The variational slope of quasar light curves is not a distance indicator

When the time difference quotients, or \emph{variational slopes}, of quasar light curves are plotted against their absolute magnitudes, there is a tight positive correlation of $\sim 0.16$ dex in the variational slope direction or $\sim 0.5$ dex in the absolute magnitude direction. This finding resulted in suggestions that a variational slope -- luminosity relation could be used as a distance indicator. However, I show that this relation can be explained almost entirely from self-correlation with luminosity. After properly accounting for the self-correlation component, the relation has a true scatter of $\sim 1.5$ dex in luminosity, consistent with established correlations for quasar variability amplitudes. Given this large scatter, correlation with variational slope or variability amplitude and luminosity is not by itself a suitable distance indicator for quasars.Comment: 3 pages, 1 figure. Accepted for publication in MNRA

Giant Cell Tumor of Bone: Documented Progression over 4 Years from Its Origin at the Metaphysis to the Articular Surface.

The exact location of origin for giant cell tumors of bone (GCTB) remains controversial, as lesions are not routinely imaged early but rather late when the tumor is large and clinically symptomatic. At the time of diagnosis, GCTB are classically described as lucent, eccentric lesions with nonsclerotic margins, located within the epiphysis to a greater extent than the metaphysis. Here we present a case of a biopsy proven GCTB initially incidentally seen on MRI as a small strictly metaphyseal lesion, which over the course of several years expanded across a closed physis to involve the epiphysis and abut the articular surface/subchondral bone plate

PhoSim-NIRCam: Photon-by-photon image simulations of the James Webb Space Telescope's Near-Infrared Camera

Recent instrumentation projects have allocated resources to develop codes for simulating astronomical images. Novel physics-based models are essential for understanding telescope, instrument, and environmental systematics in observations. A deep understanding of these systematics is especially important in the context of weak gravitational lensing, galaxy morphology, and other sensitive measurements. In this work, we present an adaptation of a physics-based ab initio image simulator: The Photon Simulator (PhoSim). We modify PhoSim for use with the Near-Infrared Camera (NIRCam) -- the primary imaging instrument aboard the James Webb Space Telescope (JWST). This photon Monte Carlo code replicates the observational catalog, telescope and camera optics, detector physics, and readout modes/electronics. Importantly, PhoSim-NIRCam simulates both geometric aberration and diffraction across the field of view. Full field- and wavelength-dependent point spread functions are presented. Simulated images of an extragalactic field are presented. Extensive validation is planned during in-orbit commissioning

The Curious Case of PHL 293B : a long-lived transient in a Metal-poor Blue Compact Dwarf Galaxy

We report on small-amplitude optical variability and recent dissipation of the unusually persistent broad emission lines in the blue compact dwarf galaxy PHL 293B. The galaxy's unusual spectral features (P Cygni-like profiles with ~800 km s−1 blueshifted absorption lines) have resulted in conflicting interpretations of the nature of this source in the literature. However, analysis of new Gemini spectroscopy reveals the broad emission has begun to fade after being persistent for over a decade prior. Precise difference imaging light curves constructed with the Sloan Digital Sky Survey and the Dark Energy Survey reveal small-amplitude optical variability of ~0.1 mag in the g band offset by 100 ± 21 pc from the brightest pixel of the host. The light curve is well-described by an active galactic nuclei (AGN)-like damped random walk process. However, we conclude that the origin of the optical variability and spectral features of PHL 293B is due to a long-lived stellar transient, likely a Type IIn supernova or nonterminal outburst, mimicking long-term AGN-like variability. This work highlights the challenges of discriminating between scenarios in such extreme environments, relevant to searches for AGNs in dwarf galaxies. This is the second long-lived transient discovered in a blue compact dwarf, after SDSS1133. Our result implies such long-lived stellar transients may be more common in metal-deficient galaxies. Systematic searches for low-level variability in dwarf galaxies will be possible with the upcoming Legacy Survey of Space and Time at the Vera C. Rubin Observatory

Dwarf AGNs from Variability for the Origins of Seeds (DAVOS): Optical Variability of Broad-line Dwarf AGNs from the Zwicky Transient Facility

We study the optical variability of a sample of candidate low-mass (dwarf ang Seyfert) active galactic nuclei (AGNs) using Zwicky Transient Facility g-band light curves. Our sample is compiled from broad-line AGNs in dwarf galaxies reported in the literature with single-epoch virial black hole (BH) masses in the range $M_{\rm{BH}} \sim 10^{4}$--$10^{8}\ M_{\odot}$. We measure the characteristic ``damping'' timescale of the optical variability $\tau_{\rm{DRW}}$, beyond which the power spectral density flattens, of a final sample of 79 candidate low-mass AGNs with high-quality light curves. Our results provide further confirmation of the $M_{\rm{BH}} - \tau_{\rm{DRW}}$ relation from Burke et al. 2022 within $1\sigma$ agreement, adding 78 new low-mass AGNs to the relation. The agreement suggests that the virial BH mass estimates for these AGNs are generally reasonable. We expect that the optical light curve of an accreting intermediate-mass black hole (IMBH) to vary with a rest-frame damping timescale of $\sim$ tens of hours, which could enable detection and direct mass estimation of accreting IMBHs in wide-field time-domain imaging surveys with sufficient cadence like with the Vera C. Rubin Observatory.Comment: 9 pages plus 6 appendix, 7 figure

The curious case of PHL 293B: a long-lived transient in a metal-poor blue compact dwarf galaxy

Artículo escrito por un elevado número de autores, sólo se referencian el que aparece en primer lugar, los autores pertenecientes a la UAM y el nombre del grupo de colaboración, si lo hubiereWe report on small-amplitude optical variability and recent dissipation of the unusually persistent broad emission lines in the blue compact dwarf galaxy PHL 293B. The galaxy's unusual spectral features (P Cygni-like profiles with ∼800 km s-1 blueshifted absorption lines) have resulted in conflicting interpretations of the nature of this source in the literature. However, analysis of new Gemini spectroscopy reveals the broad emission has begun to fade after being persistent for over a decade prior. Precise difference imaging light curves constructed with the Sloan Digital Sky Survey and the Dark Energy Survey reveal small-amplitude optical variability of ∼0.1 mag in the g band offset by 100 21 pc from the brightest pixel of the host. The light curve is well-described by an active galactic nuclei (AGN)-like damped random walk process. However, we conclude that the origin of the optical variability and spectral features of PHL 293B is due to a long-lived stellar transient, likely a Type IIn supernova or nonterminal outburst, mimicking long-term AGN-like variability. This work highlights the challenges of discriminating between scenarios in such extreme environments, relevant to searches for AGNs in dwarf galaxies. This is the second long-lived transient discovered in a blue compact dwarf, after SDSS1133. Our result implies such long-lived stellar transients may be more common in metal-deficient galaxies. Systematic searches for low-level variability in dwarf galaxies will be possible with the upcoming Legacy Survey of Space and Time at the Vera C. Rubin ObservatoryThe DES data management system is supported by the National Science Foundation under grant Nos. AST-1138766 and AST-1536171. The DES participants from Spanish institutions are partially supported by MINECO under grants AYA2015-71825, ESP2015-66861, FPA2015-68048, SEV2016-0588, SEV-2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007–2013) including ERC grant agreements 240672, 291329, and 30647

Dwarf AGNs from Variability for the Origins of Seeds (DAVOS): Intermediate-mass black hole demographics from optical synoptic surveys

We present a phenomenological forward Monte Carlo model for forecasting the population of active galactic nuclei (AGNs) in dwarf galaxies observable via their optical variability. Our model accounts for expected changes in the spectral energy distribution of AGNs in the intermediate-mass black hole (IMBH) mass range and uses observational constraints on optical variability as a function of black hole (BH) mass to generate mock light curves. Adopting several different models for the BH occupation function, including one for off-nuclear IMBHs, we quantify differences in the predicted local AGN mass and luminosity functions in dwarf galaxies. As a result, we are able to model the variable fraction of AGNs as a function of physical host properties, such as host galaxy stellar mass, in the presence of complex selection effects. We find that our adopted occupation fractions for the "heavy" and "light" initial BH seeding scenarios can be distinguished with variability data at the $2-3 \sigma$ level for galaxy host stellar masses below $\sim 10^8 M_\odot$ with the Vera C. Rubin Observatory. We demonstrate the prevalence of a selection bias whereby recovered IMBH masses fall, on average, above the predicted value from the local host galaxy - BH mass scaling relation with the strength of the bias dependent on the survey sensitivity. The methodology developed in this work can be used more broadly to forecast and correct for selection effects for AGN demographic studies in synoptic surveys. Finally, we show that a targeted $\sim$ hourly cadence program over a few nights with the Rubin Observatory can provide strong constraints on IMBH masses given their expected rapid variability timescales.Comment: 26 pages, 16 figures incl. 5 appendices; re-submitted to MNRAS following referee repor

Engineering enzymes with non-canonical active site functionality

The combination of computational enzyme design and laboratory evolution provides an attractive platform for the creation of protein catalysts with new function. To date, designed mechanisms have relied upon Nature’s alphabet of 20 genetically encoded amino acids, which greatly restricts the range of functionality which can be installed into enzyme active sites. Here, we have exploited engineered components of the cellular translation machinery to create a protein catalyst which operates via a non-canonical catalytic nucleophile. We have subsequently shown that powerful laboratory evolution protocols can be readily adapted to allow optimization of enzymes containing non-canonical active site functionality. Crystal structures obtained along the evolutionary trajectory highlight the origins of improved activity. Thus our approach merges beneficial features of organo- and biocatalysis, by combining the intrinsic reactivities and greater versatility of small molecule catalysts with the rate enhancements, reaction selectivities and evolvability of proteins. Please click Additional Files below to see the full abstract