Desalineación rotacional del implante tibial en artroplastia total de rodilla: estudio con navegación

Objetivo: Estudiar la rotación del implante tibial y el desajuste rotacional de los implantes femoral y tibial en los 19 casos intervenidos de artroplastia total de rodilla modelo Natural II, con sistema de navegación Navitrack® (Zimmer®). Material y Métodos: Estudio prospectivo en una serie consecutiva de 19 casos de artrosis de rodilla. Se analizaron las medidas realizadas con un sistema de navegación: 1- el ángulo entre la línea que va desde la inserción del Ligamento Cruzado Posterior al tercio medio de la tuberosidad tibial anterior y la línea anteroposterior del implante tibial para determinar la rotación del mismo; 2- el ángulo de la línea femoral epicondílea con el bloque de corte que nos dará la rotación del implante femoral. Resultados: La rotación media del implante tibial ha sido - 0,011º ± 0,533 (r: -0,800 / 1,000). La rotación del implante femoral con relación a la línea epicondílea ha sido -3,174º ± 4,733 (r: -12,300 / 7,700). El ajuste rotacional femorotibial ha sido -2,963º ± 4,649 (r: -11,500/ 6,700). Encontramos una alineación rotacional femorotibial en el 63% de los casos. Conclusiones: El sistema de navegación utilizado permite colocar el implante tibial con una rotación adecuada así como evitar un desajuste rotacional entre los implantes femoral y tibial. Actualmente se consideran de forma combinada las rotaciones de los implantes, lo que tiene gran importancia para evitar los problemas rotulianos así como el desgaste del polietileno.To study the rotational alignment of the tibial implant in 19 patients who underwent total knee arthroplasty by surgical navigation system. Material and Methods: Prospective analysis of 19 consecutive patients with knee osteoarthritis. References obtained by the computerized navigation were: 1- the angle between the line from the insertion of the posterior cruciate ligament to the medial tibial tuberosity and the anteroposterior tibial implant line to study the tibial rotation; 2- the angle between the epicondyle line and the cut piece to study the femoral rotation. Results: The media tibial implant rotation was - 0,011º ± 0,533 (r: -0,800/ 1,000). The femoral implant rotation was -3,174º ± 4,733 (r: -12,300 / 7,700). The mean angle of the rotational mismatch of the components was -2,963º ± 4,649 (r: -11,500/ 6,700). There was a good femorotibial mismatch in 63%. Conclusions: The navigation system helps us to put the tibial implant in a good rotation and so a good femorotibial mismatch. Actually we study the combined rotation of the implants to decrease the patelofemoral problems and the polyethylene damage

Illusions of causality: How they bias our everyday thinking and how they could be reduced

Illusions of causality occur when people develop the belief that there is a causal connection between two events that are actually unrelated. Such illusions have been proposed to underlie pseudoscience and superstitious thinking, sometimes leading to disastrous consequences in relation to critical life areas, such as health, finances, and wellbeing. Like optical illusions, they can occur for anyone under well-known conditions. Scientific thinking is the best possible safeguard against them, but it does not come intuitively and needs to be taught. Teaching how to think scientifically should benefit from better understanding of the illusion of causality. In this article, we review experiments that our group has conducted on the illusion of causality during the last 20 years. We discuss how research on the illusion of causality can contribute to the teaching of scientific thinking and how scientific thinking can reduce illusion

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.

Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of the RNA-binding protein HuR (ELAVL1) occurs during colon tumorigenesis and is abnormally present within the cytoplasm, where it post-transcriptionally regulates genes through its interaction with 3\u27UTR AU-rich elements (AREs). Here, we examine the therapeutic potential of targeting HuR using MS-444, a small molecule HuR inhibitor. Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses in non-transformed intestinal cells had no appreciable effects. Mechanistically, MS-444 disrupted HuR cytoplasmic trafficking and released ARE-mRNAs for localization to P-bodies, but did not affect total HuR expression levels. This resulted in MS-444-mediated inhibition of COX-2 and other ARE-mRNA expression levels. Importantly, MS-444 was well tolerated and inhibited xenograft CRC tumor growth through enhanced apoptosis and decreased angiogenesis upon intraperitoneal administration. In vivo treatment of MS-444 inhibited HuR cytoplasmic localization and decreased COX-2 expression in tumors. These findings provide evidence that therapeutic strategies to target HuR in CRC warrant further investigation in an effort to move this approach to the clinic

Ecomorphological characterization of murines and non-arvicoline cricetids (Rodentia) from south-western Europe since the latest Middle Miocene to the Mio-Pliocene boundary (MN 7/8-MN13)

SUBVENCIÓ: Universidad Complutense de Madrid: BOUC UCM 17-5-2016 (CT27 / 16-CT28 / 16)Rodents are the most speciose group of mammals and display a great ecological diversity. Despite the greater amount of ecomorphological information compiled for extant rodent species, studies usually lack of morphological data on dentition, which has led to difficulty in directly utilizing existing ecomorphological data of extant rodents for paleoecological reconstruction because teeth are the most common or often the only micromammal fossils. Here, we infer the environmental ranges of extinct rodent genera by extracting habitat information from extant relatives and linking it to extinct taxa based on the phenogram of the cluster analysis, in which variables are derived from the principal component analysis on outline shape of the upper first molars. This phenotypic ''bracketing'' approach is particularly useful in the study of the fossil record of small mammals, which is mostly represented by isolated teeth. As a case study, we utilize extinct genera of murines and non-arvicoline cricetids, ranging from the Iberoccitanian latest middle Miocene to the Mio-Pliocene boundary, and compare our results thoroughly with previous paleoecological reconstructions inferred by diferent methods. The resultant phenogram shows a predominance of ubiquitous genera among the Miocene taxa, and the presence of a few forest specialists in the two rodent groups (Murinae and Cricetidae), along with the absence of open environment specialists in either group of rodents. This appears to be related to the absence of enduring grassland biomes in the Iberian Peninsula during the late Miocene. High consistency between our result and previous studies suggests that this phenotypic ''bracketing'' approach is a very useful tool

Efecto del silenciamiento de genes que codifican poligalacturonasas sobre el reblandecimiento del fruto de fresa asociado a la maduración

La degradación de las pectinas de la pared celular mediada por poligalacturonasas juega un papel clave en el reblandecimiento de la fresa. Así, el silenciamiento del gen FaPG1 incrementa la firmeza del fruto maduro y alarga su vida postcosecha. Además de FaPG1, en fresa se ha descrito otro gen que codifica una poligalacturonasa específica de maduración, FaPG2. Con el fin de profundizar en el papel de estos genes, se han obtenido plantas transgénicas con el gen FaPG2 silenciado (líneas BPG), así como plantas con FaPG1 y FaPG2 silenciados (líneas ABPG), obtenidas mediante retransformación de una línea antiFaPG1 (APG29) que mostraba un fuerte silenciamiento del gen y un incremento en la firmeza de fruto. Se obtuvieron 24 líneas BPG y 15 ABPG. Estas plantas, junto con la línea APG29 y controles sin transformar, fueron analizadas durante 3 años consecutivos. El 50% de las líneas BPG mostraron mayor firmeza de fruto rojo que el control sin transformar, aunque el incremento en firmeza fue similar al obtenido en la línea APG29. Todas las líneas dobles transformantes dieron frutos de mayor firmeza que el control, siendo los valores ligeramente superiores a los de la línea APG29 en alguna de ellas. A nivel de expresión, las líneas BPG seleccionadas mostraron un silenciamiento del gen FaPG2 que varió entre el 60-70%, e inesperadamente, un silenciamiento significativo de FaPG1, a pesar de la baja homología entre ambos genes. El silenciamiento de FaPG1 en las líneas ABPG fue superior al 95%; sin embargo, el silenciamiento de FaPG2 fue similar al obtenido en las plantas BPG. Estos resultados confirman el papel clave de las poligalacturonasas en el reblandecimiento de la fresa y sugieren la existencia de una regulación compleja en la expresión de ambos genes. Este trabajo ha sido financiado por el proyecto AGL2011-24814 y Fondos FEDERUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Antes que a Luz Trema: antología poética de David Rosenmann-Taub

info:eu-repo/semantics/publishedVersio

El trabajo de Memoria: Pieza fundadora de mi “Autorretrato” - Entrevista a Daniela Montecinos

info:eu-repo/semantics/publishedVersio

Democracias Incompletas. Actores, demandas e Intersecciones.

Edited by Blanco Fernando and Opazo, Cristiáin. Edited volumen, conference proceedings Actores Demandas e Intersecciones. Santiago de Chile, August 2015. Papers devoted to discuss current cultural, social and political issues in the region (Southern Cone)https://digitalcommons.bucknell.edu/books/1064/thumbnail.jp

Estudios sobre sexualidades en América Latina

Resumen de Estudios sobre sexualidades en América LatinaReview of Estudios sobre sexualidades en América Latin