Characterization of HTP-LAMP positive blood samples (N = 22).

<p>Characterization of HTP-LAMP positive blood samples (N = 22).</p

Diagnostic accuracy of Malaria pan HTP-LAMP compared to PCR for 3008 field samples.

<p>Diagnostic accuracy of Malaria pan HTP-LAMP compared to PCR for 3008 field samples.</p

Detection of LAMP result under UV light.

<p>N- negative, P- positive, NC-negative control, PC- positive control.</p

Distribution of quantitative PCR determined parasite densities.

<p>pan- <i>Pan plasmodium</i>, Geometric mean values are indicated by horizontal lines. Geometric mean values are for PCR + 1.8 p/μL (range 0.1–770), for PCR+/ pan HTP-LAMP + 2.5 p/μL (range 0.2–770), for PCR+/ pan-HTP-LAMP– 1.4 p/μL (range 0.1–7) and for Chelex pan-LAMP + 3.4 p/μL (range 0.1–770).</p

Flow chart of high-throughput (HTP)-LAMP evaluation.

<p>Results of Pan <i>Plasmodium</i> HTP-LAMP, confirmed PCR and Chelex LAMP (Ch-LAMP) are summarized. spp-species.</p

Characterization of HTP-LAMP versus PCR discordant samples for diagnosis of <i>Plasmodium</i> infection (N = 31).

<p>Characterization of HTP-LAMP versus PCR discordant samples for diagnosis of <i>Plasmodium</i> infection (N = 31).</p

Additional file 2: of A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting—high coverage and safety, but no significant impact on transmission

Figure S1. Capillary whole blood piperaquine concentrations at day 7 post-dose, stratified by self-reported adherence status. Figure S2. Number of clinical malaria cases as reported through the malaria case notification system from January 2015 to Sept 2017 in Unguja. Figure S3. Weekly number of clinical malaria cases as reported in the Malaria Early Epidemic Detections System in Unguja 2016. (PDF 414 kb