2,666 research outputs found

    Mutagenicity and Carcinogenicity Prediction of Compounds from Cardamom (\u3cem\u3eElettaria cardamom\u3c/em\u3e Maton)

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    In silico approaches are currently not employed in any of the spices to study the toxicity. The aim of this study is to find the most efficacious molecule which does not have any adverse effects. In the present study one hundred and eight compounds from cardamom were used to predict mutagenicity and carcinogenecity. The results of these studies indicate that only four compounds are non-mutagenic and non-carcinogenic. The rest of the compounds do not have the characteristics necessary to become therapeutic agents have been identified early and prevented (i.e., the fail early, fail fast approach) from entering the drug development process

    Utility of nucleated RBCs in critical care patients in a tertiary care centre

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    Background: In healthy adults and older children, NRBCs are normally found only in the blood-building bone marrow where they mature. Their appearance in peripheral blood points to extramedullary erythropoiesis or disruption of the blood-bone marrow barrier. Aim of current study was to evaluate and compare the prognostic significance of NRBCs in the peripheral blood of intensive care patients (ICU) and non-intensive care patients (non-ICI) and to assess the morbidity and mortality risk associated with NRBCs among ICU and non-ICU patients. Methods: Relevant clinical details and investigations were collected from the Haematology nominal Register of the Department of Pathology, Saveetha Medical College. Blood samples were routinely drawn in the morning. The presence of NRBCs in the peripheral blood was detected with the help of an automated analyser (Sysmex XN 1000) and confirmed by a peripheral smear. Results: Among the NRBC-positive study population, mortality rate was 28% and was associated with ICU admission status, and death was predominantly due to cardiovascular causes. The highest NRBC value during the period of admission was significantly associated with deceased patients and ICU patients (p values of <0.001 and 0.002 respectively). The Pearson correlation of NRBC shows a significant positive correlation with serum creatinine and a negative correlation with platelets. Conclusions: The presence of NRBCs in the peripheral blood of critically ill adults is a significant prognostic marker of morbidity and mortality, laying down the emphasis on daily screening of peripheral smears for NRBCs

    An Integrative Review of Web 3.0 in Academic Libraries

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    Purpose – The aim of this paper is to present an integrated literature review exploring the nature of responsive, semantic and interactive Web 3.0 technologies applicable for academic libraries. Design/methodology/approach – We conducted an integrated review of the literature combining a strategy of automated and keywords search. The main source for identifying the studies are Emerald Library Studies and Information & Knowledge Management eJournals, Web of Knowledge, and Library, Information Science & Technology Abstracts (EBSCO) databases. To this end, a sample of (n= 140) studies were analyzed to characterize the Web 3.0 trends and its applications based on theme, years and document types. Findings – A review of literature reveals that Web 3. needs evaluation as to what extent they are integrated, deployed and mainstreamed into library services and in information management practices. It is important to develop a conceptual framework that explores the linkages of Web 3.0 technologies and their applications in academic libraries. Originality/value –This review shows how Web 3.0 technologies enhance library services in its holistic conceptualization and how academic libraries are moving into a more robust, inclusive and adaptable phase in their service values and innovation

    A Policy Review of Public Libraries in India

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    Purpose The purpose of this paper is to analyze the status of policies, legislation and finance with respect to public libraries in India. Design/methodology/approach This is a descriptive study based on data collected from literature review and census data on public libraries, along with a field visit of government public libraries at Bangalore. It attempts a critique of existing policies related to public libraries in particular and the culture sector in general, which governs the Galleries, Libraries, Archives and Museums (GLAMs) in India. Findings Of India’s 29 states and 7 union territories, 19 states have passed state library legislations, of which only 5 have the provision of a library cess or tax levy and it was found that states with lower literacy rates do not have library legislations. Bihar and Chhattisgarh in 2008 and Arunachal Pradesh in 2009 have recently passed these legislations without a library cess. Few states have progressed with the automation of public libraries, while 16 state libraries continue to function without any such legislation. The legislative process and legal issues involved in policy making, combined with the lack of political consensus and goodwill, have severely constrained the growth, coverage and development of public libraries for people in India. The existing national acts and state library legislations should be reviewed to adapt to changing times and to bring about integrated information services across GLAMs for the public. A RTI query sent to the Ministry of Culture revealed that there is no official data available on the per capita expenditure on public libraries in India. Practical implications In an online-networked environment, all GLAM institutions work towards collecting, preserving and providing access to educational and cultural heritage resources as social capital. However, there is a lack of national policy to govern GLAMs and the government bodies responsible for developing GLAMs are not integrative in their processes. A more holistic framework is required to assess funding needs and to ensure reforms in culture sector. Central government should make it mandatory to have access to public library for every citizen of India, legitimating public library services, even as India celebrates 100 years of public librarianship and enters its second century of providing library and information services to the nation. Originality/value GLAMs should be inclusionary public spaces for intellectual engagement and community development and need greater attention of policy makers. Though the public library movement reached its peak in the nationalist movements of the early 20th century, developing integrated and contemporary policies for the growth and development of public libraries as a public good in the 21st century will make India a knowledge society
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