54,513 research outputs found

    Accidents to Farm People. 29,361 Reasons for a Safety Program

    Get PDF
    PDF pages:

    Thermal control for mobile packages in the dusty lunar environment

    Get PDF
    Dual surface configurations illustrating thermal protection concepts to improve performance of simple radiative surfaces in mobile, dusty, lunar environment

    Experimental investigation of the mixing of two parallel streams of dissimilar fluids

    Get PDF
    Velocity and density profiles in mixing region between adjacent half jets of dissimilar fluid

    Analytical investigation of the mixing of two parallel streams of dissimilar fluids

    Get PDF
    Free jet mixing analysis for parallel streams of different fluid

    Suggestions and Instructions for Using the Ohio Commercial Farm Account System

    Get PDF
    PDF pages: 1

    Cephem Potentiation by Inactivation of Nonessential Genes Involved in Cell Wall Biogenesis of ß-Lactamase-Producing Escherichia coli

    Get PDF
    Reversal of antimicrobial resistance is an appealing and largely unexplored strategy in drug discovery. The objective of this study was to identify potential targets for “helper” drugs reversing cephem resistance in Escherichia coli strains producing β-lactamases. A CMY-2-encoding plasmid was transferred by conjugation to seven isogenic deletion mutants exhibiting cephem hypersusceptibility. The effect of each mutation was evaluated by comparing the MICs in the wild type and the mutant harboring the same plasmid. Mutation of two genes encoding proteins involved in cell wall biosynthesis, dapF and mrcB, restored susceptibility to cefoxitin (FOX) and reduced the MICs of cefotaxime and ceftazidime, respectively, from the resistant to the intermediate category according to clinical breakpoints. The same mutants harboring a CTX-M-1-encoding plasmid fell into the intermediate or susceptible category for all three drugs. Individual deletion of dapF and mrcB in a clinical isolate of CTX-M-15-producing E. coli sequence type 131 (ST131) resulted in partial reversal of ceftazidime and cefepime resistance but did not reduce MICs below susceptibility breakpoints. Growth curve analysis indicated no fitness cost in a ΔmrcB mutant, whereas a ΔdapF mutant had a 3-fold longer lag phase than the wild type, suggesting that drugs targeting DapF may display antimicrobial activity, in addition to synergizing with selected cephems. DapF appeared to be a potential FOX helper drug target candidate, since dapF inactivation resulted in synergistic potentiation of FOX in the genetic backgrounds tested. The study showed that individual inactivation of two nonessential genes involved in cell wall biogenesis potentiates cephem activity according to drug- and strain-specific patterns

    Research in the development of an improved multiplier phototube

    Get PDF
    Performance and response characteristics of smoothing, image intensifier dissector for low light level astronomy and optical detectio

    Stability of shear flow with density gradient and viscosity

    Get PDF
    Stability of shear flow with density gradient and viscosit

    Research related to measurements of atomic species in the earth's upper atmosphere Final report

    Get PDF
    Interaction kinetics of atomic oxygen and hydrogen on metal surfaces of satellite-borne mass spectrometer
    corecore