Analisis Swot Pada Credit Union Mura Kopa Di Balai Karangan

This study aims to observe the strength, weaknesses, opportunities, and threats that theCredit Union (CU) of Mura Kopa of Balai Karangan faces. All these essential elements willhelp the CU to take a right decision, to set up an operational strategy, and to reach anobjective goal in the future. This descriptive study collected data by means of observation,interviews, and document study. Data processing was done by scoring the elements ofopportunities, threats, strength, and weaknesses. All these components were analyzed bySWOT Matrix in order to find out rational strategies that can be categorized into fourperspectives, i.e., financial, client or member satisfaction, internal business process, andlearning and growth perspectives. The result of this research is that CU of Mura Kopa'strength can make the profit of the good opportunities, but a series of weaknesses andthreats need to be overcome. All board, superintendent, and managers need to apply astrategy that supports the policy of growth oriented by taking some initiatives of strategicaction

Pengaruh Pembelajaran Berbasis Komputer terhadap Kreativitas Belajar Siswa pada Mata Pelajaran Tik Siswa Kelas IX di SMPN 2 Kayangan

Minimnya model atau metode pembelajaran yang diterapkan didalam kelas sehingga proses pembelajaran monoton pada cara-cara lama, sehingga pengembangan kreativitas belajar siswa sangat minim. Rumusan masalah penelitian ini “apakah ada pengaruh penggunaan Pembelajaran Berbasis Komputer terhadap kreativitas belajar siswa pada mata pelajaran TIK siswa kelas IX di SMP Negeri 2 Kayangan Kabupaten Lombok Utara”.Tujuan Penelitian ini “ingin mengetahui pengaruh Pembelajaran Berbasis Komputer terhadap kreativitas belajar siswa pada mata pelajaran TIK siswa kelas IX di SMP Negeri 2 Kayangan Kabupaten Lombok Utara Tahun Pelajaran 2016/2017”.Rancangan penelitian yang digunakan peneliti adalah Post Experimen-Control Design. JumlahPopulasi 48 orang.Dengan teknik pengambilan sampel random sampling.Adapun sampel yang digunakan adalah kelas IX.1 yakni kelas eksperimen yang diberikan perlakuan dan kelas IX.2 merupakan kelas kontrol sebagai kelas pembanding.Untuk memperoleh data dalam penelitian ini, maka digunakan metode angket sebagai metode utama dan metode dokumentasi merupakan metode pendukung.Teknik analisis data menggunakan t-test. Berdasarkan hasil perhitungan, diketahui nilai “t” diperoleh sebesar6,596 Selanjutnya nilai tersebut yang dikonsultasikan pada taraf signifikansi 5% dengan N = 24 ternyata batas angka penerimaan atau penolakan hipotesis nol (H0) yang diajukan pada table distribusi t adalah sebesar 2,069. Kenyataan ini menunjukkan nilai thitunglebih besar dari angka penolakan hipotesis nol (H0) antara nilai thitung sebesar 6,596 lebih besar dari ttabelsebesar 2,069 (thitung 6,596 > ttabel 2,069). Maka dapat disimpulkan bahwa H0 di tolak sedangkan Ha diterima. Dengan demikian hipotesis (Ha) berbunyi: Ada Pengaruh Pembelajaran Berbasis Komputer Terhadap Kreativitas Belajar Siswa Pada Mata Pelajaran TIK Siswa Kelas IX di SMP Negeri 2 Kayangan Kabupaten Lombok Utara Tahun Pelajaran 2016/2017 diterima

Mechanisms of Diabetes-Induced Liver Damage : The role of oxidative stress and inflammation (

Diabetes mellitus is a non-communicable disease that occurs in both developed and developing countries. This metabolic disease affects all systems in the body, including the liver. Hyperglycaemia, mainly caused by insulin resistance, affects the metabolism of lipids, carbohydrates and proteins and can lead to nonalcoholic fatty liver disease, which can further progress to non-alcoholic steatohepatitis, cirrhosis and, finally, hepatocellular carcinomas. The underlying mechanism of diabetes that contributes to liver damage is the combination of increased oxidative stress and an aberrant inflammatory response; this activates the transcription of pro-apoptotic genes and damages hepatocytes. Significant involvement of pro-inflammatory cytokines—including interleukin (IL)-1β, IL-6 and tumour necrosis factor-α—exacerbates the accumulation of oxidative damage products in the liver, such as malondialdehyde, fluorescent pigments and conjugated dienes. This review summarises the biochemical, histological and macromolecular changes that contribute to oxidative liver damage among diabetic individuals

Tocotrienol-Rich Fraction from Palm Oil Prevents Oxidative Damage in Diabetic Rats

Objectives: This study was carried out to determine the effects of tocotrienol-rich fraction (TRF) (200 mg/Kg) on biomarkers of oxidative stress on erythrocyte membranes and leukocyte deoxyribonucleic acid (DNA) damage in streptozotocin (STZ)-induced diabetic rats. Methods: Male rats (n = 40) were divided randomly into four groups of 10: a normal group; a normal group with TRF; a diabetic group, and a diabetic group with TRF. Following four weeks of treatment, fasting blood glucose (FBG) levels, oxidative stress markers and the antioxidant status of the erythrocytes were measured. Results: FBG levels for the STZ-induced diabetic rats were significantly increased (P <0.001) when compared to the normal group and erythrocyte malondialdehyde levels were also significantly higher (P <0.0001) in this group. Decreased levels of reduced glutathione and increased levels of oxidised glutathione (P <0.001) were observed in STZ-induced diabetic rats when compared to the control group and diabetic group with TRF. The results of the superoxide dismutase and glutathione peroxidase activities were significantly lower in the STZ-induced diabetic rats than in the normal group (P <0.001). The levels of DNA damage, measured by the tail length and tail moment of the leukocyte, were significantly higher in STZ-induced diabetic (P <0.0001). TRF supplementation managed to normalise the level of DNA damage in diabetic rats treated with TRF. Conclusion: Daily supplementation with 200 mg/Kg of TRF for four weeks was found to reduce levels of oxidative stress markers by inhibiting lipid peroxidation and increasing the levels of antioxidant status in a prevention trial for STZ-induced diabetic rats

Incorporating 3-dimensional models in online articles

Introduction The aims of this article are to introduce the capability to view and interact with 3-dimensional (3D) surface models in online publications, and to describe how to prepare surface models for such online 3D visualizations. Methods Three-dimensional image analysis methods include image acquisition, construction of surface models, registration in a common coordinate system, visualization of overlays, and quantification of changes. Cone-beam computed tomography scans were acquired as volumetric images that can be visualized as 3D projected images or used to construct polygonal meshes or surfaces of specific anatomic structures of interest. The anatomic structures of interest in the scans can be labeled with color (3D volumetric label maps), and then the scans are registered in a common coordinate system using a target region as the reference. The registered 3D volumetric label maps can be saved in.obj,.ply,.stl, or.vtk file formats and used for overlays, quantification of differences in each of the 3 planes of space, or color-coded graphic displays of 3D surface distances. Results All registered 3D surface models in this study were saved in.vtk file format and loaded in the Elsevier 3D viewer. In this study, we describe possible ways to visualize the surface models constructed from cone-beam computed tomography images using 2D and 3D figures. The 3D surface models are available in the article's online version for viewing and downloading using the reader's software of choice. These 3D graphic displays are represented in the print version as 2D snapshots. Overlays and color-coded distance maps can be displayed using the reader's software of choice, allowing graphic assessment of the location and direction of changes or morphologic differences relative to the structure of reference. The interpretation of 3D overlays and quantitative color-coded maps requires basic knowledge of 3D image analysis. Conclusions When submitting manuscripts, authors can now upload 3D models that will allow readers to interact with or download them. Such interaction with 3D models in online articles now will give readers and authors better understanding and visualization of the results

The UNC-Wisconsin rhesus macaque neurodevelopment database: A structural MRI and DTI database of early postnatal development

Rhesus macaques are commonly used as a translational animal model in neuroimaging and neurodevelopmental research. In this report, we present longitudinal data from both structural and diffusion MRI images generated on a cohort of 34 typically developing monkeys from 2 weeks to 36 months of age. All images have been manually skull stripped and are being made freely available via an online repository for use by the research community

Diagnostic index: An open-source tool to classify TMJ OA condyles

Osteoarthritis (OA) of temporomandibular joints (TMJ) occurs in about 40% of the patients who present TMJ disorders. Despite its prevalence, OA diagnosis and treatment remain controversial since there are no clear symptoms of the disease, especially in early stages. Quantitative tools based on 3D imaging of the TMJ condyle have the potential to help characterize TMJ OA changes. The goals of the tools proposed in this study are to ultimately develop robust imaging markers for diagnosis and assessment of treatment efficacy. This work proposes to identify differences among asymptomatic controls and different clinical phenotypes of TMJ OA by means of Statistical Shape Modeling (SSM), obtained via clinical expert consensus. From three different grouping schemes (with 3, 5 and 7 groups), our best results reveal that that the majority (74.5%) of the classifications occur in agreement with the groups assigned by consensus between our clinical experts. Our findings suggest the existence of different disease-based phenotypic morphologies in TMJ OA. Our preliminary findings with statistical shape modeling based biomarkers may provide a quantitative staging of the disease. The methodology used in this study is included in an open source image analysis toolbox, to ensure reproducibility and appropriate distribution and dissemination of the solution proposed

Fixatives increase the efficacy of gel formulations containing Piper aduncum linnaeus (Piperales: Piperaceae) essential oil as repellenty

Piper aduncum essential oil exhibit repellency activity and has a potential to be use as an alternative for synthetic repellent such as N,N-diethyl-3- methylbenzamide, (DEET). However, the volatility properties of the essential oil decrease their persistence as a topical repellent. Study has shown that formulation of the essential oil with some fixatives may increase their effectiveness. Therefore, this study was conduct to evaluate the effectiveness of gel formulation containing P. aduncum essential oil with two fixative; vanillin and paraffin oil. Gel formulations containing P. aduncum essential oil with 5% and 10% vanillin and 6% paraffin oil was prepared and tested against Aedes aegypti in laboratory using Standards and Industrial Research Institute of Malaysia (SIRIM) bioassay method. After 240 minute post-application, formulation containing 5% and 10% vanillin was able to provide >70% repellency percentage against mosquito while formulation containing 6% paraffin oil gives <30% repellency percentage. As conclusion, P. aduncum based repellent gel containing 5% and 10% vanillin was able to prolong the effect of P. aduncum essential oil as repellent against dengue vector in laboratory

The challenges of the expanded availability of genomic information: an agenda-setting paper

Rapid advances in microarray and sequencing technologies are making genotyping and genome sequencing more affordable and readily available. There is an expectation that genomic sequencing technologies improve personalized diagnosis and personalized drug therapy. Concurrently, provision of direct-to-consumer genetic testing by commercial providers has enabled individuals’ direct access to their genomic data. The expanded availability of genomic data is perceived as influencing the relationship between the various parties involved including healthcare professionals, researchers, patients, individuals, families, industry, and government. This results in a need to revisit their roles and responsibilities. In a 1-day agenda-setting meeting organized by the COST Action IS1303 “Citizen’s Health through public-private Initiatives: Public health, Market and Ethical perspectives,” participants discussed the main challenges associated with the expanded availability of genomic information, with a specific focus on public-private partnerships, and provided an outline from which to discuss in detail the identified challenges. This paper summarizes the points raised at this meeting in five main parts and highlights the key cross-cutting themes. In light of the increasing availability of genomic information, it is expected that this paper will provide timely direction for future research and policy making in this area.Funding Deborah Mascalzoni is supported under Grant Agreement number 305444. Álvaro Mendes is supported by the FCT—The Portuguese Foundation for Science and Technology under postdoctoral grant SFRH/BPD/88647/2012. Isabelle Budin-Ljøsne receives support from the National Research and Innovation Platform for Personalized Cancer Medicine funded by The Research Council of Norway (NFR BIOTEK2021/ES495029) and Biobank Norway funded by The Research Council of Norway—grant number 245464. Heidi Carmen Howard is partly supported by supported by the Swedish Foundation for Humanities and Social Science under grant M13-0260:1), the Biobanking and Molecular Resource Infrastructure of Sweden (BBMRI.se) and the BBMRI-ERIC. Brígida Riso is supported by the Portuguese Foundation for Science and Technology (FCT) under the PhD grant SFRH/BD/100779/2014. Heidi Beate Bentzen receives support from the project Legal Regulation of Information Processing relating to Personalized Cancer Medicine funded by The Research Council of Norway BIOTEK2021/238999