
the DBMT channel), under linear processing at the receiver, releasing multiple
particles degrades performance relative to releasing a single particle. Hence,
a new low-complexity detector, which is based on the first arrival (FA) among
all the transmitted particles, is proposed. It is shown that for a small number
of released particles, the performance of the FA detector is very close to that
of the ML detector. On the other hand, error exponent analysis shows that the
performance of the two detectors differ when the number of released particles
is large.Comment: 16 pages, 9 figures. Submitted for publicatio
Monitoring the Petermann Ice Island with TanDEM-X
This paper presents the processing of TanDEM-X acquisitions for the monitoring of the topography of the Petermann ice island. In this particular case the area under study is continuously moving and the acquisition geometry is changing, so the processing of the iceberg’s DEMs is challenging and additional effects are to be considered. The SAR processing chain used is presented and the results obtained summarized, showing the effects and limitations observed during the process
A radiological assessment of nuclear power and propulsion operations near Space Station Freedom
Scenarios were identified which involve the use of nuclear power systems in the vicinity of Space Station Freedom (SSF) and their radiological impact on the SSF crew was quantified. Several of the developed scenarios relate to the use of SSF as an evolutionary transportation node for lunar and Mars missions. In particular, radiation doses delivered to SSF crew were calculated for both the launch and subsequent return of a Nuclear Electric Propulsion (NEP) cargo vehicle and a Nuclear Thermal Rocket (NTR) personnel vehicle to low earth orbit. The use of nuclear power on co-orbiting platforms and the storage and handling issues associated with radioisotope power systems were also explored as they relate to SSF. A central philosophy in these analyses was the utilization of a radiation dose budget, defined as the difference between recommended dose limits from all radiation sources and estimated doses received by crew members from natural space radiations. Consequently, for each scenario examined, the dose budget concept was used to identify and quantify constraints on operational parameters such as launch separation distances, returned vehicle parking distances, and reactor shutdown times prior to vehicle approach. The results indicate that realistic scenarios do not exist which would preclude the use of nuclear power sources in the vicinity of SSF. The radiation dose to the SSF crew can be maintained at safe levels solely by implementing proper and reasonable operating procedures
Ligating Catalytically Active Peptides onto Microporous Polymers: A General Route Toward Specifically-Functional High Surface Area Platforms
A versatile post-synthetic modification strategy to functionalize a high surface area microporous network (MPN-OH) by bio-orthogonal inverse electron-demand Diels-Alder (IEDDA) ligation is presented. While the polymer matrix is modified with a readily accessible norbornene isocyanate (Nor-NCO), a series of functional units presenting the robust asymmetric 1,2,4,5-tetrazine (Tz) allows easy functionalization of the MPN by chemoselective Nor/Tz ligation. A generic route is demonstrated, modulating the internal interfaces by introducing carboxylates, amides or amino acids as well as an oligopeptide d-Pro-Pro-Glu organocatalyst. The MPN-Pz-Peptide construct largely retains the catalytic activity and selectivity in an enantioselective enamine catalysis, demonstrates remarkable availability in different solvents, offers heterogeneous organocatalysis in bulk and shows stability in recycling settings.Peer Reviewe
Enhancing stability of recombinant CHO cells by CRISPR/Cas9-mediated site-specific integration into regions with distinct histone modifications
Chinese hamster ovary (CHO) cells are the most important platform for producing biotherapeutics. Random integration of a transgene into epigenetically instable regions of the genome results in silencing of the gene of interest and loss of productivity during upstream processing. Therefore, cost- and time-intensive long-term stability studies must be performed. Site-specific integration into safe harbors is a strategy to overcome these limitations of conventional cell line design. Recent publications predict safe harbors in CHO cells based on omics data sets or by learning from random integrations, but those predictions remain theory. In this study, we established a CRISPR/Cas9-mediated site-specific integration strategy based on ChIP-seq data to improve stability of recombinant CHO cells. Therefore, a ChIP experiment from the exponential and stationary growth phase of a fed-batch cultivation of CHO-K1 cells yielded 709 potentially stable integration sites. The reporter gene eGFP was integrated into three regions harboring specific modifications by CRISPR/Cas9. Targeted Cas9 nanopore sequencing showed site-specific integration in all 3 cell pools with a specificity between 23 and 73%. Subsequently, the cells with the three different integration sites were compared with the randomly integrated donor vector in terms of transcript level, productivity, gene copy numbers and stability. All site-specific integrations showed an increase in productivity and transcript levels of up to 7.4-fold. In a long-term cultivation over 70 generations, two of the site-specific integrations showed a stable productivity (>70%) independent of selection pressure
Ferromagnetic Luttinger Liquids
We study weak itinerant ferromagnetism in one-dimensional Fermi systems using
perturbation theory and bosonization. We find that longitudinal spin
fluctuations propagate ballistically with velocity v_m << v_F, where v_F is the
Fermi velocity. This leads to a large anomalous dimension in the spin-channel
and strong algebraic singularities in the single-particle spectral function and
in the transverse structure factor for momentum transfers q ~ 2 Delta/v_F,
where 2 Delta is the exchange splitting.Comment: 4 pages, 3 figure
Iceberg topography and volume classification using TanDEM-X interferometry
Icebergs in polar regions affect water salinity, alter marine habitats, and impose serious hazards on maritime operations and navigation. These impacts mainly depend on the iceberg volume, which remains an elusive parameter to measure. We investigate the capability of TanDEM-X bistatic single-pass synthetic aperture radar interferometry (InSAR) to derive iceberg subaerial morphology and infer total volume. We cross-verify InSAR results with Operation IceBridge (OIB) data acquired near Wordie Bay, Antarctica, as part of the OIB/TanDEM-X Antarctic Science Campaign (OTASC). While icebergs are typically classified according to size based on length or maximum height, we develop a new volumetric classification approach for applications where iceberg volume is relevant. For icebergs with heights exceeding 5 m, we find iceberg volumes derived from TanDEM-X and OIB data match within 7 %. We also derive a range of possible iceberg keel depths relevant to grounding and potential impacts on subsea installations. These results suggest that TanDEM-X could pave the way for future single-pass interferometric systems for scientific and operational iceberg mapping and classification based on iceberg volume and keel depth
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