6 research outputs found
One-Pot Synthesis of Benzo[4,5]imidazo[1,2‑<i>a</i>]quinazoline Derivatives via Facile Transition-Metal-Free Tandem Process
A one-pot
transition metal-free method for synthesizing benzoÂ[4,5]ÂimidazoÂ[1,2-<i>a</i>]Âquinazoline and imidazoÂ[1,2-<i>a</i>]Âquinazoline
derivatives has been developed. The approach is widely applicable
to 2-fluoro-, 2-chloro-, 2-bromo- and 2-nitro-substituted aryl aldehyde
and ketone substrates. The fluorescence properties of target compounds
were studied
Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of <i>N</i>‑Fused Benzo[4,5]imidazo[2,1‑<i>b</i>]thiazole Derivatives via Substituted <i>trans</i>-1,2-Diiodoalkenes, 1<i>H</i>‑Benzo[<i>d</i>]imidazole-2-thiols, and Halobenzenes
Two
transition metal (Cu and Pd)-catalyzed C–S, C–N,
and C–C bond cross-coupling reactions for the preparation of <i>N</i>-fused benzoÂ[4,5]ÂimidazoÂ[2,1-<i>b</i>]Âthiazole
derivatives were developed. A variety of 3-substituted and 2,3-disubstituted
benzoÂ[4,5]ÂimidazoÂ[2,1-<i>b</i>]Âthiazoles were efficiently
and conveniently synthesized from the coupling reaction via <i>trans</i>-1,2-diiodoalkenes, 1<i>H</i>-benzoÂ[<i>d</i>]Âimidazole-2-thiols, and halobenzenes in moderate to excellent
yields
Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of <i>N</i>‑Fused Benzo[4,5]imidazo[2,1‑<i>b</i>]thiazole Derivatives via Substituted <i>trans</i>-1,2-Diiodoalkenes, 1<i>H</i>‑Benzo[<i>d</i>]imidazole-2-thiols, and Halobenzenes
Two
transition metal (Cu and Pd)-catalyzed C–S, C–N,
and C–C bond cross-coupling reactions for the preparation of <i>N</i>-fused benzoÂ[4,5]ÂimidazoÂ[2,1-<i>b</i>]Âthiazole
derivatives were developed. A variety of 3-substituted and 2,3-disubstituted
benzoÂ[4,5]ÂimidazoÂ[2,1-<i>b</i>]Âthiazoles were efficiently
and conveniently synthesized from the coupling reaction via <i>trans</i>-1,2-diiodoalkenes, 1<i>H</i>-benzoÂ[<i>d</i>]Âimidazole-2-thiols, and halobenzenes in moderate to excellent
yields
Transition Metal-Free One-Pot Synthesis of Fused 1,4-Thiazepin-5(4<i>H</i>)‑ones and Theoretical Study of the S–N Type Smiles Rearrangement Process
A series
of 1,4-thiazepin-5Â(4<i>H</i>)-one derivatives
were synthesized via a transition metal-free one-pot Smiles rearrangement
process at
room temperature. Regioselective seven-membered heterocycles were
constructed in good to excellent yields. To gain an in-depth understanding
of the S–N type Smiles rearrangement mechanism, a theoretical
study was also
performed by quantum chemistry calculations
Transition Metal-Free One-Pot Synthesis of Fused 1,4-Thiazepin-5(4<i>H</i>)‑ones and Theoretical Study of the S–N Type Smiles Rearrangement Process
A series
of 1,4-thiazepin-5Â(4<i>H</i>)-one derivatives
were synthesized via a transition metal-free one-pot Smiles rearrangement
process at
room temperature. Regioselective seven-membered heterocycles were
constructed in good to excellent yields. To gain an in-depth understanding
of the S–N type Smiles rearrangement mechanism, a theoretical
study was also
performed by quantum chemistry calculations
AIBN-Promoted Synthesis of Bibenzo[<i>b</i>][1,4]thiazines by the Condensation of 2,2′-Dithiodianiline with Methyl Aryl Ketones
A series
of bibenzoÂ[<i>b</i>]Â[1,4]Âthiazines with various
functional groups has been synthesized by a free-radical condensation
reaction. BibenzoÂ[<i>b</i>]Â[1,4]Âthiazines were obtained
in moderate to good yield (up to 85%) through a one-step reaction
of readily available 2,2′-dithiodianiline and methyl aryl ketones
with AIBN as radical initiator in HOAc. BibenzoÂ[<i>b</i>]Â[1,4]Âthiazines exhibit diversiform solid-state packing