1 research outputs found
Palladium-Catalyzed Carbamate-Directed Regioselective Halogenation: A Route to Halogenated Anilines
This study describes an efficient
method for ortho-selective halogenation
of <i>N</i>-arylcarbamates under mild conditions for the
first time. Although being weakly coordinating, <i>N</i>-arylcarbamates act very well as a removable directing group for
activation of C–H bonds. The developed procedure results in
extremely valuable halogenated <i>N</i>-arylcarbmates that
can further be hydrolyzed to halogenated anilines. The obtained reaction
conditions showed broad scope and wide functional group tolerance.
All the products were formed in good yields with extremely high selectivity