Cardenas-Garcia v. Eighth Jud. Dist. Ct., 140 Nev. Adv. Op. 52 (Aug. 22, 2024)

NRS 432B.555 instructs courts not to release a child to the custody of a parent or guardian who has been convicted of felony child abuse, neglect, or endangerment unless that parent proves by clear and convincing evidence that the child would not be harmed. The issue before the Nevada Supreme Court is how this law applies to parents and guardians who have had their felony convictions withdrawn. The Court held that NRS 432B.555 still applies to parents and guardians who have had their felony convictions withdrawn

Perioperative corneal abrasion: An investigation into preventive practices and educational interventions that limit corneal abrasions in the perioperative setting

Corneal abrasions are the most common ophthalmic injuries that occur in the perioperative period. Corneal abrasions that occur while the patient is under anesthesia are the result of either physical trauma, exposure, or patient related factors. Anesthesiology departments rarely develop continuing education focusing on the reduction of corneal abrasion incidence. Evidenced-based guidelines for corneal abrasion prevention techniques were reviewed while developing an educational program focused on corneal abrasion prevention amongst a group of Certified Registered Nurse Anesthetists (CRNAs). An educational presentation was given to twenty-eight CRNAs. The goal of the presentation is to reduce corneal abrasions in the perioperative setting, educate CRNAs the risk factors associated with increased occurrence of corneal abrasions, and practices reduce corneal abrasions. Pre-and post-tests were performed to evaluate the effectiveness of the educational presentation. After completion of the post-test, the results showed an improvement in the knowledge base related to corneal abrasions

Study of the Systematic Uncertainties associated with the Tracking Detectors

The muon g-2 experiment at Fermilab looks to measure the anomalous magnetic moment of the muon to an unprecedented precision of 0.14 ppm to verify results from the E821 experiment at Brookhaven National Laboratory. In addition to the anomalous magnetic moment of the muon the project also seeks to search for a muon electric dipole moment with a better precision than has previously has been achieved. These measurement along with standard model predictions may result in a discrepancy between the standard model and experimental results which may give some insight to beyond standard model physics. This thesis will present the results for systematics studies from the straw tube trackers in this experiment; mainly the resolution and cross talk in the detectors. It will also present how this will vary with a few of the final measurements for this experiment

Fully-automated in vivo single cell electrophysiology

In this work, we report progress in developing a device that allows fully autonomous sequential patch clamp experimentation. The machine works by integrating a storage magazine of pre-filled pipettes that can be accessed, and swapped, by the headstage at the conclusion of each experiment. In operation, following each neuron measurement, the program enters “swap” state where a set of programmed actuator movements take place. First, the headstage translates towards the pipette storage assembly and deposits its used pipette. The storage assembly rotates to index a fresh pipette, its is grasped, and finally, the headstage returns to its previously designated home position in preparation of subsequent experiments

Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques.

Optogenetic studies in mice have revealed new relationships between well-defined neurons and brain functions. However, there are currently no means to achieve the same cell-type specificity in monkeys, which possess an expanded behavioral repertoire and closer anatomical homology to humans. Here, we present a resource for cell-type-specific channelrhodopsin expression in Rhesus monkeys and apply this technique to modulate dopamine activity and monkey choice behavior. These data show that two viral vectors label dopamine neurons with greater than 95% specificity. Infected neurons were activated by light pulses, indicating functional expression. The addition of optical stimulation to reward outcomes promoted the learning of reward-predicting stimuli at the neuronal and behavioral level. Together, these results demonstrate the feasibility of effective and selective stimulation of dopamine neurons in non-human primates and a resource that could be applied to other cell types in the monkey brain.This work was supported by the Wellcome Trust (Principal Research Fellowship and Programme Grant 095495), European Research Council (ERC Advanced Grant 293549), and NIH Caltech Conte Center (P50MH094258)

Aerodynamic measurements and thermal tests of a strain-gage balance in a cryogenic wind tunnel

An internal strain-gage balance designed and constructed in Europe for use in cryogenic wind tunnels has been tested in the Langley 0.3-Meter Transonic Cryogenic Tunnel. Part of the evaluation was made at equilibrium balance temperatures and it consisted of comparing the data taken at a tunnel stagnation temperature of 300 K with the data taken at 200 K and 110 K while maintaining either the Reynolds number or the stagnation pressure. A sharp-leading-edge delta-wing model was used to provide the aerodynamic loading for these tests. Results obtained with the balance during the force tests were found to be accurate and repeatable both with and without the use of a convection shield on the balance. An additional part of this investigation involved obtaining data on the transient temperature response of the balance during both normal and rapid changes in the tunnel stagnation temperature. The variation of the temperature with time was measured at three locations on the balance near the physical locations of the strain gages. The use of a convection shield significantly increased the time required for the balance to stabilize at a new temperature during the temperature response tests

Eosinophil Response in Guinea Pig Skin to a Low Molecular Weight Eosinophil Chemotactic Factor Extracted from Livers of Mice with Schistosomiasis

A low-molecular weight eosinophil chemotactic factor (ECF-G), isolated and partially purified from livers of mice with schistosomiasis, was injected intradermally into guinea pigs. Biopsies obtained were studied for inflammatory cell accumulation in the injected sites and compared with those in the control sites injected with phosphate buffered saline. Tissue eosinophilia was seen as early as 1hr after injection of ECF-G, but not in the control site. The increase of eosinophilia appeared biphasic with peaks at 6 and 24hr. Mast cells increased in both ECF-G and saline injected sites and the increase was still found at 120hr after injection. Neutrophils also increased in both ECF-G and saline injected sites but disappeared within 48hr.These findings indicate that ECF-G is a tissue and species nonspecific eosinophil chemotactic factor, and injection of ECF-G initiates interaction of eosinophils and mast cells in the skin

Airway dimensions in COPD:relationships with clinical variables

SummaryBackgroundCOPD patients have varying degrees of airways disease and emphysema. CT scanning can differentiate these pathological subtypes. We evaluated airway dimensions and emphysema severity with low dose CT scanning in COPD patients to determine relationships with clinical features of the disease.MethodsFifty six patients with COPD had a low dose thoracic CT scan. Airways were analysed using novel software as either proximal (1st and 2nd generation) or distal (3rd to 6th generation); the extent of emphysema was assessed as the percentage of pixels less than −950 Hounsfield units. CT measures were related to clinical features of COPD.ResultsThicker walls in the proximal airways were associated with clinical features that may represent a bronchitic phenotype (MRC Bronchitis Score; β = 0.20, p = 0.003, Frequent Exacerbations; β = 0.14, p = 0.017, Total St George’s Score; β = 0.50, p = 0.001 and body mass index [BMI]; β = 0.26, p = 0.049); these associations were independent of emphysema. BMI was negatively correlated with the degree of emphysema (β = −0.41, p = 0.001). Airway wall thickness was negatively correlated with CT measured emphysema for both proximal and more distal airways (r = −0.30, p = 0.025 and r = −0.32, p = 0.015).ConclusionsCT measured airway dimensions are associated with several clinical measures of COPD; these are related to a bronchitic phenotype and the effect is independent of emphysema

Beta-Catenin Signaling Plays a Disparate Role in Different Phases of Fracture Repair: Implications for Therapy to Improve Bone Healing

In a study in mice Benjamin Alman and colleagues show that β-catenin functions differently in different stages of fracture repair; moreover, activation of β-catenin by lithium improves fracture healing when used in later phases of repair