3 research outputs found

    From the bush to the brain : preclinical stages of ethnobotanical anti-inflammatory and neuroprotective drug discovery : an Australian example

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    The Australian rainforest is a rich source of medicinal plants that have evolved in the face of dramatic environmental challenges over a million years due to its prolonged geographical isolation from other continents. The rainforest consists of an inherent richness of plant secondary metabolites that are the most intense in the rainforest. The search for more potent and more bioavailable compounds from other plant sources is ongoing, and our short review will outline the pathways from the discovery of bioactive plants to the structural identification of active compounds, testing for potency, and then neuroprotection in a triculture system, and finally, the validation in an appropriate neuro-inflammatory mouse model, using some examples from our current research. We will focus on neuroinflammation as a potential treatment target for neurodegenerative diseases including multiple sclerosis (MS), Parkinson’s (PD), and Alzheimer’s disease (AD) for these plant-derived, anti-inflammatory molecules and highlight cytokine suppressive anti-inflammatory drugs (CSAIDs) as a better alternative to conventional nonsteroidal anti-inflammatory drugs (NSAIDs) to treat neuroinflammatory disorders

    Aboriginal identity, world views, research and the story of the Burra'gorang

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    In recent times there has been a growing recognition that some Aboriginal and Torres Strait Islander peoples and communities have been harmed and even divided by those who question their very right to identify as ‘Indigenous or not’ (Bodkin-Andrews & Carlson 2016 ; New South Wales Aboriginal Education Consultative Group [NSW AECG] 2011 ). Numerous scholars have suggested that such ‘questions’ are an unfortunate extension of the continual epistemological violence (a pressure on ways of knowing) that has sought to eradicate the diverse world views, histories, and knowledges of our peoples since colonisation (Bodkin 2013a ; Moreton-Robinson 2011 ; Nakata 2012 ), and that they result in the emergence of stereotypical accusations of ‘inauthenticity’, ‘wanna-be-Aborigines’, ‘welfare-blacks’, ‘fragmentation’ and ‘cultural absurdity’ (Behrendt 2006 ). It is the purpose of this chapter to highlight the existence of this form of epistemological and identity-based violence and explain how it threatens our communities. In addition, such violence will be challenged by focusing on the strength of diverse world views, knowledges and unique stories that exist within Aboriginal and Torres Strait Islander communities today. We also offer you a traditional D’harawal Law Story as the central case study within this chapter. This Law Story holds valuable insights that may guide individuals and communities towards a stronger and more resilient future

    Sensational pedagogies : learning to be affected by country

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    Student capacities to actively listen, sense and feel are often relegated to lower order skills in an education system increasingly governed by measurable outcomes. While most school-based pedagogies focus their approach on cognition, this paper considers how we might make sense of the affective experiences that often resist the deep thinking, independent learning and explanation so often required of students. The guiding aim is to explore how affective learning can be better understood through an Indigenous Australian concept of Country. We apply the pedagogical work of Elizabeth Ellsworth, along with Lacanian psychoanalytic theory to explore ways in which sensation and affect are already a method of learning, but ones that are substantially under-valued in designed curricula. A series of interviews with senior Aboriginal people are presented to assist in understanding the various ways in which affect can lead to thought. The authors present three case studies to highlight how knowledge can be taught through affective experiences of Country
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