Introducing new diagnostics into STI control programmes: the importance of programme science.

Many innovative diagnostic technologies will become commercially available over the next 5-10 years. These tests can potentially transform the diagnosis of sexually transmitted infections but their introduction into control programmes can be hampered by health system constraints, and political, cultural, socioeconomic and behavioural factors. We used the introduction of syphilis rapid tests to illustrate the importance of programme science to address the gap between accruing evidence of acceptable test performance and the complexity of programme design, implementation and evaluation of test deployment to address public health needs and improve patient-important outcomes

THE KEPLER DICHOTOMY IN PLANETARY DISKS: LINKING KEPLER OBSERVABLES TO SIMULATIONS OF LATE-STAGE PLANET FORMATION

NASA's Kepler Mission uncovered a wealth of planetary systems, many with planets on short-period orbits. These short-period systems reside around 50% of Sun-like stars and are similarly prevalent around M dwarfs. Their formation and subsequent evolution is the subject of active debate. In this paper, we simulate late-stage, in situ planet formation across a grid of planetesimal disks with varying surface density profiles and total mass. We compare simulation results with observable characteristics of the Kepler sample. We identify mixture models with different primordial planetesimal disk properties that self-consistently recover the multiplicity, radius, period and period ratio, and duration ratio distributions of the Kepler planets. We draw three main conclusions. (1) We favor a "frozen-in" narrative for systems of short-period planets, in which they are stable over long timescales, as opposed to metastable. (2) The "Kepler dichotomy," an observed phenomenon of the Kepler sample wherein the architectures of planetary systems appear to either vary significantly or have multiple modes, can naturally be explained by formation within planetesimal disks with varying surface density profiles. Finally, (3) we quantify the nature of the "Kepler dichotomy" for both GK stars and M dwarfs, and find that it varies with stellar type. While the mode of planet formation that accounts for high multiplicity systems occurs in 24% ± 7% of planetary systems orbiting GK stars, it occurs in 63% ± 16% of planetary systems orbiting M dwarfs.United States. National Aeronautics and Space Administration (NASA grant NNX12AC01G)Massachusetts Institute of Technology (Torres Fellowship for Exoplanet Research)

The relationship between the Last Planner® System and collaborative planning practice in UK construction

Purpose – The purpose of this study is to identify how the newly emerging UK practice of "Collaborative Planning" (CP) for construction project delivery aligns with the advocated principles of the Last Planner System (LPS) of production planning and control. Design/methodology/approach – A mixed, qualitative, exploratory approach was adopted for the study. This entailed qualitative data through three techniques namely: semi-structured interviews, documents analysis, and structured observation. Thirty in-depth-interviews were conducted over a 12 month period with lean construction consultants, clients, main contractors, and subcontractors drawn from the building, highways and infrastructure and rail sector. Fifteen projects were visited where practices were observed. Findings – The study reveals that the current practice of CP in the UK partially aligns with the LPS principles. Where practitioners have heard of the LPS they believe it to be the same practice as CP. Limitation: This study is limited to 30 interviews, observation of 15 projects and document analysis. The aim of the study is not to generalise the findings, however, since the study examined top construction companies and practitioners in the UK and the findings were consistent across the sample, some conclusions could be made. The study is also limited to examining the construction phase only, future studies should incorporate the design phase. Practical Implication - A clear identification of the elements of current practice compared to the components of the LPS provides a contribution to the future practice of project production planning and management in the construction industry. Social implication – The study highlights a continuing resistance to collaboration within the industry. This resistance is subtly embedded within implemented practices even though they are based on collaborative working for their success. Originality and Value – This is among the first studies in the UK that comprehensively examines and reports the application of Last Planner System/Collaborative Planning practice in construction across the major construction sectors. Future studies could build on the findings from this work to develop an approach/methodology to improve the current practice

Software for Use with Optoelectronic Measuring Tool

A computer program has been written to facilitate and accelerate the process of measurement by use of the apparatus described in "Optoelectronic Tool Adds Scale Marks to Photographic Images" (KSC-12201). The tool contains four laser diodes that generate parallel beams of light spaced apart at a known distance. The beams of light are used to project bright spots that serve as scale marks that become incorporated into photographic images (including film and electronic images). The sizes of objects depicted in the images can readily be measured by reference to the scale marks. The computer program is applicable to a scene that contains the laser spots and that has been imaged in a square pixel format that can be imported into a graphical user interface (GUI) generated by the program. It is assumed that the laser spots and the distance(s) to be measured all lie in the same plane and that the plane is perpendicular to the line of sight of the camera used to record the imag

Periodically Varying Externally Imposed Environmental Effects on Population Dynamics

Effects of externally imposed periodic changes in the environment on population dynamics are studied with the help of a simple model. The environmental changes are represented by the temporal and spatial dependence of the competition terms in a standard equation of evolution. Possible applications of the analysis are on the one hand to bacteria in Petri dishes and on the other to rodents in the context of the spread of the Hantavirus epidemic. The analysis shows that spatio-temporal structures emerge, with interesting features which depend on the interplay of separately controllable aspects of the externally imposed environmental changes.Comment: 7 pages, 8 figures, include

Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence.

BackgroundIndividuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions. Indirect evidence suggests that low dopamine D2-type receptor availability in the striatum contributes to the propensity of these individuals to sacrifice long-term goals for short-term gain; however, this possibility has not been tested directly. We investigated whether striatal D2/D3 receptor availability is negatively correlated with the preference for smaller, more immediate rewards over larger, delayed alternatives among research participants who met DSM-IV criteria for methamphetamine (MA) dependence.MethodsFifty-four adults (n = 27 each: MA-dependent, non-user controls) completed the Kirby Monetary Choice Questionnaire, and underwent positron emission tomography scanning with [(18)F]fallypride.ResultsMA users displayed steeper temporal discounting (p = 0.030) and lower striatal D2/D3 receptor availability (p < 0.0005) than controls. Discount rate was negatively correlated with striatal D2/D3 receptor availability, with the relationship reaching statistical significance in the combined sample (r = -0.291, p = 0.016) and among MA users alone (r = -0.342, p = 0.041), but not among controls alone (r = -0.179, p = 0.185); the slopes did not differ significantly between MA users and controls (p = 0.5).ConclusionsThese results provide the first direct evidence of a link between deficient D2/D3 receptor availability and steep temporal discounting. This finding fits with reports that low striatal D2/D3 receptor availability is associated with a higher risk of relapse among stimulant users, and may help to explain why some individuals choose to continue using drugs despite knowledge of their eventual negative consequences. Future research directions and therapeutic implications are discussed

Evaluation of a Head-Worn Display with Ambient Vision Cues for Unusual Attitude Recovery

A Commercial Aviation Safety Team (CAST) study of 18 loss-of-control events determined that a lack of external visual references was a contributing factor in 17 of these events. CAST recommended that manufacturers should develop and implement virtual day-VMC display systems, such as synthetic vision (SV) or equivalent systems (CAST Safety Enhancement, SE-200). In support of this recommended action, CAST has requested studies to define minimum requirements for virtual day-visual meteorological conditions (VMC) displays to improve flight crew awareness of airplane attitude. NASAs research in Virtual day-VMC displays, known as synthetic vision systems, are intended to support intuitive flight crew attitude awareness similar to a day-VMC-like environment, especially if they could be designed to create visual dominance. A study was conducted to evaluate the utility of ambient vision (AV) cues paired with virtual Head-Up Display (HUD) symbology on a prototype head-worn display (HWD) during recovery from unusual attitudes in a simulated environment. The virtual-HUD component meets the requirement that the HWD may be used as an equivalent display to the HUD. The presence of AV cueing leverages the potential that a HWD has over the HUD for spatial disorientation prevention. The simulation study was conducted as a single-pilot operation, under realistic flight scenarios, with off-nominal events occurring that were capable of inducing unusual attitudes. Independent variables of the experiment included: 1) AV capability (on vs off) 2) AV display opaqueness (transparent vs opaque) and display location (HWD vs traditional head- down displays); AV cues were only present when the HWD was being worn by the subject pilot

Degeneracy in the characterization of non-transiting planets from transit timing variations

The transit timing variation (TTV) method allows the detection of non-transiting planets through their gravitational perturbations. Since TTVs are strongly enhanced in systems close to mean-motion resonances (MMR), even a low mass planet can produce an observable signal. This technique has thus been proposed to detect terrestrial planets. In this letter, we analyse TTV signals for systems in or close to MMR in order to illustrate the difficulties arising in the determination of planetary parameters. TTVs are computed numerically with an n-body integrator for a variety of systems close to MMR. The main features of these TTVs are also derived analytically. Systems deeply inside MMR do not produce particularly strong TTVs, while those close to MMR generate quasiperiodic TTVs characterised by a dominant long period term and a low amplitude remainder. If the remainder is too weak to be detected, then the signal is strongly degenerate and this prevents the determination of the planetary parameters. Even though an Earth mass planet can be detected by the TTV method if it is close to a MMR, it may not be possible to assert that this planet is actually an Earth mass planet. On the other hand, if the system is right in the center of a MMR, the high amplitude oscillation of the TTV signal vanishes and the detection of the perturber becomes as difficult as it is far from MMR.Comment: 5 pages, 3 figures, submitted to MNRA