3 research outputs found
Synthesis of a Novel Quinoline Skeleton Introduced Cationic Polyfluorene Derivative for Multimodal Antimicrobial Application
No full textA new functional polyfluorene derivative
containing quinoline skeleton and quarternary ammonium group (QAG)
modified side chains (PFPQ) was synthesized and characterized. The
multimodal antimicrobial effect toward Gram-negative E. coli was achieved by the dark toxicity resulting
from the quinoline skeleton, QAG, and light toxicity resulting from
reactive oxygen species (ROS) produced by the main backbone of PFPQ
under white light. The mechanism of interaction between PFPQ and bacteria
was also demonstrated. PFPQ bound to E. coli mainly through electrostatic interactions causing nearly 50% bacterial
death in the absence of light irradiation, and the huge capability
of PFPQ to generate ROS under white light opened another bactericidal
mode. The killing efficiency was more than 99% upon relatively mild
irradiation under white light (400–800 nm) with a light dose
of 18 J·cm<sup>–2</sup>. PFPQ with the incorporation of
quinoline into the backbones will provide a new versatile strategy
to achieve the multimodal antimicrobial effect to fight against resistant
bacteria
