2,216 research outputs found
Antigen staining for detection of MUC13 and MCU16 in carcinoma tissue
MUC13 and MUC16 are mucosal epithelial expressed proteins associated with various carcinomas. Overexpression of these biomarkers appear to play a role in tumor growth; this discovery has paved a road for multiple studies discussing the potential of targeting mucin proteins and optimize immunotherapy approaches against carcinomas. Our study serves to investigate the level of expression of MUC13 and MUC16 in cancerous and normal tissue and to discuss the implications our findings may have for the utilization of these biomarkers for cancer therapy
Antigen staining for detection of MUC13 and MUC16 expression in carcinoma tissue
MUC13 and MUC16 are epithelial expressed proteins implicated in various carcinomas. Overexpression of these biomarkers appear to play a role in tumor growth; this discovery has paved a road for multiple studies discussing the potential of targeting mucin proteins and optimize immunotherapy approaches against carcinomas. Our study serves to investigate the level of expression of MUC13 and MUC16 in cancerous and normal tissue and to discuss the implications our findings may have for the utilization of these biomarkers for cancer therapy
Job-shop Scheduling Over a Heterogeneous Platform
Real-time scheduling involves determining the allocation of platform resources in such a way tasks can meet their temporal restrictions.
This work focuses on job-shop tasks model in which a task have a finite number of nonpreemptive different instances (jobs) that share a unique hard deadline and their time requirements are known until task arrival.
Non-preemptive scheduling is considered because this characteristic is widely used in industry. Besides job-shop scheduling has direct impacts on the production efficiency and costs of manufacturing systems. So that the development of analysis for tasks with these characteristics is necessary.
The aim of this work is to propose an online scheduling test able to guarantee the execution of a new arriving task, which is generated by human interaction with an embedded system, otherwise to discart it. An extension of the schedulability test proposed by Baruah in 2006 for non-preemptive periodic tasks over an identical platform is presented in this paper. Such extension is applied to non-preemptive tasks that have hard deadlines over a heterogeneous platform. To do that, some virtual changes over both the task set and the platform are effectuated
Detailed Modeling and Reliability Analysis of Fault-Tolerant Processor Arrays
Recent advances in VLSI/WSI technology have led to the design of processor arrays with a large number of processing elements confined in small areas. The use of redundancy to increase fault-tolerance has the effect of reducing the ratio of area dedicated to processing elements over the area occupied by other resources in the array. The assumption of fault-free hardware support (switches, buses, interconnection links, etc.,), leads at best to conservative reliability estimates. However, detailed modeling entails not only an explosive growth in the model state space but also a difficult model construction process. To address the latter problem, a systematic method to construct Markov models for the reliability evaluation of processor arrays is proposed. This method is based on the premise that the fault behavior of a processor array can be modeled by a Stochastic Petri Net (SPN). However, in order to obtain a more compact representation, a set of attributes is associated with each transition in the Petri net model. This representation is referred to as a Modified Stochastic Petri Net (MSPN) model. A MSPN allows the construction of the corresponding Markov model as the reachability graph is being generated. The Markov model generated can include the effect of failures of several different components of the array as well as the effect of a peculiar distribution of faults when the reconfiguration occurs. Specific reconfiguration schemes such as Successive Row Elimination (SRE), Alternate Row-Column Elimination (ARCE) and Direct Reconfiguration (DR), are analyze
Magnetic microscopy of topologically protected homochiral domain walls in an ultrathin perpendicularly magnetized Co film
Next-generation concepts for solid-state memory devices are based on
current-driven domain wall propagation, where the wall velocity governs the
device performance. It has been shown that the domain wall velocity and the
direction of travel is controlled by the nature of the wall and its chirality.
This chirality is attributed to effects emerging from the lack of inversion
symmetry at the interface between a ferromagnet and a heavy metal, leading to
an interfacial Dzyaloshinskii-Moriya interaction that can control the shape and
chirality of the magnetic domain wall. Here we present direct imaging of domain
walls in Pt/Co/AlO films using Lorentz transmission electron microscopy,
demonstrating the presence of homochiral, and thus topologically protected,
N\'{e}el walls. Such domain walls are good candidates for dense data storage,
bringing the bit size down close to the limit of the domain wall width
Electrical Properties and Electromagnetic Interference Shielding Effectiveness of Interlayered Systems Composed by Carbon Nanotube Filled Carbon Nanofiber Mats and Polymer Composites
The demand for multifunctional requirements in aerospace, military, automobile, sports, and energy applications has encouraged the investigation of new composite materials. This study focuses on the development of multiwall carbon nanotube (MWCNT) filled polypropylene composites and carbon nanofiber composite mats. The developed systems were then used to prepare interlayered composites that exhibited improved electrical conductivity and electromagnetic interference (EMI) shielding efficiency. MWCNT-carbon nanofiber composite mats were developed by centrifugally spinning mixtures of MWCNT suspended in aqueous poly(vinyl alcohol) solutions. The developed nanofibers were then dehydrated under sulfuric acid vapors and then heat treated. Interlayered samples were fabricated using a nanoreinforced polypropylene composite as a matrix and then filled with carbon fiber composite mats. The in-plane and through-plane electrical conductivity of an eight-layered flexible carbon composite (0.65 mm thick) were shown to be 6.1 and 3.0 × 10−2 S·cm−1, respectively. The EMI shielding effectiveness at 900 MHz increased from 17 dB for the one-layered composite to 52 dB for the eight-layered composite. It was found that the reflection of the electromagnetic waves was the dominating mechanism for EMI shielding in the developed materials. This study opens up new opportunities for the fabrication of novel lightweight materials that are to be used in communication systems
An outdoor test facility for the Cherenkov Telescope Array mirrors
The Cherenkov Telescopes Array (CTA) is planned to be an Observatory for very high energy γ-ray astronomy and will consist of several tens of telescopes which account for a reflective surface of more than 10000 m2 . The mirrors of these telescopes will be formed by a set of facets. Different technological solutions are under test inside the CTA Consortium. Most of them involve composite structures whose behavior under real observing conditions is not yet fully tested. An outdoor test facility has been built in one of the candidate sites for CTA, in Argentina (San Antonio de los Cobres [SAC], 3600m a.s.l) in order to monitor the optical and mechanical properties of these facets exposed to the local atmospheric conditions for a given period of time. In this work we present the preliminary results of the first Middle Size Telescope (MST) mirror-monitoring campaign, started in 2013.Fil: Medina, Maria Clementina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Garcia, Beatriz Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: Maya, J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: Mancilla, A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: Larrarte, Juan Jose. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Rasztocky, Emiliano. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Benitez, Martin Ezequiel. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Dipold, J.. Instituto de Física de Sao Carlos; BrasilFil: Platino, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: CTA Consortium. No especifíca;33rd International Cosmic Ray Conference (ICRC 2013): The Astroparticle Physics ConferenceRío de JaneiroBrasilCherenkov Telescope Array Consortiu
Pressure-Driven Metallization in Hafnium Diselenide
The quest for new transition metal dichalcogenides (TMDs) with outstanding electronic properties operating at ambient conditions draws us to investigate the 1T-HfSe2 polytype under hydrostatic pressure. Diamond anvil cell (DAC) devices coupled to in- situ synchrotron X-ray, Raman and optical (VIS-NIR) absorption experiments along with density functional theory (DFT) based calculations prove that: (i) bulk 1T-HfSe2 exhibits strong structural and vibrational anisotropies, being the interlayer direction especially sensitive to pressure changes, (ii) the indirect gap of 1T-HfSe2 trend to vanish by a -0.1 eV/GPa pressure rate, slightly faster than MoS2 or WS2, (iii) the onset of the metallic behavior appears at Pmet ~10 GPa, which is to date the lowest pressure among common TMDs, and finally (iv) the electronic transition is explained by the bulk modulus B0-Pmet correlation, along with the pressure coefficient of the band gap, in terms of the electronic overlap between chalcogenide p-type and metal d-type orbitals
De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19
Erythroid leukemia (ERL or AML-M6) is an uncommon subtype of acute myeloid leukemia, the clinical, morphological, and genetic behavior of which needs further characterization. We analyzed a homogeneous group of 23 de novo AML-M6 patients whose bone marrow cells showed complex karyotypes. We also analyzed eight leukemia cell lines with erythroid phenotype, performing detailed molecular cytogenetic analyses, including spectral karyotyping (SKY) in all samples. The main features are: (1) A majority of patients (56%) had hypodiploidy. Loss of genetic material was the most common genetic change, especially monosomies of chromosome 7 or 18, and deletions of chromosome arm 5q. Taken together, 87% of the cases displayed aberrations involving chromosome 5 or 8. (2) We describe a novel, cryptic, and recurrent translocation, t(11;19)(p11.2;q13.1). Another translocation, t(12;21)(p11.2;q11.2), was found to be recurrent in a patient with ERL and in the K562 cell line. (3) MLL gene rearrangements were detected in 20% of cases (three translocations and three amplifications) and, overall, we defined 52 rearrangements (excluding deletions) with a mean of 2.3 translocations per patient. (4) Of the structural aberrations, 21% involved chromosomes 11 and 19. Most of the rearrangements were unbalanced; only 13 reciprocal translocations were observed. The general picture of chromosomal aberrations in cell lines did not reflect what occurred in patient samples. However, both primary samples and cell lines shared three common breakpoints at 19q13.1, 20q11.2, and 21q11.2. This is the first molecular cytogenetic description of the karyotype abnormalities present in patients with ERL. It should assist in the identification of genes involved in erythroleukemogenesis
On the Location of the Gamma-ray Emission in the 2008 Outburst in the BL Lacertae Object AO 0235+164 through Observations across the Electromagnetic Spectrum
We present observations of a major outburst at centimeter, millimeter,
optical, X-ray, and gamma-ray wavelengths of the BL Lacertae object AO
0235+164. We analyze the timing of multi-waveband variations in the flux and
linear polarization, as well as changes in Very Long Baseline Array (VLBA)
images at 7mm with 0.15 milliarcsecond resolution. The association of the
events at different wavebands is confirmed at high statistical significance by
probability arguments and Monte-Carlo simulations. A series of sharp peaks in
optical linear polarization, as well as a pronounced maximum in the 7 mm
polarization of a superluminal jet knot, indicate rapid fluctuations in the
degree of ordering of the magnetic field. These results lead us to conclude
that the outburst occurred in the jet both in the quasi-stationary "core" and
in the superluminal knot, both parsecs downstream of the supermassive black
hole. We interpret the outburst as a consequence of the propagation of a
disturbance, elongated along the line of sight by light-travel time delays,
that passes through a standing recollimation shock in the core and propagates
down the jet to create the superluminal knot. The multi-wavelength light curves
vary together on long time-scales (months/years), but the correspondence is
poorer on shorter time-scales. This, as well as the variability of the
polarization and the dual location of the outburst, agrees with the
expectations of a multi-zone emission model in which turbulence plays a major
role in modulating the synchrotron and inverse Compton fluxes.Comment: Accepted for Publication in the Astrophysical Journal Letters. 7
pages (including 5 figures). Minor corrections with regard to previous
version, as proposed by the refere
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