1 research outputs found
Ultrasmall Gold Nanoparticles Radiolabeled with Iodine-125 as Potential New Radiopharmaceutical
The relatively high
linear energy transfer of Auger electrons,
which can cause clustered DNA damage and hence efficient cell death,
makes Auger emitters excellent candidates for attacking metastasized
tumors. Moreover, gammas or positrons are usually emitted along with
the Auger electrons, providing the possibility of theragnostic applications.
Despite the promising properties of Auger electrons, only a few radiopharmaceuticals
employing Auger emitters have been developed so far. This is most
likely explained by the short ranges of these electrons, requiring
the delivery of the Auger emitters to crucial cell parts such as the
cell nucleus. In this work, we combined the Auger emitter 125I and ultrasmall gold nanoparticles to prepare a novel radiopharmaceutical.
The 125I labeled gold nanoparticles were shown to accumulate
at the cell nucleus, leading to a high tumor-killing efficiency in
both 2D and 3D tumor cell models. The results from this work indicate
that ultrasmall nanoparticles, which passively accumulate at the cell
nucleus, have the potential to be applied in targeted radionuclide
therapy. Even better tumor-killing efficiency can be expected if tumor-targeting
moieties are conjugated to the nanoparticles