One-Pot Synthesis of Benzo[4,5]imidazo[1,2‑<i>a</i>]quinazoline Derivatives via Facile Transition-Metal-Free Tandem Process

A one-pot transition metal-free method for synthesizing benzo­[4,5]­imidazo­[1,2-<i>a</i>]­quinazoline and imidazo­[1,2-<i>a</i>]­quinazoline derivatives has been developed. The approach is widely applicable to 2-fluoro-, 2-chloro-, 2-bromo- and 2-nitro-substituted aryl aldehyde and ketone substrates. The fluorescence properties of target compounds were studied

Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of <i>N</i>‑Fused Benzo[4,5]imidazo[2,1‑<i>b</i>]thiazole Derivatives via Substituted <i>trans</i>-1,2-Diiodoalkenes, 1<i>H</i>‑Benzo[<i>d</i>]imidazole-2-thiols, and Halobenzenes

Two transition metal (Cu and Pd)-catalyzed C–S, C–N, and C–C bond cross-coupling reactions for the preparation of <i>N</i>-fused benzo­[4,5]­imidazo­[2,1-<i>b</i>]­thiazole derivatives were developed. A variety of 3-substituted and 2,3-disubstituted benzo­[4,5]­imidazo­[2,1-<i>b</i>]­thiazoles were efficiently and conveniently synthesized from the coupling reaction via <i>trans</i>-1,2-diiodoalkenes, 1<i>H</i>-benzo­[<i>d</i>]­imidazole-2-thiols, and halobenzenes in moderate to excellent yields

Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of <i>N</i>‑Fused Benzo[4,5]imidazo[2,1‑<i>b</i>]thiazole Derivatives via Substituted <i>trans</i>-1,2-Diiodoalkenes, 1<i>H</i>‑Benzo[<i>d</i>]imidazole-2-thiols, and Halobenzenes

Two transition metal (Cu and Pd)-catalyzed C–S, C–N, and C–C bond cross-coupling reactions for the preparation of <i>N</i>-fused benzo­[4,5]­imidazo­[2,1-<i>b</i>]­thiazole derivatives were developed. A variety of 3-substituted and 2,3-disubstituted benzo­[4,5]­imidazo­[2,1-<i>b</i>]­thiazoles were efficiently and conveniently synthesized from the coupling reaction via <i>trans</i>-1,2-diiodoalkenes, 1<i>H</i>-benzo­[<i>d</i>]­imidazole-2-thiols, and halobenzenes in moderate to excellent yields

Transition Metal-Free One-Pot Synthesis of Fused 1,4-Thiazepin-5(4<i>H</i>)‑ones and Theoretical Study of the S–N Type Smiles Rearrangement Process

A series of 1,4-thiazepin-5­(4<i>H</i>)-one derivatives were synthesized via a transition metal-free one-pot Smiles rearrangement process at room temperature. Regioselective seven-membered heterocycles were constructed in good to excellent yields. To gain an in-depth understanding of the S–N type Smiles rearrangement mechanism, a theoretical study was also performed by quantum chemistry calculations

Transition Metal-Free One-Pot Synthesis of Fused 1,4-Thiazepin-5(4<i>H</i>)‑ones and Theoretical Study of the S–N Type Smiles Rearrangement Process

A series of 1,4-thiazepin-5­(4<i>H</i>)-one derivatives were synthesized via a transition metal-free one-pot Smiles rearrangement process at room temperature. Regioselective seven-membered heterocycles were constructed in good to excellent yields. To gain an in-depth understanding of the S–N type Smiles rearrangement mechanism, a theoretical study was also performed by quantum chemistry calculations

AIBN-Promoted Synthesis of Bibenzo[<i>b</i>][1,4]thiazines by the Condensation of 2,2′-Dithiodianiline with Methyl Aryl Ketones

A series of bibenzo­[<i>b</i>]­[1,4]­thiazines with various functional groups has been synthesized by a free-radical condensation reaction. Bibenzo­[<i>b</i>]­[1,4]­thiazines were obtained in moderate to good yield (up to 85%) through a one-step reaction of readily available 2,2′-dithiodianiline and methyl aryl ketones with AIBN as radical initiator in HOAc. Bibenzo­[<i>b</i>]­[1,4]­thiazines exhibit diversiform solid-state packing