Potential of Constraining Propagation Parameters of Galactic Cosmic Rays with the High Energy cosmic-Radiation Detection facility onboard China's Space Station

Precise measurements of the spectra of secondary and primary cosmic rays are crucial for understanding the origin and propagation of those energetic particles. The High Energy cosmic-Radiation Detection (HERD) facility onboard China`s Space Station, which is expected to operate in 2027, will push the direct measurements of cosmic ray fluxes precisely up to PeV energies. In this work, we investigate the potential of HERD on studying the propagation of cosmic rays using the measurements of boron, carbon, and oxygen spectra. We find that, compared with the current results, the new HERD measurements can improve the accuracy of the propagation parameters by 8\% to 40\%. The constraints on the injection spectra at high energies will also be improved.Comment: 10 pages, 4 figure

THE DEVELOPMENT OF A REAL-TIME FEEDBACK SYSTEM IN WEIGHTLIFTING

The purpose of this study was to develop a real-time feedback system (RTFS), which can provide weightlifters some useful information, such as the heights of the bar, video clip and so on, immediately after finishing their attempts under training conditions. A Kinect was used to capture the depth data and RGB video, the methods of the pattern recognition and algorithm were established, and the software was developed to identify the barbell and calculate the 3-D data of barbell COM (Centre of Mass). An experiment was carried out to compare the data from RTFS and that from 3D analysis based on video to check the reliability of RTFS. The results showed that the data of barbell COM obtained by RTFS can describe the movement of barbell sufficiently. This new system can help weightlifters to diagnose their skills and improve their training effectively

Limited Genetic Connectivity Among Sargassum horneri (Phaeophyceae) Populations in the Chinese Marginal Seas Despite Their high Dispersal Capacity

Sargassum horneri is a habitat-forming species in the Northwest Pacific and an important contributor to seaweed rafts. In this study, 131 benthic samples and 156 floating samples were collected in the Yellow Sea and East China Sea (ECS) to test the effects of seaweed rafts on population structure and connectivity. Our results revealed high levels of genetic diversity in both benthic and floating samples based on concatenated mitochondrial markers (rpl5-rps3, rnl-atp9, and cob-cox2). Phylogenetic analyses consistently supported the existence of two lineages (lineages I and II), with divergence dating to c. 0.692 Mya (95% HPD: 0.255-1.841 Mya), indicating that long-term isolation may have occurred during the mid-Pleistocene (0.126-0.781 Mya). Extended Bayesian skyline plots demonstrated a constant population size over time in lineage I and slight demographic expansion in lineage II. Both lineages were found in each marginal sea (including both benthic and floating samples), but PCoA, F-ST, and AMOVA analyses consistently revealed deep genetic variation between regions. Highly structured phylogeographic pattern supports limited genetic connectivity between regions. IMA analyses demonstrated that asymmetric gene flow between benthic populations in the North Yellow Sea (NYS) and ECS was extremely low (ECS -> NYS, 2Nm = 0.6), implying that high dispersal capacity cannot be assumed to lead to widespread population connectivity, even without dispersal barriers. In addition, there were only a few shared haplotypes between benthic and floating samples, suggesting the existence of hidden donors for the floating masses in the Chinese marginal seas

Efficacy and adverse effects of transdermal fentanyl and sustained-release oral morphine in treating moderate-severe cancer pain in Chinese population: a systematic review and meta-analysis

<p>Abstract</p> <p>Background</p> <p>Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and performed a systematic review.</p> <p>Methods</p> <p>Updated cohort studies on transdermal fentanyl and oral morphine in the treatment of cancer pain were searched in electronic databases including CBMdisc, CNKI, VIP, Medline, EMBASE and Cochrane Library. Primary end points assessed by meta-analysis were remission rate of pain and incidence of adverse effects. Quality of life was assessed by systematic review, which was the second end point.</p> <p>Results</p> <p>32 cohort studies, which included 2651 patients, were included in present study. The remission rate in transdermal fentanyl group and sustained-release oral morphine group were 86.60% and 88.31% respectively, there was no significant difference [RR = 1.13, 95% CI (0.92, 1.38), P = 0.23]. Compared with oral morphine group, there were less adverse effects in terms of constipation [RR = 0.35, 95% CI (0.27, 0.45), P < 0.00001], nausea/vomiting [RR = 0.57, 95% CI (0.49, 0.67), P < 0.00001], and vertigo/somnolence [RR = 0.59, 95% CI (0.51, 0.68), P < 0.00001] in transdermal fentanyl group. Six of selected trials supported either transdermal fentanyl or sustained-release oral morphine improved QOL of cancer patients and one of them showed more patients got better QOL after sustained-release oral morphine transferred to transdermal fentanyl.</p> <p>Conclusions</p> <p>Our study showed again that both transdermal fentanyl and oral morphine had the same efficacy in the treatment of moderate-severe cancer pain in Chinese population, but the former might have less adverse effects and better quality of life.</p

On the Detectability of Galactic Dark Matter Annihilation into Monochromatic Gamma-rays

Monochromatic gamma-rays are thought to be the smoking gun signal for identifying the dark matter annihilation. However, the flux of monochromatic gamma-rays is usually suppressed by the virtual quantum effects since dark matter should be neutral and does not couple with gamma-rays directly. In the work we study the detection strategy of the monochromatic gamma-rays in a future space-based detector. The monochromatic gamma-ray flux is calculated by assuming supersymmetric neutralino as a typical dark matter candidate. We discuss both the detection focusing on the Galactic center and in a scan mode which detects gamma-rays from the whole Galactic halo are compared. The detector performance for the purpose of monochromatic gamma-rays detection, with different energy and angular resolution, field of view, background rejection efficiencies, is carefully studied with both analytical and fast Monte-Carlo method

B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy

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