6 research outputs found

    Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression

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    <div><p>Papillary thyroid cancer (PTC) is one of the endocrine cancers with high clinical and genetic heterogeneity. NOTCH signaling and its downstream NOTCH-Regulated Ankyrin Repeat Protein (NRARP) have been implicated in oncogenesis of many cancers, but the roles in PTCs are less studied. In this study, we show that NRARP is frequently over-expressed in thyroid carcinoma. The over-activation of NRARP is highly and positively correlated with NOTCH genes. Moreover, we find that the expression of NRARP is highly associated with several epithelial mesenchymal transition (EMT) markers and contributes to poor survival outcomes. Therefore, these results indicate that NRARP is an important clinical biomarker in thyroid carcinoma and it promotes EMT induction as well as the progression of PTCs via NOTCH signaling activation.</p></div

    Expression correlation between NRARP and NOTCH signaling.

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    <p>A) Enriched pathways that are positively correlated with NRARP. B) Scatter plot of NRARP expression and NOTCH1 expression in TCGA THCA dataset. Each point stands for one tumor patient, of which values in X-axis and Y-axis represent NOTCH1 and NRARP expression, respectively. C) Scatter plots of NRARP and NOTCH3 genes. D) Scatter plots of NRARP and NOTCH4. E) Protein interaction between NRARP and NOTCH genes.</p

    Over-expression of NRARP in thyroid tumors.

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    <p>A) Up-regulated pathways in TCGA THCA dataset. B) Boxplot of NRARP expression profiles in TCGA THCA dataset. C) Boxplot of NRARP expression profiles in public dataset GSE64912. D) Genomic alteration frequency of NRARP in TCGA THCA dataset. Each cell stands for the tumor patient.</p

    Proposed model regulatory model of NRARP in thyroid cancer patients.

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    <p>NRARP and NOTCH related genes are up-regulated in tumor patients and contribute to tumor progression. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0167782#sec013" target="_blank">discussion</a> for details.</p
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