2,078 research outputs found
An introductory course on human computer interaction
An introductory course on Human Computer Interaction offered as an elective to the Engineering degree on Electronics and Telecommunications at the University of Aveiro is presented. Its contents, teaching methods and bibliography are briefly described.Apresenta-se resumidamente o programa, métodos de ensino e bibliografia da disciplina de Interfaces Humano Computador que tem sido oferecida desde 1993/94 como opção da Licenciatura em Electrónica e Telecomunicações da Universidade de Aveiro
Ray Casting: uma implementação com vista à realização de estudos de qualidade
An application to visualize voxel based volumes using a ray-caster is presented. This application is meant to allow studing the quality of obtained visualizations and thus the values of a set of parameters relevant to the final quality may be selected.Neste artigo apresenta-se uma aplicação desenvolvida para possibilitar a visualização de volumes definidos por voxeis, utilizando o método de Ray Casting. Esta aplicação foi desenvolvida com o objectivo de estudar a qualidade das visualizações, e assim, permite variar diversos parâmetros associados ao método implementado, para posterior análise dos resultados
Quantitative evaluation and comparison of lung contour extraction methods
Pulmonary contours in chest CT images are closed curves that may, in some cases, exhibit multiple concave and convex irregularities. In this paper we assess the quality of pulmonary contours obtained by several fully automated methods. A comparison among these contours and corresponding manually drawn reference contours was performed and several figures of merit were assigned to each one of the automated contours extraction algorithms. Likeness between a computed contour and reference contour was measured through the Pratt figure of merit, similarity index, mean error and fraction of errors greater than 5pixels. For each of these figures we present an exploratory statistical analysis and discuss its sensibility to the longitudinal location of the CT slice
Experimental Methodology for the Evaluation of the 3D Visualization of Quantitative Information: a Case Study Concerning SEEG Information
The visual analysis of Stereoeletroencephalographic (SEEG) signals in their anatomical context is aimed at understanding the spatio-temporal dynamics of epileptic processes. The magnitude of these signals may be encoded by graphical glyphs, having a direct impact on the perception of the values. This problem has motivated an evaluation of the quantitative visualization of these signals, specifically with regard to the influence of the coding scheme of the glyphs on the understanding and analysis of the signals. This work describes an experiment conducted with human observers in order to evaluate three different coding schemes used to visualize the magnitude of SEEG signals in their 3D anatomical context. Before the experiment we had no clue to which of these schemes would provide better performance to the human observers, while the literature offered theories supporting different answers. Through our experiment we intended to find out if any of these coding schemes allows better performance in two aspects: accuracy and speed. A protocol has been developed to measure these aspects. The results presented in this work were obtained from 40 human observers. Comparison between the three coding schemes was first performed through an Exploratory Data Analysis (EDA). Statistical significance of this comparison was then established using nonparametric methods. Influence of some other factors on the observers’ performance was also investigated
Farmacogenómica do cancro da mama
Dissertação de mestrado, Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2016O cancro é atualmente a doença mais letal a nível mundial, com 14,1 milhões de novos casos, dos quais resultaram 8,2 milhões de mortes em todo o mundo no ano de 2012. Só em Portugal verificou-se uma taxa de incidência de cancro da mama (bruta), no sexo feminino, de 110,12 por cada 100 mil habitantes. Contudo, tem-se verificado uma tendência positiva no que diz respeito às taxas de sobrevivência, graças à rápida evolução de novos métodos de diagnóstico e terapêutica inovadoras que vão surgindo.
A carcinogénese do cancro da mama envolve, entre outros fatores, modificações genéticas que levam a alterações na função dos genes e que podem, inclusive, ser passadas às gerações seguintes. Este é um tipo de cancro com uma forte componente genética, pelo que atualmente são já conhecidas várias associações entre determinados genes com alelos mutantes, como o gene BRCA1 e o BRCA2, e o risco de desenvolvimento de cancro da mama.
Nos últimos anos tem-se verificado um enorme progresso no tratamento desta doença com o desenvolvimento de fármacos mais seletivos, onde se incluem as terapias hormonais, como tamoxifeno ou os inibidores da aromatase (por exemplo, exemestano), e as terapias biológicas, onde o trastuzumab se inclui.
A Farmacogenómica consiste no estudo dos fatores genéticos que afetam a função ou expressão de produtos génicos envolvidos na farmacocinética e farmacodinâmica de fármacos. Uma vez que existe uma variação muito significativa na resposta aos fármacos e, consequentemente, na taxa de sucesso da terapêutica em indivíduos submetidos a regimes equivalentes, o conceito de “medicina personalizada” tem vindo a ganhar cada vez mais interesse. Esta abordagem terapêutica tem sido implementada através da determinação das variantes genéticas de cada doente a partir de testes genómicos como o MammaPrint® ou o Oncotipo DX®, cujos resultados podem ser usados na seleção do tratamento mais seguro e eficaz de pacientes com cancro da mama
Intervir no património: A Casa dos 24 enquanto paradigma
Este estudo visa descodificar as estratégias de intervenção subjacentes ao projeto da Casa dos 24, da autoria do arquiteto FernandoTávora, por se tratar de uma obra de arquitetura contemporânea localizada numa zona histórica. O caso de estudo proposto é um edifícioem forma de torreão construído junto à Sé do Porto, sobre as ruínasdaquela que tinha sido a antiga Casa da Câmara.Como forma de enquadramento, apresenta-se, numa primeirafase, uma breve análise de alguns escritos de importantes teóricosna área do restauro e reabilitação, assim como documentos considerados essenciais sobre a intervenção nos centros históricos publicados ao longo do século XX. Simultaneamente, realiza-se uma análiseda evolução do percurso profissional do arquiteto Fernando Távora,através da caracterização de algumas obras projetadas em épocasdistintas. Numa segunda fase, documentam-se as transformações doadro da Sé desde as primeiras demolições propostas pela DGEMN,entre os anos 30/40 do século XX, até aos dias de hoje. Numa últimafase, analisa-se, através de uma pesquisa bibliográfica e posterioranálise gráfica, as especificidades da Casa dos 24 enquanto obraarquitetónica.O objetivo desta investigação traduz-se na clarificação das estratégias de intervenção subjacentes à proposta de Fernando Távora,face às polémicas geradas em torno do novo edifício, de caráter claramente contemporâneo e construído a apenas 7 metros de distânciada Sé do Porto.This study aims to decode the intervention strategies underlyingthe project Casa dos 24, designed by the architect Fernando Távorabecause it is a work of contemporary architecture located in a historical area. The proposed case study is a tower-like construction builtnext to the Oporto's Cathedral, on the ruins of what had once been thecity council.First, is presented a brief analysis of some writings of importanttheoreticians in the area of restoration and rehabilitation, as well asdocuments considered essential about intervention in historical centres published during the 20th century. Simultaneously, an analysis ismade of the evolution of the professional career of the architect Fernando Távora, through the characterization of some works projectedat different times. In a second phase, the transformations of the Cathedral churchyard are documented from the first demolitions proposedby the DGEMN, between the years 30/40 of the twentieth century, tothe present day. In a final phase, the specificities of Casa dos 24, asan architectural work, are analyzed through a bibliographical research and later graphic analysis.The objective of this investigation is to clarify the intervention strategies underlying Fernando Távora's proposal, given the controversies surrounding the construction of the new building, which is clearlycontemporary and built only 7 meters away from the Oporto's Cathedral
A case of cycloid psychotic disorder
Based on a case of an acute and transient psychotic disorder with full recovery between recurrences, the authors remind the concept of cycloid psychoses. This diagnosis has been neglected in modern psychiatry and in the current nosological systems. However, the cycloid psychoses concept may offer an alternative diagnosis for some psychotic disorders in spite of the need of more studies to improve the understanding of its etiology and treatment
Estudo sobre a interação entre navios tripulados e navios autónomos
A segurança à semelhança de outros sistemas sociotécnicos no domínio da navegação marítima, está intrinsecamente relacionada ao elemento humano. No âmbito da segurança da navegação, é fundamental compreender os fatores que influenciam a tomada de decisão, a perceção e o comportamento dos indivíduos. A suposição explícita é que, sem humanos na ponte, o “erro humano” desaparecerá. O papel do elemento humano em sistemas sociotécnicos complexos está em constante transformação. O “Estudo da interação entre navios convencionais e navios autónomos” foi objetivado para compreender esses fatores perante a presença, ou não, de navios autónomos.
De forma a conseguir corresponder a todos os objetivos, realizou-se uma fundamentação teórica, onde se abordou o conceito de navios autónomos, os níveis de autonomia e os riscos associados aos navios autónomos. De seguida, efetuou-se uma abordagem ao erro humano, à tomada de decisão e à confiança, juntamente com os fatores que afetam a confiança na automação. Como metodologia, este estudo está sustentado em dados recolhidos através de questionários distribuídos através da plataforma SurveyMonkey e um jogo de cenários simulados coadjuvados com o software Matrix LABoratory (MATLAB), que respondem às perguntas orientadoras. De seguida, utilizando o SPSS 21, procedeu-se a uma análise exploratória de dados.
Com o presente estudo pôde concluir-se que, a introdução dos navios autónomos no domínio marítimo altera: o comportamento dos navegantes; o quadro regulamentar, por exemplo o RIEAM, e a futura formação dos navegantes.The security associated to the resemblance of other sociotechnical systems in the domain of maritime navigation, is essentially related to the human element. When it comes to the security of navigation, it is fundamental to understand the factors that influence decision making, perception and behavior of the individuals. It is assumed that without humans in control, the “Human Error” will disappear. The role of the human element in complex sociotechnical systems is in constant transformation. The “Study of interaction between conventional vessels and autonomous vessels” was created with the goal of understanding these factors in the presence, or not, of autonomous vessels.
In order to achieve all the objectives, a theoretical foundation was created where the concept of autonomous vessels, levels of autonomy and the risks associated to autonomous vessels were addressed. Subsequently, it was taken into account: human error, decision making and confidence, along with the factors that affect the confidence in the automation. Just like methodology, this study is sustained to data acquired through questionnaires distributed through the SurveyMonkey platform and through a game of simulated scenarios assisted with the software Matrix LABoratory (MATLAB), resources which answer fundamental questions. Then, using the SPSS 21, an exploratory data analysis was carried out.
With the present study it was possible to conclude that the introduction of autonomous vessels in the maritime domain changes: the behavior of navigators; the regulatory framework, for example – RIEAM; and the future formation of navigators
The Portuguese National Registry for Hemophilia: Developing of a Web-based Technological Solution
AbstractThe crucial role that patient records have in the management of the rare and chronic diseases greatly increases the need to create mechanisms to facilitate the identification and management of the patient's data. Hemophilia is an X-linked congenital bleeding disorder caused by a deficiency of coagulation factor that affects the population on a ratio of 1 case for 10,000 people born. Currently, there are several countries with technological platforms to support the National Patients’ Registries (NPR) of Hemophilia and other Congenital Coagulopathies (HoCC), due to its benefits in the management of the disease. This work presents the technological platform developed in a joint initiative between the University of Aveiro (UA) and the Portuguese Association of Congenital Coagulopathies (PACC), with the purpose of creating the first NPR with HoCC in Portugal. This web application is hosted in the data center of the University of Aveiro, and is being used by the clinicians of the different Hemophilia Treatment Centers (HTC) across the country
Serious Games for Stroke Telerehabilitation of Upper Limb - A Review for Future Research
Maintaining appropriate home rehabilitation programs after stroke, with proper adherence and remote monitoring is a challenging task. Virtual reality (VR) - based serious games could be a strategy used in telerehabilitation (TR) to engage patients in an enjoyable and therapeutic approach. The aim of this review was to analyze the background and quality of clinical research on this matter to guide future research. The review was based on research material obtained from PubMed and Cochrane up to April 2020 using the PRISMA approach. The use of VR serious games has shown evidence of efficacy on upper limb TR after stroke, but the evidence strength is still low due to a limited number of randomized controlled trials (RCT), a small number of participants involved, and heterogeneous samples. Although this is a promising strategy to complement conventional rehabilitation, further investigation is needed to strengthen the evidence of effectiveness and support the dissemination of the developed solutions
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