Crash dieting: The effects of eating and drinking on driving performance

Previous research suggests that compared to mobile phone use, eating and drinking while driving is more common and is seen as lower risk by drivers. Nevertheless, snacking at the wheel can affect vehicle control to a similar extent as using a hands-free phone, and is actually a causal factor in more crashes. So far, though, there has not been a controlled empirical study of this problem. In an effort to fill this gap in the literature, we used the Brunel University Driving Simulator to test participants on a typical urban scenario. At designated points on the drive, which coincided with instructions to eat or drink, a critical incident was simulated by programming a pedestrian to walk in front of the car. Whilst the driving performance variables measured were relatively unaffected by eating and drinking, perceived driver workload was significantly higher and there were more crashes in the critical incident when compared to driving normally. Despite some methodological limitations of the study, when taken together with previous research, the evidence suggests that the physical demands of eating and drinking while driving can increase the risk of a crash

Effects of treadmill versus overground soccer match simulations on biomechanical markers of anterior cruciate ligament injury risk in side cutting.

Abstract This study aimed to investigate whether treadmill versus overground soccer match simulations have similar effects on knee joint mechanics during side cutting. Nineteen male recreational soccer players completed a 45-min treadmill and overground match simulation. Heart rate (HR) and rating of perceived exertion (RPE) were recorded every 5 min. Prior to exercise (time 0 min), at "half-time" (time 45 min) and 15 min post-exercise (time 60 min), participants performed five trials of 45° side-cutting manoeuvres. Knee abduction moments and knee extension angles were analysed using two-way repeated measures analysis of variance (α = 0.05). Physiological responses were significantly greater during the overground (HR 160 ± 7 beats ∙ min(-1); RPE 15 ± 2) than the treadmill simulation (HR 142 ± 5 beats ∙ min(-1); RPE 12 ± 2). Knee extension angles significantly increased over time and were more extended at time 60 min compared with time 0 min and time 45 min. No significant differences in knee abduction moments were observed. Although knee abduction moments were not altered over time during both simulations, passive rest during half-time induced changes in knee angles that may have implications for anterior cruciate ligament injury risk

MK-0448, a Specific Kv1.5 Inhibitor: Safety, Pharmacokinetics and Pharmacodynamic Electrophysiology in Experimental Animal Models and in Humans.

BACKGROUND: -We evaluated the viability of I(Kur) as a target for maintenance of sinus rhythm in patients with a history of atrial fibrillation through the testing of MK-0448, a novel I(Kur) inhibitor. METHODS AND RESULTS: -In vitro MK-0448 studies demonstrated strong inhibition of I(Kur) with minimal off-target activity. In vivo MK-0448 studies in normal anesthetized dogs demonstrated significant prolongation of the atrial refractory period compared with vehicle controls without affecting the ventricular refractory period. In studies of a conscious dog heart failure model, sustained AF was terminated with bolus intravenous MK-0448 doses of 0.03 and 0.1 mg/kg. These data led to a two-part first-in-human study: Part I evaluated safety and pharmacokinetics, and Part II was an invasive electrophysiologic (EP) study in healthy subjects. MK-0448 was well-tolerated with mild adverse experiences, most commonly irritation at the injection site. During the EP study, ascending doses of MK-0448 were administered, but no increases in atrial or ventricular refractoriness were detected despite achieving plasma concentrations in excess of 2 μM. Follow-up studies in normal anesthetized dogs designed to assess the influence of autonomic tone demonstrated that prolongation of atrial refractoriness with MK-0448 was markedly attenuated in the presence of vagal nerve simulation, suggesting that the effects of I(Kur) blockade on atrial repolarization may be negated by enhanced parasympathetic neural tone. CONCLUSIONS: -The contribution of I(Kur) to human atrial electrophysiology is less prominent than in preclinical models and therefore is likely to be of limited therapeutic value for the prevention of atrial fibrillation

Effectiveness of moving on: an Australian designed generic self-management program for people with a chronic illness

Background: This paper presents the evaluation of “Moving On”, a generic self-management program for people with a chronic illness developed by Arthritis NSW. The program aims to help participants identify their need for behavior change and acquire the knowledge and skills to implement changes that promote their health and quality of life. Method: A prospective pragmatic randomised controlled trial involving two group programs in community settings: the intervention program (Moving On) and a control program (light physical activity). Participants were recruited by primary health care providers across the north-west region of metropolitan Sydney, Australia between June 2009 and October 2010. Patient outcomes were self-reported via pre- and post-program surveys completed at the time of enrolment and sixteen weeks after program commencement. Primary outcomes were change in self-efficacy (Self-efficacy for Managing Chronic Disease 6-Item Scale), self-management knowledge and behaviour and perceived health status (Self-Rated Health Scale and the Health Distress Scale). Results: A total of 388 patient referrals were received, of whom 250 (64.4%) enrolled in the study. Three patients withdrew prior to allocation. 25 block randomisations were performed by a statistician external to the research team: 123 patients were allocated to the intervention program and 124 were allocated to the control program. 97 (78.9%) of the intervention participants commenced their program. The overall attrition rate of 40.5% included withdrawals from the study and both programs. 24.4% of participants withdrew from the intervention program but not the study and 22.6% withdrew from the control program but not the study. A total of 62 patients completed the intervention program and follow-up evaluation survey and 77 patients completed the control program and follow- up evaluation survey. At 16 weeks follow-up there was no significant difference between intervention and control groups in self-efficacy; however, there was an increase in self-efficacy from baseline to follow-up for the intervention participants (t=−1.948, p=0.028). There were no significant differences in self-rated health or health distress scores between groups at follow-up, with both groups reporting a significant decrease in health distress scores. There was no significant difference between or within groups in self-management knowledge and stage of change of behaviours at follow-up. Intervention group attenders had significantly higher physical activity (t=−4.053, p=0.000) and nutrition scores (t=2.315, p= 0.01) at follow-up; however, these did not remain significant after adjustment for covariates. At follow-up, significantly more participants in the control group (20.8%) indicated that they did not have a self-management plan compared to those in the intervention group (8.8%) (X2=4.671, p=0.031). There were no significant changes in other self-management knowledge areas and behaviours after adjusting for covariates at follow-up. Conclusions: The study produced mixed findings. Differences between groups as allocated were diluted by the high proportion of patients not completing the program. Further monitoring and evaluation are needed of the impact and cost effectiveness of the program. Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN1260900029821

Efficient Optimization of Laminated Composites

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Understanding the potential of groundwater teleconnections to forecast hydrological extremes

Groundwater teleconnections is a growing area of research seeking to detect and understand relationships between wide-scale ocean-atmosphere oscillations and groundwater response. Such relationships can yield important predictive information on groundwater variability and extremes for future years or decades. However, due to the complex non-linear relationships between large-scale climate systems and regional to local-scale rainfall, ET and groundwater; detecting wide-scale evidence of such groundwater teleconnections, and their influence on drought and groundwater flooding, has been difficult. Here, we present the biggest groundwater teleconnection study to date, using an improved wavelet-based methodology to (1) quantify the strength of annual to multi-annual cyclical behaviour in monthly groundwater levels in 60 UK reference boreholes; (2) Analyse rainfall and ET to assess the contribution of teleconnections for these periodicities, and (3) evaluate how indicative these cycles are of groundwater extremes in the UK. Our results are the first to quantify the relative strength of seasonal and extra-seasonal variance in monthly groundwater levels, indicating that �7-year cycles in Chalk (limestone) and sandstone groundwater levels are often comparable to seasonality in defining total groundwater level variability.We demonstrate that the �7 year periodicity in groundwater results from a rainfall-based teleconnection with the North Atlantic Oscillation; documenting a clear alignment with every major recorded instance of groundwater drought (and recent instances of groundwater flooding) in the UK. An understanding that the severity of groundwater drought, and to some extent flooding, is enhanced on a 7-year cycle, produced through a teleconnection, provides significant opportunity for forecasting of future groundwater extremes. This understanding will becoming increasingly critical given the expected increased pressure on groundwater resources as a result of climate change, particularly in the UK and Europe

A conceptual model for climatic teleconnection signal control on groundwater variability in the UK and Europe

The ability to predict future variability of groundwater resources in time and space is of critical importance to drought management. Periodic control on groundwater levels from oscillatory climatic systems (such as the North Atlantic Oscillation) offers a potentially valuable source of longer term forecasting capability. While some studies have found evidence of the influence of such climatic oscillations within groundwater records, there is little information on how periodic signals propagate between a climatic system and a groundwater resource. This paper develops a conceptual model of this relationship for groundwater resources in the UK and Europe, based on a review of current research. The studies reviewed here reveal key spatial and temporal signal modulations between climatic oscillations, precipitation, groundwater recharge and groundwater discharge. Generally positive correlations are found between the NAO (as a dominant influence) and precipitation in northern Europe indicating a strong control on water available for groundwater recharge. These periodic signals in precipitation are transformed by the unsaturated and saturated zones, such that signals are damped and lagged. This modulation has been identified to varying degrees, and is dependent on the shape, storage and transmissivity of an aquifer system. This goes part way towards explaining the differences in periodic signal strength found across many groundwater systems in current research. So that an understanding of these relationships can be used by water managers in building resilience to drought, several research gaps have been identified. Among these are improved quantification of spatial groundwater sensitivity to periodic control, and better identification of the hydrogeological controls on signal lagging and damping. Principally, research needs to move towards developing improved predictive capability for the use of periodic climate oscillations as indicators of longer term groundwater variability

Understanding the potential of climate teleconnections to project future groundwater drought

Predicting the next major drought is of paramount interest to water managers globally. Estimating the onset of groundwater drought is of particular importance, as groundwater resources are often assumed to be more resilient when surface water resources begin to fail. A potential source of long-term forecasting is offered by possible periodic controls on groundwater level via teleconnections with oscillatory ocean–atmosphere systems. However, relationships between large-scale climate systems and regional to local-scale rainfall, evapotranspiration (ET) and groundwater are often complex and non-linear so that the influence of long-term climate cycles on groundwater drought remains poorly understood. Furthermore, it is currently unknown whether the absolute contribution of multi-annual climate variability to total groundwater storage is significant. This study assesses the extent to which multi-annual variability in groundwater can be used to indicate the timing of groundwater droughts in the UK. Continuous wavelet transforms show how repeating teleconnection-driven 7-year and 16–32-year cycles in the majority of groundwater sites from all the UK's major aquifers can systematically control the recurrence of groundwater drought; and we provide evidence that these periodic modes are driven by teleconnections. Wavelet reconstructions demonstrate that multi-annual periodicities of the North Atlantic Oscillation, known to drive North Atlantic meteorology, comprise up to 40 % of the total groundwater storage variability. Furthermore, the majority of UK recorded droughts in recent history coincide with a minimum phase in the 7-year NAO-driven cycles in groundwater level, providing insight into drought occurrences on a multi-annual timescale. Long-range groundwater drought forecasts via climate teleconnections present transformational opportunities to drought prediction and its management across the North Atlantic region

Neural correlates of indicators of sound change in Cantonese: evidence from cortical and subcortical processes

Across time, languages undergo changes in phonetic, syntactic and semantic dimensions. Social, cognitive and cultural factors contribute to sound change, a phenomenon in which the phonetics of a language undergo changes over time. Individuals who misperceive and produce speech in a slightly divergent manner (called innovators) contribute to variability in the society, eventually leading to sound change. However, the cause of variability in these individuals is still unknown. In this study, we examined whether such misperceptions are represented in neural processes of the auditory system. We investigated behavioral, subcortical (via FFR), and cortical (via P300) manifestations of sound change processing in Cantonese, a Chinese language in which several lexical tones are merging. Across the merging categories, we observed a similar gradation of speech perception abilities in both behavior and the brain (subcortical and cortical processes). Further, we also found that behavioral evidence of tone merging correlated with subjects’ encoding at the subcortical and cortical levels. These findings indicate that tone-merger categories, that are indicators of sound change in Cantonese, are represented neurophysiologically with high fidelity. Using our results, we speculate that innovators encode speech in a slightly deviant neurophysiological manner, and thus produce speech divergently that eventually spreads across the community and contributes to sound change

Conversion in Turkish : an overview

This paper presents an overview of possible cases of conversion in Turkish. I argue that apparent cases of conversion between nouns and adjectives are cases of syntactic transposition, and apparent cases of conversion between nouns/adjectives and verbs are end products of phonological changes in the history of the language, which resulted in pairs of lexemes that are formally identical synchronically, but not historically. This does not mean that no cases of morphological conversion can be traced in the language. I will present two cases of secondary word-class conversion from derived, inflected and uninflected words to toponyms which might be taken as instances of morphological conversion or derivation by zero-affixation