42 research outputs found

    Key environmental stress biomarker candidates for the optimisation of chemotherapy treatment of leukaemia

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    The impact of fluctuations of environmental parameters such as oxygen and starvation on the evolution of leukaemia is analysed in the current review. These fluctuations may occur within a specific patient (in different organs) or across patients (individual cases of hypoglycaemia and hyperglycaemia). They can be experienced as stress stimuli by the cancerous population, leading to an alteration of cellular growth kinetics, metabolism and further resistance to chemotherapy. Therefore, it is of high importance to elucidate key mechanisms that affect the evolution of leukaemia under stress. Potential stress response mechanisms are discussed in this review. Moreover, appropriate cell biomarker candidates related to the environmental stress response and/or further resistance to chemotherapy are proposed. Quantification of these biomarkers can enable the combination of macroscopic kinetics with microscopic information, which is specific to individual patients and leads to the construction of detailed mathematical models for the optimisation of chemotherapy. Due to their nature, these models will be more accurate and precise (in comparison to available macroscopic/black box models) in the prediction of responses of individual patients to treatment, as they will incorporate microscopic genetic and/or metabolic information which is patient-specific.peer-reviewe

    O ENSINO DE CONCEITOS DA MATEM√ĀTICA UTILIZANDO DADOS EXPERIMENTAIS COM A PANC PERESKIA ACULEATA MIIL DE CAMPO EXPERIMENTAL DO PIP.

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    : Este artigo refere-se ao relato de experi√™ncia did√°tico-pedag√≥gica, vivenciada por docentes e discentes do curso de Agronomia da Universidade Federal do Tocantins- UFT, a√ß√£o do Projeto vinculado ao Programa Institucional de Inova√ß√£o Pedag√≥gica (PIIP). A Matem√°tica foi apontada como a disciplina com maior reprova√ß√£o no curso, fator que estimulou os acad√™micos a formularem, sob a orienta√ß√£o de docentes da disciplina e de outras correlatas, uma proposta metodol√≥gica contemplando conte√ļdos b√°sicos que podem ser considerados entraves (quando n√£o aprendidos durante a educa√ß√£o b√°sica) √† aprendizagem de conte√ļdos mais complexos, tais como Limites, Derivadas e Integrais, que complementam a ementa da referida disciplina. Prosseguiu-se, ent√£o, com sua aplica√ß√£o na modalidade de Oficina, ministrada pelos acad√™micos de per√≠odos mais avan√ßados. Para avalia√ß√£o dessa a√ß√£o, foi aplicado pr√© e p√≥s-teste a dezoito acad√™micos matriculados na disciplina de Matem√°tica. Os resultados apontam que houve avan√ßos na intera√ß√£o entre estudantes de diferentes est√°gios acad√™micos, na familiaridade com aplicativos e ferramentas facilitadoras de aprendizagem e na verifica√ß√£o da import√Ęncia dos temas apresentados em rela√ß√£o √†s disciplinas espec√≠ficas do Curso de Agronomia

    Human toxocariasis: contribution by Brazilian researchers

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    In the present paper the main aspects of the natural history of human infection by Toxocara larvae that occasionally result in the occurrence of visceral and/or ocular larva migrans syndrome were reviewed. The contribution by Brazilian researchers was emphasized, especially the staff of the Tropical Medicine Institute of S√£o Paulo (IMT)

    VIII Encuentro de Docentes e Investigadores en Historia del Dise√Īo, la Arquitectura y la Ciudad

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    Acta de congresoLa conmemoraci√≥n de los cien a√Īos de la Reforma Universitaria de 1918 se present√≥ como una ocasi√≥n propicia para debatir el rol de la historia, la teor√≠a y la cr√≠tica en la formaci√≥n y en la pr√°ctica profesional de dise√Īadores, arquitectos y urbanistas. En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Dise√Īo, la Arquitectura y la Ciudad constituy√≥ un espacio de intercambio y reflexi√≥n cuya realizaci√≥n ha sido posible gracias a la colaboraci√≥n entre Facultades de Arquitectura, Urbanismo y Dise√Īo de la Universidad Nacional y la Facultad de Arquitectura de la Universidad Cat√≥lica de C√≥rdoba, contando adem√°s con la activa participaci√≥n de mayor√≠a de las Facultades, Centros e Institutos de Historia de la Arquitectura del pa√≠s y la regi√≥n. Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Dise√Īo Industrial de todos los niveles de la FAUD-UNC promovi√≥ el debate de ideas a partir de experiencias concretas en instancias tales como mesas tem√°ticas de car√°cter interdisciplinario, que adoptaron la modalidad de presentaci√≥n de ponencias, entre otras actividades. En el √°mbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de C√≥rdoba, se desplegaron numerosas posiciones sobre la ense√Īanza, la investigaci√≥n y la formaci√≥n en historia, teor√≠a y cr√≠tica del dise√Īo, la arquitectura y la ciudad; sum√°ndose el aporte realizado a trav√©s de sus respectivas conferencias de Ana Clarisa Ag√ľero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates. El evento recibi√≥ el apoyo de las autoridades de la FAUD-UNC, en especial de la Secretar√≠a de Investigaci√≥n y de la Biblioteca de nuestra casa, como as√≠ tambi√©n de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento

    Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.

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    BACKGROUND: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. METHODS: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. FINDINGS: The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. INTERPRETATION: Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. FUNDING: WHO

    Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

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    Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30‚Äď79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30‚Äď79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306‚Äď359) million women and 317 (292‚Äď344) million men in 1990 to 626 (584‚Äď668) million women and 652 (604‚Äď698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55‚Äď62) of women and 49% (46‚Äď52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43‚Äď51) of women and 38% (35‚Äď41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20‚Äď27) for women and 18% (16‚Äď21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings

    Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants