Sur le Regina Cœli: Paraphrase de l\u27antienne liturgique

A French arrangement for solo voice of the Regina Cœli, one of the Marian antiphons sung during night prayers (Compline). The music was composed by Charles Bordes and the lyrics are based on a poem by l\u27abbé Picard. Included as part of a supplement in the May 1911 issue of Mois Littéraire et Pittoresque, a monthly Catholic magazine published by the Maison de la Bonne Presse, which was run by the Augustine Fathers of the Assumption.https://ecommons.udayton.edu/imri_sheetmusic/1041/thumbnail.jp

Sur le Salve Regina: Paraphrase de l\u27antienne liturgique

A French arrangement for solo voice of the Salve Regina, one of the Marian antiphons sung during night prayers (Compline). The music was composed by Charles Bordes and the lyrics were written by Pierre Lhande. Included as part of a supplement in the May 1911 issue of Mois Littéraire et Pittoresque, a monthly Catholic magazine published by the Maison de la Bonne Presse, which was run by the Augustine Fathers of the Assumption.https://ecommons.udayton.edu/imri_sheetmusic/1042/thumbnail.jp

Sur l\u27alma redemptoris: Paraphrase de l\u27antienne liturgique

A French arrangement for solo voice of the Alma Redemptoris Mater, one of the Marian antiphons sung during night prayers (Compline). The music was composed by Charles Bordes and the lyrics were written by Pierre Lhande. Included as part of a supplement in the May 1911 issue of Mois Littéraire et Pittoresque, a monthly Catholic magazine published by the Maison de la Bonne Presse, which was run by the Augustine Fathers of the Assumption.https://ecommons.udayton.edu/imri_sheetmusic/1040/thumbnail.jp

Three Numerical Puzzles and the Top Quark's Chiral Weak-Moment

Versus the standard model's t --> W b decay helicity amplitudes, three numerical puzzles occur at the 0.1 % level when one considers the amplitudes in the case of an additional (f_M + f_E) coupling of relative strength 53 GeV. The puzzles are theoretical ones which involve the t --> W b decay helicity amplitudes in the two cases, the relative strength of this additional coupling, and the observed masses of these three particles. A deeper analytic realization is obtained for two of them. Equivalent realizations are given for the remaining one. An empirical consequence of these analytic realizations is that it is important to search for effects of a large chiral weak-moment of the top-quark, the effective mass-scale is about 53 GeV. A full theoretical resolution would include relating the origin of such a chiral weak-moment and the mass generation of the top-quark, the W-boson, and probably the b-quark.Comment: 18 pages, 1 postscript table (revised to better explain notation, model #1, add a little material...

Report of the GDR working group on the R-parity violation

This report summarizes the work of the "R-parity violation group" of the French Research Network (GDR) in Supersymmetry, concerning the physics of supersymmetric models without conservation of R-parity at HERA, LEP, Tevatron and LHC and limits on R-parity violating couplings from various processes. The report includes a discussion of the recent searches at the HERA experiment, prospects for new experiments, a review of the existing limits, and also theoretically motivated alternatives to R-parity and a brief discussion on the implications of R-parity violation on the neutrino masses.Comment: 60 pages, LaTeX, 22 figures, 2 table

FTPL and war reparations : the French and German monetary experiences in the Interwar period (In French)

In this paper, we try to investigate the rationale for using the Fiscal Theory of the Price Level (FTPL) as a relevant theoretical framework for analysing French and German monetary experiences in the Interwar period. This approach involves considering the evolution of public debt as the main anchoring factor of the price level through the respect of the intertemporal budget constraint by the public sector. French and german stylized facts, especially during the 1919-1926 period seem at first glance to be in accordance with this relationship. A more precise analysis of the monetary policy implementation suggests, however, that only the weak form (instead of the strong one) of the FTPL could have prevailed. Indeed, the requirement of stable public debt dynamics went hand in hand with the domination of monetary policy by fiscal policy.inflation, public debt, FTPL

A Fundamental Regulatory Mechanism Operating through OmpR and DNA Topology Controls Expression of Salmonella Pathogenicity Islands SPI-1 and SPI-2

DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein–DNA and protein–protein interactions is poorly understood. For example, relaxation of DNA supercoiling strongly induces the well-studied pathogenicity gene ssrA (also called spiR) in Salmonella enterica, but neither the mechanism nor the proteins involved are known. We have found that relaxation of DNA supercoiling induces expression of the Salmonella pathogenicity island (SPI)-2 regulator ssrA as well as the SPI-1 regulator hilC through a mechanism that requires the two-component regulator OmpR-EnvZ. Additionally, the ompR promoter is autoregulated in the same fashion. Conversely, the SPI-1 regulator hilD is induced by DNA relaxation but is repressed by OmpR. Relaxation of DNA supercoiling caused an increase in OmpR binding to DNA and a concomitant decrease in binding by the nucleoid-associated protein FIS. The reciprocal occupancy of DNA by OmpR and FIS was not due to antagonism between these transcription factors, but was instead a more intrinsic response to altered DNA topology. Surprisingly, DNA relaxation had no detectable effect on the binding of the global repressor H-NS. These results reveal the underlying molecular mechanism that primes SPI genes for rapid induction at the onset of host invasion. Additionally, our results reveal novel features of the archetypal two-component regulator OmpR. OmpR binding to relaxed DNA appears to generate a locally supercoiled state, which may assist promoter activation by relocating supercoiling stress-induced destabilization of DNA strands. Much has been made of the mechanisms that have evolved to regulate horizontally-acquired genes such as SPIs, but parallels among the ssrA, hilC, and ompR promoters illustrate that a fundamental form of regulation based on DNA topology coordinates the expression of these genes regardless of their origins

Cerebral small vessel disease genomics and its implications across the lifespan

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials.Peer reviewe

Cerebral small vessel disease genomics and its implications across the lifespan

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials.</p