Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton

Carbothioamides 4a,b, obtained from nalidixic acid, were converted to the corresponding 1,3-thiazolidine derivatives 5a,b by cyclocondensation with 2-bromo-1-(4-chlorophenyl)ethanone. Treatment of 4a,b with base afforded 1,2,4-triazoles 6a,b. The synthesis of 1,3-oxazolidine 7 was performed by the reaction of compound 4a with ethyl bromoacetate. Treatment of 4a with acid produced 1,3,4-thiadiazole 8. The reaction of compounds 6a and 6b with several heterocyclic amines in the presence of formaldehyde gave the corresponding Mannich bases 9–15 containing various pharmacophore groups. Conventional and microwave-assisted methods were used for the synthesis. The effect of an acid catalyst on Mannich reactions was investigated. The structures of the newly synthesized compounds were elucidated on the basis of 1H NMR, 13C NMR, FTIR, EIMS techniques, and elemental analysis. All compounds were screened for their antimicrobial activity

Diagnosis and management of carotid body tumor: a report of seven cases

Bozok, Sahin/0000-0002-1256-5055WOS: 000314377200038Paragangliomas are rare asymptomatic painless tumors, originating from paraganglionic bodies of autonomous nerve system of the embriological neural crest and increasing gradually. Despite their gradual developing nature, it is critical to reach early diagnosis and tailor surgical plan for carotid body tumors due to their potential of being malignant and local aggressive development, as well as invasion or pressure on the adjacent vascular and neural tissues. in this article, we present seven cases who were admitted with the complaints of pain and swelling in the neck and were diagnosed with carotid body tumor based on the further investigations and were surgically treated in the light of literature review and different surgical modalities were discussed

Closed Fracture of the Medial Malleolus Accompanied by A Rupture of the Tibialis Anterior Tendon: An Unusual Case Report

Isolated medial malleolus fractures comprise two-thirds of all ankle fractures and are rarely accompanied by a posterior tibial tendon rupture and dislocation. However, a medial malleolus fracture accompanied by an anterior tibial tendon rupture is unusual, and has not yet been reported. In this paper, a case of medial malleolus fracture accompanied by a tibialis anterior tendon rupture is presented and discussed

Rivaroxaban ­an anticoagulant agent­ appears to have a role in reversing the hypoxia­ induced metabolic adaptation observed in colorectal cancer cell lines

The pro­coagulant activity of cancer is known for its ability to induce FXa and thrombin. FXa promotes cancer growth and metastasis via PAR, according to recent literature reports. This study aimed to investigate the effect of the inhibition of FXa, which is known to play a crucial role in cancer metabolism in hypoxia, on the behaviour of colon cancer cell lines HCT­116 and HT­29. We performed studies under both normoxic and hypoxic conditions. We used immunofluorescence to assess the expression of key elements in tumor metabolism, including HIF­1 alpha, LDH­A and GLUT­1, following administration of rivaroxaban, an FXa inhibitor known to not affect cell viability. The expression of HIF­1 and LDH­A increased under hypoxia. However, it was observed that the expression decreased in the rivaroxaban­ treated group. Strikingly, no statistically significant difference was found for GLUT­1 expression. Furthermore, in the analysis of E­cadherin and N­cadherin expression levels, the effect of rivaroxaban on migration under hypoxia was statistically significant in comparison to the control group. These findings were further supported by the statistical results of the wound patency in the wound healing experiment. Based on the results of this study, we demonstrate that the inhibition of FXa with rivaroxaban may represent a novel target for the treatment of tumor hypoxia. (O.B. supported by the CoHE 100/2000 project. The study is funded by Dokuz Eylul University Scientific Research Projects Coordination Unit with project number TSG­2022­2576).</div