Active Multiple Plasmon-Induced Transparency with Graphene Sheets Resonators in Mid-Infrared Frequencies

A multiple plasmon-induced transparency (PIT) device operated in the mid-infrared region has been proposed. The designed model is comprised of one graphene ribbon as main waveguide and two narrow graphene sheets resonators. The phase coupling between two graphene resonators has been investigated. The multimode PIT resonances have been found in both cases and can be dynamically tuned via varying the chemical potential of graphene resonators without optimizing its geometric parameters. In addition, this structure can get multiple PIT effect by equipping extra two sheets on the symmetric positions of graphene waveguide. The simulation results based on finite element method (FEM) are in good agreement with the resonance theory. This work may pave new way for graphene-based thermal plasmonic devices applications

Interest-Aware Joint Caching, Computing, and Communication Optimization for Mobile VR Delivery in MEC Networks

In the upcoming B5G/6G era, virtual reality (VR) over wireless has become a typical application, which is an inevitable trend in the development of video. However, in immersive and interactive VR experiences, VR services typically exhibit high delay, while simultaneously posing challenges for the energy consumption of local devices. To address these issues, this paper aims to improve the performance of the VR service in the edge-terminal cooperative system. Specifically, we formulate a problem of joint caching, computing, and communication VR service policy, by optimizing the weighted sum of overall VR delivery delay and energy consumption of local devices. For the purpose of designing the optimal VR service policy, the optimization problem is decoupled into three independent subproblems to be solved separately. To enhance the caching efficiency within the network, a bidirectional encoder representations from transformers (Bert)-based user interest analysis method is first proposed to characterize the content requesting behavior accurately. On the basis of this, a service cost minimum-maximization problem is formulated with consideration of performance fairness among users. Thereafter, the joint caching and computing scheme is derived for each user with given allocation of communication resources while a bisection-based communication scheme is acquired with the given information on joint caching and computing policy. With alternative optimization, an optimal policy for joint caching, computing and communication based on user interest can be finally obtained. Simulation results are presented to demonstrate the superiority of the proposed user interest-aware caching scheme and the effective of the joint caching, computing and communication optimization policy with consideration of user fairness

Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion

Regulatory T (Treg) cells contribute to immune homeostasis but suppress immune responses to cancer. Strategies to disrupt Treg cell–mediated cancer immunosuppression have been met with limited clinical success, but the underlying mechanisms for treatment failure are poorly understood. By modeling Treg cell–targeted immunotherapy in mice, we find that CD4+ Foxp3− conventional T (Tconv) cells acquire suppressive function upon depletion of Foxp3+ Treg cells, limiting therapeutic efficacy. Foxp3− Tconv cells within tumors adopt a Treg cell–like transcriptional profile upon ablation of Treg cells and acquire the ability to suppress T cell activation and proliferation ex vivo. Suppressive activity is enriched among CD4+ Tconv cells marked by expression of C-C motif receptor 8 (CCR8), which are found in mouse and human tumors. Upon Treg cell depletion, CCR8+ Tconv cells undergo systemic and intratumoral activation and expansion, and mediate IL-10–dependent suppression of antitumor immunity. Consequently, conditional deletion of Il10 within T cells augments antitumor immunity upon Treg cell depletion in mice, and antibody blockade of IL-10 signaling synergizes with Treg cell depletion to overcome treatment resistance. These findings reveal a secondary layer of immunosuppression by Tconv cells released upon therapeutic Treg cell depletion and suggest that broader consideration of suppressive function within the T cell lineage is required for development of effective Treg cell–targeted therapies

Detuned Plasmonic Bragg Grating Sensor Based on a Defect Metal-Insulator-Metal Waveguide

A nanoscale Bragg grating reflector based on the defect metal-insulator-metal (MIM) waveguide is developed and numerically simulated by using the finite element method (FEM). The MIM-based structure promises a highly tunable broad stop-band in transmission spectra. The narrow transmission window is shown to appear in the previous stop-band by changing the certain geometrical parameters. The central wavelengths can be controlled easily by altering the geographical parameters. The development of surface plasmon polarition (SPP) technology in metallic waveguide structures leads to more possibilities of controlling light at deep sub-wavelengths. Its attractive ability of breaking the diffraction limit contributes to the design of optical sensors