4 research outputs found

    Survival after lethal rTcdA challenge in mice.

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    <p>Kaplan-Meier plot of survival following lethal challenge with rTcdA alone, or treatment with CANmAbA4 at either 250 μg or 50 μg dose in comparison to the CDA1 anti-TcdA and polyclonal (pAb anti-TcdA) control. Following lethal challenge, mice (n = 10) were monitored and sacrificed according to approved protocols. Statistical analysis (Log-rank Test) using GraphPad prism 5 indicated that all antibody treated groups had statistically significant higher survival rate compared to control group (rTcdA alone) (P<0.001). There is no significant difference in survival rate among antibody treated groups.</p

    Survival after lethal rTcdB challenge in mice.

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    <p>Kaplan-Meier plot of survival following lethal challenge with rTcdB alone, or treatment with CANmAbB4 or CANmAbB1 at either 250 or 75 μg doses in comparison to the anti-TcdB rabbit polyclonal (pAb anti-TcdB) control. Following lethal challenge mice (n = 10) were monitored and sacrificed according to approved protocols. Statistical analysis (Log-rank Test) using GraphPad prism 5 indicated that all antibody treated groups had statistically significant higher survival rate compared to control group (rTcdA alone) (P<0.001). While CANmAbB4 treated animals (both 250 μg and 75 μg) showed statistically significant higher survival rate in comparison with CANmAbB1 (250 μg) (P<0.01).</p
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