A measurement of the \u3ci\u3eWγ\u3c/i\u3e cross section at √S = 8 TEV in \u3ci\u3ePP\u3c/i\u3e collisions with the CMS detector

A measurement of cross section of the Wγ → lνγ production in proton-proton collisions using 19.6 fb − 1 of LHC data collected by CMS detector at the center- √ of-mass collision energy of s = 8 TeV is reported. The W bosons are identified in their electron and muon decay modes. The process of Wγ production in the Standard Model (SM) involves a pure gauge boson coupling, a WWγ vertex, which allows one to test the electroweak sector of the SM in a unique way not achievable by studies of other processes. In addition to the total cross section, we measure the differential cross section of Wγ production as a function of a photon transverse momentum. The measurement of the differential cross section is a sensitive probe for new physics originating from an anomalous gauge coupling because possible effects of its presence increase with the photon transverse momentum and, thus, are more likely to be observed in the differential than in the total cross section. The results of this measurement agree with the Standard Model prediction at NLO in QCD, and no evidence of an anomalous triple gauge coupling has been observed. The reported total cross section measurement is the first measurement of this quantity at the 8 TeV collision energy with CMS data. The differential cross section measurement discussed in this dissertation is the first ever measurement of this process performed by CMS since the start of the LHC. Adviser: Ilya Kravchenk

Управление энергосбережением промышленного предприятия: сущность и организационно-экономические инструменты

Innovative and effective energy sector creation is a key point for international companies in time of resource globalization. Energy efficiency police is an issue of resource-saving. The target of this article is to work out the methods of energy efficiency increase during all energy production and consumption steps (as an example, international company)

Advantages of Nanosensors in the Development of Interfaces for Bioelectric Prostheses

The present research aims to explore the bioelectric activity of muscles using a high-resolution electromyograph and to analyze the prospects of the electromyograph to develop bioelectric patterns for the prosthesis control method based on the data recognition system. The activity of the healthy forearm muscles was investigated during the cyclic activity of fingers in different modes. In addition, the impact of filters on the quality and informativity of myoelectric signals, as well as on the development of bioelectric activity patterns was analyzed. The virtually developed bandpass filters were utilized as experimental filters. The filter impact analysis included the comparison of the signal recorded in the frequency band from 0 to 10000 Hz with the signal filtered in the frequency band from 20 to 500 Hz. The research revealed the advantages of a high-resolution electromyogram for the pattern recognition-based myocontrol

Advantages of Nanosensors in the Development of Interfaces for Bioelectric Prostheses

The present research aims to explore the bioelectric activity of muscles using a high-resolution electromyograph and to analyze the prospects of the electromyograph to develop bioelectric patterns for the prosthesis control method based on the data recognition system. The activity of the healthy forearm muscles was investigated during the cyclic activity of fingers in different modes. In addition, the impact of filters on the quality and informativity of myoelectric signals, as well as on the development of bioelectric activity patterns was analyzed. The virtually developed bandpass filters were utilized as experimental filters. The filter impact analysis included the comparison of the signal recorded in the frequency band from 0 to 10000 Hz with the signal filtered in the frequency band from 20 to 500 Hz. The research revealed the advantages of a high-resolution electromyogram for the pattern recognition-based myocontrol

Management of Energy Saving 0f the Industrial Enterprise: Essence and Organizational and Economic Tools

Innovative and effective energy sector creation is a key point for international companies in time of resource globalization. Energy efficiency police is anissue of resource-saving . The target of this article is to work out the methods of energy efficiency increase during all energy production and consumption steps (as an example, international company)

Results of a double-blind, randomized, comparative, cross-sectional study of the pharmacokinetics and pharmacodynamics of genetically engineered human insulin preparations

Justification. On average, about 12 % of all global healthcare spending on diabetes. One of the first domestic human insulin preparations was Rinsulin® R, the biosimilar (bioanalog) of Humulin® Regular. The clinical research program for biosimilars of insulin preparations includes pharmacology studies: pharmacokinetics, pharmacodynamics and clinical safety research. Purpose. Evaluation of the biosimilarity of the Rinsulin® R (biosimilar) and Humulin® Regular (original) preparations in the conditions of hyperinsulinemic euglycemic clamp in healthy volunteers. Materials and methods. The study was conducted on healthy male volunteers aged 18 to 50 years. Study design is a double-blind, randomized, cross-sectional study of comparative pharmacokinetics and pharmacodynamics of drugs. The drugs were injected subcutaneously into the anterior abdominal wall at a dose of 0.3 IU / kg once. The duration of blood sampling to determine the pharmacokinetic parameters was 10 hours: the concentration of insulin in the blood was determined by enzyme-linked immunosorbent assay. Based on the level of glycemia, the glucose infusion rate was adjusted, the data of which were used to calculate the pharmacodynamic parameters. Results and discussion. It was found that the studied drugs are characterized by a high degree of similarity of pharmacokinetics and pharmacodynamics. 90 % confidence intervals for the ratios of the geometric mean values of the primary pharmacokinetics AUCins.0-t and Cins.max fully correspond to the permissible limits of 80-125 % and are, respectively, 88.61-111.52 and 85.411-109,51 %. 95 % confidence intervals for the ratios of the geometric mean values of the primary pharmacodynamics AUCGIR0-t and GIRmax fully correspond to the permissible limits of 80-125 % and are, respectively, 93.48-112.29 and 95.75-109.17 %. Of particular clinical significance are the synchronous onset of action of drugs, the time of onset of the maximum effect and duration of action. The frequency of adverse events was comparable in the drug groups. Conclusions. Rinsulin® R and Humulin® Regular are equivalent

Assessment the equivalence of the bioanalogue insulin lizpro biphasic 25 (Geropharm-bio, Russia) and Humalog® Mix 25 (Lilly France, France) using the euglycemic hyperinsulinum clamp method on healthy volonters

Background: Modern medicine requires use of effective antidiabetic drugs that can imitate the natural profile of insulin in the body of patients with diabetes mellitus. Examples of such preparations include biphasic insulin lispro, which is a mixture of insulin lispro ultra-short action and insulin lispro protamine suspension with prolonged effect. The clinical trials (CT) program for biosimilar insulins contains pharmacology studies: pharmacokinetics (PK), pharmacodynamics (PD) and clinical safety studies. Aims: To demonstrate Biphasic Insulin Lispro 25, suspension for subcutaneous administration, 100 U/ml (GEROPHARM-Bio, Russia) and Humalog® Mix 25, suspension for subcutaneous administration, 100 U/ml (Lilly France, France) have comparable pharmacokinetic profiles under conditions of hyperinsulinemic euglycemic clamp (HEC) in healthy volunteers. Materials and methods: The study was conducted on 48 healthy men aged between 18 to 50 years. This was a double-blind, randomized, crossover study of comparative pharmacokinetics of drugs. The investigational products (IP) were administered before the clamp in a single dose of 0.4 U/kg subcutaneously in the abdominal wall. Regular blood sampling was performed during the study. The insulin concentrations in the samples were determined using an ELISA method. The results of the determination were used to calculate the PK parameters and construct the concentration-time curves. Adjust glucose infusion rates were based on blood glucose measurements. These data were used to calculate the PD parameters. Results: Our results demonstrated that Biphasic Insulin Lispro 25 and Humalog® Mix 25 have comparable PK and PD profiles under conditions of HEC in healthy volunteers. The confidence intervals for the ratio of the geometric mean for Cins.max and AUCins.0–12 were 87.75–99.90% and 83.76–96.98% respectively, which were well within 80–125% limits for establishing comparability. Conclusions: Biphasic Insulin Lispro 25 and Humalog® Mix 25 are equivalent based on this CT applying the HEC technique in healthy volunteers

The «cut-off point» of vitamin D: a method of suppressing excessive secretion of PTH

BACKGROUND: The subject of discussion is the issue of the separation point, which determines sufficient levels of vitamin D for bone health. When determining the adequate reference range of vitamin D, researchers are mainly guided by the results of research, where the level of 25(OH)D is determined, at which the PTH level decreases and reaches a plateau. AIM: To establish the «cut-off point» of vitamin D by suppressing excessive secretion of PTH. MATERIALS AND METHODS: Observational, single-site, single-stage, selective, uncontrolled study of the search for vitamin D levels by the effect on PTH secretion in residents of Tyumen region was conducted (n = 176). All selected study participants determined the level of 25(OH)D and PTH in serum. The calculation of the «cut-off point» was carried out using the method of searching for changes in the correlation dependence of PTH on the level of vitamin D, followed by verification of the data obtained using ROC analysis. RESULTS: A mathematical analysis of the dependence of 25(OH)D and PTH showed the “cut-off point” of vitamin D, equal to – 23.6 ng/ml. CONCLUSION: The “cut-off point” of 23.6 ng/ml is optimal for suppressing excessive PTH secretion. The data obtained may be an incentive for further working out the “cut-off point” of vitamin D for the Russian population and can be used to clarify the classification of deficiency, insufficiency and optimal levels of vitamin D for the population of the Russian Federation

Biosimilar of biphasic human insulin: results of a double-blind, randomized, comparative, cross-sectional clinical study of pharmacokinetics

Justification. The prevalence of type 2 diabetes is extremely high, and the number of such patients is constantly increasing. In 30-40% of patients, only insulin therapy can achieve compensation for the disease. Therapy with ready-made mixtures is considered as an alternative option in the initiation and intensification of insulin therapy. Rinsulin® mix 30/70 is a domestic biosimilar (bioanalogue) of Humulin® M3, a combination of a 30% solution of human insulin and a 70% suspension of insulin-isofan. The clinical research program for biosimilars of insulin preparations includes pharmacology studies: pharmacokinetics, pharmacodynamics and clinical safety research. Purpose. Evaluation of the biosimilarity of Rinsulin® mix 30/70 (bioanalog) and Humulin® M3 (original) preparations in the conditions of hyperinsulinemic euglycemic clamp in healthy volunteers. Materials and methods. The study was conducted on healthy male volunteers aged 18 to 50 years. Study design is a double-blind, randomized, crossover study of the comparative pharmacokinetics of drugs. The drugs were injected subcutaneously into the anterior abdominal wall at a dose of 0.4 IU / kg once. The duration of blood sampling to determine the pharmacokinetic parameters was 24 hours: the concentration of insulin in the blood was determined by enzyme-linked immunosorbent assay. Based on the level of glycemia, the glucose infusion rate was adjusted, the data of which were used to calculate the pharmacodynamic parameters. Results and discussion. Comparability of the main pharmacokinetic and pharmacodynamic characteristics of the Rinsulin® mix 30/70 and Humulin® M3 preparations in the conditions of hyperinsulinemic euglycemic clamp in healthy volunteers was noted. The confidence interval for the logarithmically transformed ratio of the values of the parameter Cins.max was 87.31-105.26%, and AuCins.0-12 - 85.23-110.90%, which falls within the limits set by regulatory documents 80-125% to establish comparability between drugs. This confirms the high similarity of the reproduced Rinsulin® Mix 30/70 to the original drug. Of particular clinical significance is the synchronous onset of drug action, the time of onset of the maximum effect and duration of action. Adverse events in the study associated with the introduction of drugs were not recorded. Conclusions. Rinsulin® mix 30/70 and Humulin® M3 are equivalent

Search for charge-asymmetric production of W\u27 bosons in tt + jet events from pp collisions at √s = 7 TeV

A search is presented for charge-asymmetric production of a W\u27 boson that has been proposed to accommodate the forward–backward asymmetry observed in the production of top–antitop quark pairs at the Tevatron. The new heavy W\u27 boson would be produced in association with a top quark and would decay into top and down quarks. The data correspond to an integrated luminosity of 5.0 fb−1 in pp collisions at a center-of-mass energy of 7 TeV, recorded by the CMS detector at the LHC. No significant excess above the standard model expectations is observed, and, from a combination of the electron-plusjets and muon-plus-jets channels, a 95% confidence level lower limit of 840 GeV/c2 is set on the W\u27 boson mass for a W\u27 boson model with values for coupling constants to top and down quarks gL = 0 and gR = 2. In addition, a kinematic reconstruction of the W[1] resonance mass using the inherent charge asymmetry of this model finds no indication of the presence of W\u27 events in the data