26 research outputs found
Predictive potencies of lung function and exercise variables for the presence of PH.
<p>Area under the curve (AUC) values and their confidence interval (95%-CI), sensitivity (SN), specificity (SP), positive (PPV) and negative predictive values (NPV) are given. Diagnostic cut offs in % predicted.</p
Survival of 133 patients with IPF with and without interceding pulmonary hypertension.
<p>Non-PH (blue line), PH (orange line).</p
Lung function and gas exchange characteristics of the patient population.
<p>Comparison of IPF patients with and without PH. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065643#s3" target="_blank">Results</a> (median and 25<sup>th</sup>; 75<sup>th</sup> percentile) are given as absolute and % predicted values.</p
Forest plot of meta-analyzed results for the effect per minor allele of rs3748312 on FEV1 in ever-smokers, adjusted for sex, age, height, population stratification factors and the presence of PI S and Z alleles.
<p>Studies based on population isolates with a high degree of cryptic relatedness are presented separately. Effect estimates of meta-analyses are shown with green diamonds. I<sup>2</sup> is a measure of the heterogeneity between studies. Random effect meta-analyses are included if I<sup>2</sup>>0.5. Study weights (blue squares) correspond to fixed effect meta-analyses.</p
The ten most strongly associated SNPs in the unconditional GWAS on AAT serum level in SAPALDIA (N = 1392).
<p>Abbreviations: AAT, alpha1-antitrypsin; GWAS, genome-wide association study; MAF, minor allele frequency; SNP, single nucleotide polymorphism.</p><p>Imp-r<sup>2</sup> is an indicator for imputation quality. SNPs with MAF<0.05 or imp-r<sup>2</sup><0.5 were excluded.</p><p>Chromosomal position is based on reference panel, NCBI build 36.3. Allele effects are shown in absolute numbers.</p
Manhattan plot of genome-wide -log(10) p-values for association with AAT serum level, conditional on PI S and PI Z alleles.
<p>Manhattan plot of genome-wide -log(10) p-values for association with AAT serum level, conditional on PI S and PI Z alleles.</p
Minor allele effects of PI S, PI Z and rs4905179 on AAT serum levels in the Copenhagen City Heart Study.
<p>Abbreviations: MAF, minor allele frequency; SNP, single nucleotide polymorphism.</p
Manhattan plot of genome-wide -log(10) p-values for association with AAT serum level.
<p>SNPs reaching genome-wide significance are shown in green. They all belong to the <i>SERPINA</i> gene cluster.</p
LD plot among common and low-frequent SNPs in the <i>SERPINA1</i> gene within the SAPALDIA study.
<p>Shading represent r<sup>2</sup> values, whereas numbers represent D′ values (no number equals D′ = 1). Red framed SNPs are independently associated with AAT serum levels after forward selection stepwise regression modeling. Rs17580 is the PI S variant and rs28929474 is the PI Z variant.</p
The ten most strongly associated SNPs in the GWAS on AAT serum level, conditional on PI S and PI Z alleles in SAPALDIA (N = 1392).
<p>Abbreviations: AAT, alpha1-antitrypsin; GWAS, genome-wide association study; MAF, minor allele frequency; SNP, single nucleotide polymorphism.</p><p>Imp-r<sup>2</sup> is an indicator for imputation quality. SNPs with MAF<0.05 or imp-r<sup>2</sup><0.5 were excluded.</p><p>Chromosomal position is based on reference panel, NCBI build 36.3. Allele effects are shown in absolute numbers.</p