2,263 research outputs found

    Kurdish Minority Politics in Iraq

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    Green Vertical Neighborhood (studi su quartiere verticale verde a tipologi residentiali verticali)

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    Designing the green vertical neighborhood or green vertical community has come up to be investigated not so long ago. In an integrated research project I tried to study and develop the concept of green neighborhood narrowly in vertical orientation. Fundamentally residential buildings and high rise residential buildings have been set as the vehicles for this research. Having established a pragmatic framework I took into account the meaning and definitions around many terms like green movements, dwelling, residential building, high rise building, neighborhood, responsive environment and sustainability. The background and theoretical studies have been considered historically and the different points of view have been distinguished accurately. Naturally the scale of neighborhood unit studies varies through macro (urban), mid (district) and micro (architecture).Several similar case studies around the world have been set to be analyzed according to the research process goals and finally these case studies built the ultimate outcomes. Consequently an integrated sustainable model of green vertical neighborhood guidelines is offered based on the theory of Ken Yeang about green vertical building design. Pushing forward the previous model of Yeang’ theory and setting a new critical framework in order to Improve the life quality in residential buildings regarding the responsive guidelines of green vertical neighborhood for high rise buildings is the main goal of this research

    Kurdish Minority Politics in Iraq

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    COGNITIVE BEHAVIOR THERAPY AND ITS IMPACT

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    The focus of the study was to test the influence of cognitive behavior therapy on parents with disable children. For this purpose, we used the experiment method and measured quality of life of parents with disable children before and after administration of cognitive behavior therapy. The methodology of the study was quantitative, experimental, survey based, and before-and-after research design. In this design, the quality of life was considered as an independent variable and the administration of the cognitive behavior therapy as independent variable or as an intervention. The duration of therapy was 2 months based on 2 times in a week on regular basis. the therapy was administered in a hospital in Dhaka, Bangladesh based on an NGO funded project. The results showed that parents with disable children showed significant improvement in psychological, social relationship, and environment domains of quality of life after receiving the behavior cognitive therapy. the results for the physical health dimension turned out to be insignificant. The study concludes that parents with disable children may be provided cognitive behavior therapy in order to improve their quality of lif

    Active Learning for Classifying 2D Grid-Based Level Completability

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    Determining the completability of levels generated by procedural generators such as machine learning models can be challenging, as it can involve the use of solver agents that often require a significant amount of time to analyze and solve levels. Active learning is not yet widely adopted in game evaluations, although it has been used successfully in natural language processing, image and speech recognition, and computer vision, where the availability of labeled data is limited or expensive. In this paper, we propose the use of active learning for learning level completability classification. Through an active learning approach, we train deep-learning models to classify the completability of generated levels for Super Mario Bros., Kid Icarus, and a Zelda-like game. We compare active learning for querying levels to label with completability against random queries. Our results show using an active learning approach to label levels results in better classifier performance with the same amount of labeled data.Comment: 4 pages, 3 figure

    Expressing Fear via Intonation in Kurdish with Special Reference to English

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    Intonation is an inseparable part of human speech. It can perform several functions. One of these functions is the expression of attitudes or emotions, among them is fear. The present research paper investigates the relation between intonation and expressing fear both in Kurdish and English. To achieve this aim, the study endeavours to clarify the intonation patterns used to express fear by depending on seven variables: the tone, the height of the pre-head and the head, the width of pitch range, the key, and markedness. In addition, references are also made to other prosodic and paralinguistic features which are also integral parts of speech and important factors for the expression of emotions. The study elaborates the function in question in Kurdish by drawing and thoroughly describing the diagrammatic representations of twenty-two selected tone-groups of various syntactic structures. Whereas in English, the relation between intonation and fear depends on the literature available. One of the most important conclusions which can be drawn from the study is that fear is carried out mostly by the falling tone, either from high to mid or mid to low, and a narrow pitch range as well as the accompaniment of whispering and shivering as paralinguistic features. Keywords: Intonation, Attitudinal functions, Emotions, Fear, Pitch rang

    OPHTHALMIC IN-SITU SUSTAINED GEL OF CIPROFLOXACIN, PREPARATION AND EVALUATION STUDY

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    Objective: This work aims to formulate and evaluate an ophthalmic in-situ gel of ciprofloxacin hydrochloride (HCl) using poloxamer 407 (P407) as a gelling agent and hydroxypropyl methylcellulose (HPMC) as a viscosity modifier. The objective of this work was to prolong the contact time as the in-situ gel will be converted into a gel upon contact with the cul-de-sac. Methods: Ciprofloxacin HCl ophthalmic in-situ gel was prepared by utilizing (P407) as a temperature-dependent polymer while hydroxypropyl methylcellulose was used as a viscosity modifier. The system was evaluated for physical appearance, pH, drug content, sterility, irritancy and stability. In addition, gelation temperature and a viscosity at different shear rates and different temperatures were studied. The compatibility of the polymer with ciprofloxacin was studied by using fourier transform infrared spectroscopy (FTIR). The in vitro release of the drug was also evaluated and supported by a preliminary in vivo test.Results: The results showed that the prepared formulas were clear, with acceptable pH and the drug contents were within the acceptable limits. FTIR results detected no incompatibility between poloxamer 407 and ciprofloxacin HCl. Notably, the viscosity of the system showed a pseudoplastic behaviour where a reduction in viscosity upon increasing the shear rate was observed. The in vitro release study confirmed the prolongation of the release of the optimized formula (F6) up to 8 h. Upon application of F6 into eyes of rabbits there was no irritancy. In addition, in vivo elimination study showed a prolonged contact for the in-situ gel in comparison with the rapid clearance of eye drop. Stability study indicated the stability of the optimized formula (F6). Conclusion: The prepared optimized formula (F6) represents a successful, safe, stable and prolonged release in-situ gel formula of ciprofloxacin

    Depth and Distance Perceptions within Virtual Reality Environments. A Comparison between HMDs and CAVEs in Architectural Design

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    The Perceptions of Depth and Distance are considered as two of the most important factors in Virtual Reality Environments, as these environments inevitability impact the perception of the virtual content compared with the one of the real world. Many studies on depth and distance perceptions in a virtual environment exist. Most of them were conducted using Head-Mounted Displays (HMDs) and less with large screen displays such as those of Cave Automatic Virtual Environments (CAVEs). In this paper, we make a comparison between the different aspects of perception in the architectural environment between CAVE systems and HMD. This paper clarifies the Virtual Object as an entity in a VE and also the pros and cons of using CAVEs and HMDs are explained. Eventually, just a first survey of the planned case study of the artificial port of the Trajan emperor near Fiumicino has been done as for COVID-19 an on-field experimentation could not have been performed

    Apoptosis Induction with Enhancement of BAX/BCL2 Gene Expression Ratio via Combination Therapy in HT29 Colon Cancer Cells

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    Background and Aim: Combination therapy is one of the new strategies that minimize resistance to chemotherapy and reduces drug toxicity. Here, we investigated the effect of combination therapy with 5-Fluorouracil and Gamma Tocopherol on cell survival and BAX/BCL2 gene expression ratio in HT29 colon cancer cells. Methods: The proliferation of cancer cells was determined via colony formation assay. BAX/BCL2 ratio was evaluated after incubation with concentrations of 5-Fluorouracil and Gamma Tocopherol via real-time-PCR. Results: The average number of colonies in the cells treated with 5-Fluorouracil, Gamma Tocopherol and their combination of them was 63±4, 78±3, and 28±2, respectively which significantly decreased in the combination group. In contrast with the control group, the BAX/BCL2 ratio remarkably increased when the cell underwent combinational treatment (p<0.05). Conclusion: 5-Fluorouracil and Gamma Tocopherol reduced HT 29 cell proliferation. Our results suggest that combination therapy with 5- Fluorouracil and Gamma Tocopherol can be considered as a strategy for induction of apoptosis via increasing the BAX/BCL2 ratio. *Corresponding Author: Nadereh Rashtchizadeh; Email: [email protected] Please cite this article as: Bazzaz R, Yaghmaei P, Dastmalchi S, Rashtchizadeh N. Apoptosis Induction with Enhancement of BAX/BCL2 Gene Expression Ratio via Combination Therapy in HT29 Colon Cancer Cells. Arch Med Lab Sci. 2020;6:1-7 (e21). https://doi.org/10.22037/amls.v6.3348
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