5,081 research outputs found
Hydrodynamic and rheology of active polar filaments
The cytoskeleton provides eukaryotic cells with mechanical support and helps
them perform their biological functions. It is a network of semiflexible polar
protein filaments and many accessory proteins that bind to these filaments,
regulate their assembly, link them to organelles and continuously remodel the
network. Here we review recent theoretical work that aims to describe the
cytoskeleton as a polar continuum driven out of equilibrium by internal
chemical reactions. This work uses methods from soft condensed matter physics
and has led to the formulation of a general framework for the description of
the structure and rheology of active suspension of polar filaments and
molecular motors.Comment: 30 pages, 5 figures. To appear in "Cell Motility", Peter Lenz, ed.
(Springer, New York, 2007
Organization and instabilities of entangled active polar filaments
We study the dynamics of an entangled, isotropic solution of polar filaments
coupled by molecular motors which generate relative motion of the filaments in
two and three dimensions. We investigate the stability of the homogeneous state
for constant motor concentration taking into account excluded volume and
entanglement. At low filament density the system develops a density
instability, while at high filament density entanglement effects drive the
instability of orientational fluctuations.Comment: 4pages, 2 eps figure, revtex
Downregulation of major histocompatibility complex class I in bovine papillomas
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy. Even in the absence of malignant transformation, BPV infection persists for a significant period of time before activation of the host immune system, suggesting that the host immune system is unaware of, or disabled by, BPV. E5 is the major oncoprotein of BPV, which, in addition to its transforming properties, downregulates the expression and transport to the cell surface of major histocompatibility complex class I (MHC I). Here, it is shown that co-expression of MHC I and E5 in papillomas caused by BPV-4 infection is mutually exclusive, in agreement with the inhibition of surface MHC I expression by E5 that is observed in vitro. The inhibition of MHC expression in E5-expressing papilloma cells could explain the long period that is required for activation of the immune response and has implications for the progression of papillomas to the malignant stage; absence of peptide presentation by MHC I to cytotoxic T lymphocytes would allow the infected cells to evade the host cellular immune response and allow the lesions to persist
Complex Spontaneous Flows and Concentration Banding in Active Polar Films
We study the dynamical properties of active polar liquid crystalline films.
Like active nematic films, active polar films undergo a dynamical transitions
to spontaneously flowing steady-states. Spontaneous flow in polar fluids is,
however, always accompanied by strong concentration inhomogeneities or
"banding" not seen in nematics. In addition, a spectacular property unique to
polar active films is their ability to generate spontaneously oscillating and
banded flows even at low activity. The oscillatory flows become increasingly
complicated for strong polarity.Comment: 4 pages, 3 figure
Sheared active fluids: thickening, thinning and vanishing viscosity
We analyze the behavior of a suspension of active polar particles under
shear. In the absence of external forces, orientationally ordered active
particles are known to exhibit a transition to a state of non-uniform
polarization and spontaneous flow. Such a transition results from the interplay
between elastic stresses, due to the liquid crystallinity of the suspension,
and internal active stresses. In the presence of an external shear we find an
extremely rich variety of phenomena, including an effective reduction
(increase) in the apparent viscosity depending on the nature of the active
stresses and the flow-alignment property of the particles, as well as more
exotic behaviors such as a non-monotonic stress/strain-rate relation and yield
stress for large activities.Comment: 10 pages, 10 figure
Spontaneous thought and vulnerability to mood disorders : the dark side of the wandering mind
There is increasing interest in spontaneous thought, namely task-unrelated or rest-related mental activity. Spontaneous thought is an umbrella term for processes like mind-wandering, involuntary autobiographical memory, and daydreaming, with evidence elucidating adaptive and maladaptive consequences. In this theoretical framework, we propose that, apart from its positive functions, spontaneous thought is a precursor for cognitive vulnerability in individuals who are at risk for mood disorders. It is important that spontaneous thought mostly focuses on unattained goals and evaluates the discrepancy between current and desired status. In individuals who stably (i.e., trait negative affectivity) or transitorily (i.e., stress) experience negative emotions in reaction to goal-discrepancy, spontaneous thought fosters major cognitive vulnerabilities (e.g., rumination, hopelessness, low self-esteem, and cognitive reactivity), which, in turn, enhance depression. Furthermore, we also highlight preliminary links between spontaneous thought and bipolar disorder. The evidence for this framework is reviewed, and we discuss theoretical and clinical implications of our proposal
Transport Properties in the "Strange Metal Phase" of High Tc Cuprates: Spin-Charge Gauge Theory Versus Experiments
The SU(2)xU(1) Chern-Simons spin-charge gauge approach developed earlier to
describe the transport properties of the cuprate superconductors in the
``pseudogap'' regime, in particular, the metal-insulator crossover of the
in-plane resistivity, is generalized to the ``strange metal'' phase at higher
temperature/doping. The short-range antiferromagnetic order and the gauge field
fluctuations, which were the key ingredients in the theory for the pseudogap
phase, also play an important role in the present case. The main difference
between these two phases is caused by the existence of an underlying
statistical -flux lattice for charge carriers in the former case, whereas
the background flux is absent in the latter case. The Fermi surface then
changes from small ``arcs'' in the pseudogap to a rather large closed line in
the strange metal phase. As a consequence the celebrated linear in T dependence
of the in-plane and out-of-plane resistivity is shown explicitly to recover.
The doping concentration and temperature dependence of theoretically calculated
in-plane and out-of-plane resistivity, spin-relaxation rate and AC conductivity
are compared with experimental data, showing good agreement.Comment: 14 pages, 5 .eps figures, submitted to Phys. Rev. B, revised version
submitted on 24 Oc
Fractional exclusion and braid statistics in one dimension: a study via dimensional reduction of Chern-Simons theory
The relation between braid and exclusion statistics is examined in
one-dimensional systems, within the framework of Chern-Simons statistical
transmutation in gauge invariant form with an appropriate dimensional
reduction. If the matter action is anomalous, as for chiral fermions, a
relation between braid and exclusion statistics can be established explicitly
for both mutual and nonmutual cases. However, if it is not anomalous, the
exclusion statistics of emergent low energy excitations is not necessarily
connected to the braid statistics of the physical charged fields of the system.
Finally, we also discuss the bosonization of one-dimensional anyonic systems
through T-duality.Comment: 19 pages, fix typo
Absorption, Photoluminescence and Resonant Rayleigh Scattering Probes of Condensed Microcavity Polaritons
We investigate and compare different optical probes of a condensed state of
microcavity polaritons in expected experimental conditions of non-resonant
pumping. We show that the energy- and momentum-resolved resonant Rayleigh
signal provide a distinctive probe of condensation as compared to, e.g.,
photoluminescence emission. In particular, the presence of a collective sound
mode both above and below the chemical potential can be observed, as well as
features directly related to the density of states of particle-hole like
excitations. Both resonant Rayleigh response and the absorption and
photoluminescence, are affected by the presence of quantum well disorder, which
introduces a distribution of oscillator strengths between quantum well excitons
at a given energy and cavity photons at a given momentum. As we show, this
distribution makes it important that in the condensed regime, scattering by
disorder is taken into account to all orders. We show that, in the low density
linear limit, this approach correctly describes inhomogeneous broadening of
polaritons. In addition, in this limit, we extract a linear blue-shift of the
lower polariton versus density, with a coefficient determined by temperature
and by a characteristic disorder length.Comment: 16 pages, 11 figures; minor correction
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