26 research outputs found

    Predictive potencies of lung function and exercise variables for the presence of PH.

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    <p>Area under the curve (AUC) values and their confidence interval (95%-CI), sensitivity (SN), specificity (SP), positive (PPV) and negative predictive values (NPV) are given. Diagnostic cut offs in % predicted.</p

    Lung function and gas exchange characteristics of the patient population.

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    <p>Comparison of IPF patients with and without PH. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065643#s3" target="_blank">Results</a> (median and 25<sup>th</sup>; 75<sup>th</sup> percentile) are given as absolute and % predicted values.</p

    Forest plot of meta-analyzed results for the effect per minor allele of rs3748312 on FEV1 in ever-smokers, adjusted for sex, age, height, population stratification factors and the presence of PI S and Z alleles.

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    <p>Studies based on population isolates with a high degree of cryptic relatedness are presented separately. Effect estimates of meta-analyses are shown with green diamonds. I<sup>2</sup> is a measure of the heterogeneity between studies. Random effect meta-analyses are included if I<sup>2</sup>>0.5. Study weights (blue squares) correspond to fixed effect meta-analyses.</p

    The ten most strongly associated SNPs in the unconditional GWAS on AAT serum level in SAPALDIA (N = 1392).

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    <p>Abbreviations: AAT, alpha1-antitrypsin; GWAS, genome-wide association study; MAF, minor allele frequency; SNP, single nucleotide polymorphism.</p><p>Imp-r<sup>2</sup> is an indicator for imputation quality. SNPs with MAF<0.05 or imp-r<sup>2</sup><0.5 were excluded.</p><p>Chromosomal position is based on reference panel, NCBI build 36.3. Allele effects are shown in absolute numbers.</p

    LD plot among common and low-frequent SNPs in the <i>SERPINA1</i> gene within the SAPALDIA study.

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    <p>Shading represent r<sup>2</sup> values, whereas numbers represent D′ values (no number equals D′ = 1). Red framed SNPs are independently associated with AAT serum levels after forward selection stepwise regression modeling. Rs17580 is the PI S variant and rs28929474 is the PI Z variant.</p

    The ten most strongly associated SNPs in the GWAS on AAT serum level, conditional on PI S and PI Z alleles in SAPALDIA (N = 1392).

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    <p>Abbreviations: AAT, alpha1-antitrypsin; GWAS, genome-wide association study; MAF, minor allele frequency; SNP, single nucleotide polymorphism.</p><p>Imp-r<sup>2</sup> is an indicator for imputation quality. SNPs with MAF<0.05 or imp-r<sup>2</sup><0.5 were excluded.</p><p>Chromosomal position is based on reference panel, NCBI build 36.3. Allele effects are shown in absolute numbers.</p
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