Social Relationships and Mortality Risk: A Meta-analytic Review

In a meta-analysis, Julianne Holt-Lunstad and colleagues find that individuals' social relationships have as much influence on mortality risk as other well-established risk factors for mortality, such as smoking

From Self-Soothing to Success: How Behaviors Shape Academic Outcomes.

Childhood coping mechanisms shape the development of positive behaviors, with self-soothing linked to better coping and increased prosocial actions. Students who engage in prosocial behaviors tend to excel academically, yet research rarely connects self-soothing, prosocial behavior, and academic performance. In the present study, we explore these relationships, starting with self-soothing techniques, the frequency of prosocial behaviors, and academic achievement. We hypothesize that students from low-income backgrounds will exhibit maladaptive self-soothing behaviors, leading to fewer prosocial behaviors and lower academic performance. Our second hypothesis is that students with higher GPAs will demonstrate positive self-soothing behaviors and engage in more prosocial behaviors. Our final hypothesis is that students with fewer support systems will cope poorly, exhibit fewer prosocial behaviors, and perform poorly academically, compared to their peers. We surveyed Eastern Kentucky University students to explore these hypotheses. We hope these findings help prepare students to perform better academically to decrease stress and increase positive long-term outcomes

A survey of current practices for genomic sequencing test interpretation and reporting processes in US laboratories

PURPOSE While the diagnostic success of genomic sequencing expands, the complexity of this testing should not be overlooked. Numerous laboratory processes are required to support the identification, interpretation and reporting of clinically significant variants. This study aimed to examine workflow and reporting procedures among US laboratories to highlight shared practices and identify areas in need of standardization. METHODS Surveys and follow-up interviews were conducted with laboratories offering exome and/or genome sequencing, to support a research program or for routine clinical services. The 73-item survey elicited multiple choice and free text responses, later clarified with phone interviews. RESULTS Twenty-one laboratories participated. Practices highly concordant across all groups included: consent documentation, multi-person case review, and enabling patient opt-out of incidental or secondary findings analysis. Noted divergence included use of phenotypic data to inform case analysis and interpretation, and reporting of case-specific quality metrics and methods. Few laboratory policies detailed procedures for data reanalysis, data sharing or patient access to data. CONCLUSION This study provides an overview of practices and policies of experienced exome and genome sequencing laboratories. The results enable broader consideration of which practices are becoming standard approaches, where divergence remains, and areas development of best practice guidelines may be helpful