Comment on ``New ansatz for metric operator calculation in pseudo-Hermitian field theory''

In a recent Brief Report by Shalaby a new first-order perturbative calculation of the metric operator for an $i\phi^3$ scalar field theory is given. It is claimed that the result is an improvement on a previous calculation by Bender, Brody and Jones because it is local. Unfortunately Shalaby's calculation is not valid because of sign errors.Comment: 2 pages, no figures. This comment replaces the previous comment on the Brief Report by Shalaby. In the previous comment we pointed out that Shalaby's calculation failed in all but 2 space-time dimensions. We have subsequently found additional errors which mean that the calculation is not valid even in that cas

Constructing the Tree-Level Yang-Mills S-Matrix Using Complex Factorization

A remarkable connection between BCFW recursion relations and constraints on the S-matrix was made by Benincasa and Cachazo in 0705.4305, who noted that mutual consistency of different BCFW constructions of four-particle amplitudes generates non-trivial (but familiar) constraints on three-particle coupling constants --- these include gauge invariance, the equivalence principle, and the lack of non-trivial couplings for spins >2. These constraints can also be derived with weaker assumptions, by demanding the existence of four-point amplitudes that factorize properly in all unitarity limits with complex momenta. From this starting point, we show that the BCFW prescription can be interpreted as an algorithm for fully constructing a tree-level S-matrix, and that complex factorization of general BCFW amplitudes follows from the factorization of four-particle amplitudes. The allowed set of BCFW deformations is identified, formulated entirely as a statement on the three-particle sector, and using only complex factorization as a guide. Consequently, our analysis based on the physical consistency of the S-matrix is entirely independent of field theory. We analyze the case of pure Yang-Mills, and outline a proof for gravity. For Yang-Mills, we also show that the well-known scaling behavior of BCFW-deformed amplitudes at large z is a simple consequence of factorization. For gravity, factorization in certain channels requires asymptotic behavior ~1/z^2.Comment: 35 pages, 6 figure

On Tree Amplitudes in Gauge Theory and Gravity

The BCFW recursion relations provide a powerful way to compute tree amplitudes in gauge theories and gravity, but only hold if some amplitudes vanish when two of the momenta are taken to infinity in a particular complex direction. This is a very surprising property, since individual Feynman diagrams all diverge at infinite momentum. In this paper we give a simple physical understanding of amplitudes in this limit, which corresponds to a hard particle with (complex) light-like momentum moving in a soft background, and can be conveniently studied using the background field method exploiting background light-cone gauge. An important role is played by enhanced spin symmetries at infinite momentum--a single copy of a "Lorentz" group for gauge theory and two copies for gravity--which together with Ward identities give a systematic expansion for amplitudes at large momentum. We use this to study tree amplitudes in a wide variety of theories, and in particular demonstrate that certain pure gauge and gravity amplitudes do vanish at infinity. Thus the BCFW recursion relations can be used to compute completely general gluon and graviton tree amplitudes in any number of dimensions. We briefly comment on the implications of these results for computing massive 4D amplitudes by KK reduction, as well understanding the unexpected cancelations that have recently been found in loop-level gravity amplitudes.Comment: 22 pages, 3 figure

Exploring the S-Matrix of Massless Particles

We use the recently proposed generalised on-shell representation for scattering amplitudes and a consistency test to explore the space of tree-level consistent couplings in four-dimensional Minkowski spacetime. The extension of the constructible notion implied by the generalised on-shell representation, i.e. the possibility to reconstruct at tree level all the scattering amplitudes from the three-particle ones, together with the imposition of the consistency conditions at four-particle level, allow to rediscover all the known theories and their algebra structure, if any. Interestingly, this analysis seems to leave room for high-spin couplings, provided that at least the requirement of locality is weakened. We do not claim to have found tree-level consistent high-spin theories, but rather that our methods show signatures of them and very likely, with a suitable modification, they can be a good framework to perform a systematic search.Comment: 44 pages, 1 figur

Note on graviton MHV amplitudes

Two new formulas which express n-graviton MHV tree amplitudes in terms of sums of squares of n-gluon amplitudes are discussed. The first formula is derived from recursion relations. The second formula, simpler because it involves fewer permutations, is obtained from the variant of the Berends, Giele, Kuijf formula given in Arxiv:0707.1035.Comment: 10 page

Precision medicine in distinct heart failure phenotypes: Focus on clinical epigenetics

Heart failure (HF) management is challenging due to high clinical heterogeneity of this disease which makes patients responding differently to evidence-based standard therapy established by the current reductionist approach. Better understanding of the genetic and epigenetic interactions may clarify molecular signatures underlying maladaptive responses in HF, including metabolic shift, myocardial injury, fibrosis, and mitochondrial dysfunction. DNA methylation, histone modifications and micro-RNA (miRNAs) may be major epigenetic players in the pathogenesis of HF. DNA hypermethylation of the kruppel-like factor 15 (KLF1.5) gene plays a key role in switching the failing heart from oxidative to glycolytic metabolism. Moreover, hypomethylation at H3K9 promoter level of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes also leads to reactivation of fetal genes in man. The role of miRNAs has been investigated in HF patients undergoing heart transplantation, for whom miR-10a, miR-155, miR-31, and miR-92 may be putative useful prognostic biomarkers. Recently, higher RNA methylation levels have been observed in ischemic human hearts, opening the era of "epitranscriptome" in the pathogenesis of HF. Currently, hydralazine, statins, apabetalone, and omega-3 polyunsatured fatty acids (PUFA) are being tested in clinical trials to provide epigenetic-driven therapeutic interventions. Moreover, network-oriented analysis could advance current medical practice by focusing on protein-protein interactions (PPIs) perturbing the "cardiac" interactome. In this review, we provide an epigenetic map of maladaptive responses in HF patients. Furthermore, we propose the "EPi-transgeneratlonal network mOdeling for STratificatiOn of heaRt Morbidity" (EPIKO-STORM), a clinical research strategy offering novel opportunities to stratify the natural history of HF

Worldline approach to vector and antisymmetric tensor fields

The N=2 spinning particle action describes the propagation of antisymmetric tensor fields, including vector fields as a special case. In this paper we study the path integral quantization on a one-dimensional torus of the N=2 spinning particle coupled to spacetime gravity. The action has a local N=2 worldline supersymmetry with a gauged U(1) symmetry that includes a Chern-Simons coupling. Its quantization on the torus produces the one-loop effective action for a single antisymmetric tensor. We use this worldline representation to calculate the first few Seeley-DeWitt coefficients for antisymmetric tensor fields of arbitrary rank in arbitrary dimensions. As side results we obtain the correct trace anomaly of a spin 1 particle in four dimensions as well as exact duality relations between differential form gauge fields. This approach yields a drastic simplification over standard heat-kernel methods. It contains on top of the usual proper time a new modular parameter implementing the reduction to a single tensor field. Worldline methods are generically simpler and more efficient in perturbative computations then standard QFT Feynman rules. This is particularly evident when the coupling to gravity is considered.Comment: 30 pages, 5 figures, references adde

Effective action for Einstein-Maxwell theory at order RF**4

We use a recently derived integral representation of the one-loop effective action in Einstein-Maxwell theory for an explicit calculation of the part of the effective action containing the information on the low energy limit of the five-point amplitudes involving one graviton, four photons and either a scalar or spinor loop. All available identities are used to get the result into a relatively compact form.Comment: 13 pages, no figure

Tests of quantum gravity-induced non-locality: Hamiltonian formulation of a non-local harmonic oscillator

Motivated by the development of on-going optomechanical experiments aimed at constraining non-local effects inspired by some quantum gravity scenarios, the Hamiltonian formulation of a non-local harmonic oscillator, and its coupling to a cavity field mode(s), is investigated. In particular, we consider the previously studied model of non-local oscillators obtained as the nonrelativistic limit of a class of non-local Klein-Gordon operators, f, with f an analytical function. The results of previous works, in which the interaction was not included, are recovered and extended by way of standard perturbation theory. At the same time, the perturbed energy spectrum becomes available in this formulation, and we obtain the Langevin's equations characterizing the interacting system