38 research outputs found
Optically programmable gate array
Get PDFThe Optically Programmable Gate Array (OPGA), an optical version of a conventional FPGA, benefits from a direct parallel interface between an optical memory and a logic circuit. The OPGA utilizes a holographic memory accessed by an array of VCSELs to program its logic. An active pixel sensor array incorporated into the OPGA chip makes it possible to optically address the logic in a very short time allowing for rapid dynamic reconfiguration. Combining spatial and shift multiplexing to store the configuration pages in the memory, the OPGA module can be made compact. The reconfiguration capability of the OPGA can be applied to solve more efficiently problems in pattern recognition and database search
Limitations and pitfalls of 99mTc-EDDA/HYNIC-TOC (Tektrotyd) scintigraphy
Get PDFTektrotyd kit was developed by Polatom company for 99mTc labeling to make an alternative tracer of somatostatin receptor scintigraphy available. Since 2005, 99mTc-EDDA/HYNIC-Tyr3-Octreotide has been used in clinical imaging and achieved high impact in management of patients with neuroendocrine tumors. Knowing the limitations and pitfalls is essential to provide accurate diagnosis. Therefore, the potential pitfalls associated with the use of 99mTc-EDDA/HYNIC-TOC are reviewed on the basis of own experience. Data were analyzed of 310 patients who underwent somatostatin receptor scintigraphy with 99mTc-Tektrotyd. Pitfalls during radiolabeling process or acquisition can worsen the sensitivity of SRS (somatostatin receptor scintigraphy). Recognizing physiological and clinical pitfalls, the diagnostic accuracy will improve
Optically programmable gate array
Get PDFThe Optically Programmable Gate Array (OPGA), an optical version of a conventional FPGA, benefits from a direct parallel interface between an optical memory and a logic circuit. The OPGA utilizes a holographic memory accessed by an array of VCSELs to program its logic. An active pixel sensor array incorporated into the OPGA chip makes it possible to optically address the logic in a very short time allowing for rapid dynamic reconfiguration. Combining spatial and shift multiplexing to store the configuration pages in the memory, the OPGA module can be made compact. The reconfiguration capability of the OPGA can be applied to solve more efficiently problems in pattern recognition and database search
High Fat High Sucrose Diet Modifies Uterine Contractility and Cervical Resistance in Pregnant Rats: The Roles of Sex Hormones, Adipokines and Cytokines
Get PDFCanagliflozin and renal outcomes in type 2 diabetes and nephropathy
Get PDFBACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
OutIntSys - A Novel Method for the Detection of the Most Intelligent Cooperative Multiagent Systems
Full text linkEvaluation of the tear clearance rate by dacryoscintigraphy in patients with obstructive meibomian gland dysfunction
Full text linkClinical utility of SPECT/CT and CT-dacryocystography-enhanced dacryoscintigraphy in the imaging of lacrimal drainage system obstruction
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Dual archive paleotemperature records over two pre-LGM stadial/interstadials in East Central Europe
No full text&lt;p&gt;The generally cold climate of the last glacial period was interrupted by numerous abrupt shifts to warmer interstadial conditions in the North Atlantic. The effects of this Dansgaard&amp;#8211;Oeschger (D&amp;#8211;O) type climatic variability have been found in a number of European and Asian terrestrial paleoclimate archives, including speleothems, lakes and loess deposits. However, only very few of the already sparse precisely dated records provide quantitative information on stadial-interstadial temperature variations over this time period. This is a major impediment to resolving the cause and geographical propagation of D-O events, as well as to understanding the impact they have on continental climates and environments.&lt;/p&gt;&lt;p&gt;Here we present carbonate clumped isotope (&lt;em&gt;&amp;#916;&lt;sub&gt;47&lt;/sub&gt;&lt;/em&gt;)-based active season paleotemperature (AST) estimates from land snails recovered from Greenland Stadial/Interstadial (GS/GI) 5 and 3 age loess at the Dunaszekcs&amp;#337; loess site (Hungary), based on a uniquely detailed AMS &lt;sup&gt;14&lt;/sup&gt;C age dataset, alongside a new flowstone (PK-6, B&amp;#252;kk&amp;#246;sd, Hungary) stable isotope-based temperature change record &lt;sup&gt;230&lt;/sup&gt;Th-dated to 30-26 ka. Stadial ASTs of the investigated periods were found to be in the range of 7&amp;#8211;13 &amp;#176;C, corresponding to &lt;em&gt;T&lt;sub&gt;annual&lt;/sub&gt;&lt;/em&gt; of 0&amp;#8211;6 &amp;#176;C and &lt;em&gt;T&lt;sub&gt;July&lt;/sub&gt;&lt;/em&gt; of 11&amp;#8211;17 &amp;#176;C, agreeing well with the range of model simulation results for the region. Interstadial AST values reconstructed for GI-5.1 and 3 (16&amp;#8211;18 &amp;#176;C) indicate warm summers (&lt;em&gt;T&lt;sub&gt;July&lt;/sub&gt;&lt;/em&gt;: 20&amp;#8211;22 &amp;#176;C) and relatively high annual mean temperatures (&lt;em&gt;T&lt;sub&gt;annual&lt;/sub&gt;&lt;/em&gt;: 9&amp;#8211;11 &amp;#176;C), matching present-day values. The PK-6 flowstone &amp;#948;&lt;sup&gt;18&lt;/sup&gt;O&lt;sub&gt;calcite&lt;/sub&gt;-based temperature change estimates (~0.2 &amp;#8240; &amp;#176;C&lt;sup&gt;&amp;#8211;1 &lt;/sup&gt;&amp;#948;&lt;sup&gt;18&lt;/sup&gt;O/T gradient) reveal a 7&amp;#8211;10 &amp;#176;C &lt;em&gt;T&lt;sub&gt;annual&lt;/sub&gt;&lt;/em&gt; rise for the warmest phases of GI-3 and 4 compared to stadial temperatures, in very good agreement with the land snail &lt;em&gt;T&amp;#916;&lt;sub&gt;47&lt;/sub&gt;&lt;/em&gt; values.&lt;/p&gt;&lt;p&gt;Our results show that stadial-interstadial climate variability in East Central Europe was of comparable magnitude to that in Greenland. We propose that large scale ocean-atmospheric variability (NAO-AMO) imparts a major control on transmitting abrupt North Atlantic climate event signals into continental Europe during the last glacial.&lt;/p&gt;&lt;p&gt;&amp;#160;&lt;/p&gt;&lt;p&gt;This study was funded by the Hungarian National Research, Development and Innovation Office to G&amp;#218; (OTKA PD-108639) and SK (OTKA KH-125584). TS is grateful for the support of the Swedish Research Council (2017-03888).&lt;/p&gt;</jats:p
