67 research outputs found

    Can Cali measure sustainability in its food systems? Using the Milan Urban Food Policy Pact to gauge progress- Policy brief

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    Cali’s food systems: A diagnostic synthesis to determine priority action areas for sustainable food systems

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    Food systems are complex and dynamic, and their governance and planning directly affect food security and nutritional outcomes across urban, peri-urban, and rural communities. The production, consumption, and disposal of food has profound effects on economic development, environmental sustainability, and public health. Among food systems, these three domains have important linkages and synergies which are conveyed through public goods and public policy. Identifying the components that make up food systems can be challenging, especially for decision makers who need to understand how changing individual components in the system may have broader implications on food security and public health. Without robust, generalizable data to explain the interconnectedness between these domains, policymakers cannot make evidence-based recommendations that foster sustainable practices. Thus, policymakers need decision support tools to identify specific problem and sites of action to develop sustainable solutions. This project compares the 44 Monitoring Framework Indicators from the Milan Urban Food Policy Pact (MUFPP) to existing indicators in Santiago de Cali’s Municipal Development Plan and other governmental reports to measure the city’s progress integrating sustainability in its food systems. The MUFPP is a non-binding international protocol aimed at tackling food- related issues at the urban level by having cities share best practices and monitor their progress towards achieving more sustainable foods systems. Preliminary results observed eight indicators that were measured, twenty-five indicators required review or fine tuning, and eleven indicators were missing altogether, pointing to gaps in data and knowledge and potential food system failures. Based on these gaps, a criteria and methodology were developed to determine priority action areas to improve and encourage the use of sustainable practices. (**includes results from methodology**) Cali is not a MUFPP signatory city, change tense but given the upcoming municipal and departmental elections, this rudimentary food systems assessment is an opportunity to present evidence and engage Cali’s decision makers and researchers as they develop future political and research agendas related to food security, environmental protection, and economic development

    Perspectives on food systems in Santiago de Cali, Colombia

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    The purpose of this brief is to reflect how stakeholders involved in different functional areas of Santiago de Cali’s food systems perceive food and nutrition security and sustainability in the city-region. Eleven interviews were conducted between June and August of 2019, with individuals representing Cali’s municipal government, Valle del Cauca’s departmental government, private enterprise, non-profits, agroecological farmer organizations, consumer advocacy groups, civil society, and academia.1 Individuals were asked to describe the strengths and weaknesses of government programs and describe the factors that impact the ability to achieve food security, improved nutrition, and positive socio-economic outcomes while protecting the environment

    Control-Value Appraisals, Enjoyment, and Boredom in Mathematics:A Longitudinal Latent Interaction Analysis

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    Based on the control-value theory of achievement emotions, this longitudinal study examined students' control-value appraisals as antecedents of their enjoyment and boredom in mathematics. Self-report data for appraisals and emotions were collected from 579 students in their final year of primary schooling over three waves. Data were analyzed using latent interaction structural equation modeling. Control-value appraisals predicted emotions interactively depending on which specific subjective value was paired with perceived control. Achievement value amplified the positive relation between perceived control and enjoyment, and intrinsic value reduced the negative relation between perceived control and boredom. These longitudinal findings demonstrate that control and value appraisals, and their interaction, are critically important for the development of students' enjoyment and boredom over time

    Argentine Intersociety Consensus on Urinary Infection 2018-2019

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    La Sociedad Argentina de Infectolog√≠a y otras sociedades cient√≠ficas han actualizado estas recomendaciones utilizando, adem√°s de informaci√≥n internacional, la de un estudio multic√©ntrico prospectivo sobre infecciones del tracto urinario del adulto realizado en Argentina durante 2016-2017. La bacteriuria asintom√°tica debe ser tratada solo en embarazadas, a quienes tambi√©n se las debe investigar sistem√°ticamente; los antibi√≥ticos de elecci√≥n son nitrofuranto√≠na, amoxicilina, amoxicilina-clavul√°nico, cefalexina y trimetoprimasulfametoxazol. Ante procedimientos que impliquen lesi√≥n con sangrado del tracto urinario se recomienda solicitar urocultivo para pesquisar bacteriuria asintom√°tica, y, si resultara positivo, administrar antimicrobianos seg√ļn sensibilidad desde inmediatamente antes hasta 24 horas luego de la intervenci√≥n. En mujeres, la cistitis puede ser tratada con nitrofurantoina, cefalexina, o fosfomicina y no se recomienda usar trimetoprima-sulfametoxazol o fluoroquinolonas; en pielonefritis puede emplearse ciprofloxacina, cefixima o cefalexina si el tratamiento es ambulatorio o ceftriaxona, cefazolina o amikacina si es hospitalario. En los hombres, las infecciones del tracto urinario se consideran siempre complicadas. Se recomienda tratamiento con nitrofurantoina o cefalexina por 7 d√≠as, o bien monodosis con fosfomicina. Para la pielonefritis en hombres se sugiere ciprofloxacina, ceftriaxona o cefixima si el tratamiento es ambulatorio y ceftriaxona o amikacina si es hospitalario. Se sugiere tratar las prostatitis bacterianas agudas con ceftriaxona o gentamicina. En cuanto a las prostatitis bacterianas cr√≥nicas, si bien su tratamiento de elecci√≥n hasta hace poco fueron las fluoroquinolonas, la creciente resistencia y ciertasdudas sobre la seguridad de estas drogas obligan a considerar el uso de alternativas como fosfomicina.The Argentine Society of Infectious Diseases and other scientific societies have updated these recommendations based on data on urinary tract infections in adults obtained from a prospective multicenter study conducted in Argentina during 2016-2017. Asymptomatic bacteriuria should be treated only in pregnant women, who should also be systematically investigated; the antibiotics of choice are nitrofurantoin, amoxicillin, clavulanic/amoxicillin, cephalexin and trimethoprim-sulfamethoxazole. In procedures involving injury to the urinary tract with bleeding, it is recommended to request urine culture and, in the presence of bacteriuria, antimicrobial treatment according to sensitivity should be prescribed from immediately before up to 24 hours after the intervention. In women, cystitis can be treated with nitrofurantoin, cephalexin or fosfomycin, while trimethoprim-sulfamethoxazole and fluoroquinolones are not recommended; pyelonephritis can be treated with ciprofloxacin, cefixime or cephalexin in ambulatory women or ceftriaxone, cefazolin or amikacin in those who are hospitalized. In men, urinary tract infections are always considered complicated; nitrofurantoin or cephalexin are recommended for 7 days, alternatively fosfomycin should be given in a single dose. In men, ciprofloxacin, ceftriaxone or cefixime are suggested for pyelonephritis on ambulatory treatment whereas ceftriaxone or amikacin are recommended for hospitalized patients. Acute bacterial prostatitis can be treated with ceftriaxone or gentamicin. Fluoroquinolones were the choice treatment for chronic bacterial prostatitis until recently; they are no longer recommended due to the increasing resistance and recent concerns regarding the safety of these drugs; alternative antibiotics such as fosfomycin are to be considered.Fil: Nemirovsky, Corina. Sociedad Argentina de Infectologia; ArgentinaFil: Lopez Furst, Mar√≠a Jos√©. Sociedad Argentina de Infectologia; ArgentinaFil: Pryluka, Daniel. Sociedad Argentina de Infectologia; ArgentinaFil: de Vedia, Lautaro. Sociedad Argentina de Infectologia; ArgentinaFil: Scapellato, Pablo. Sociedad Argentina de Infectologia; ArgentinaFil: Colque, Angel. Sociedad Argentina de Infectologia; ArgentinaFil: Barcelona, Laura. Sociedad Argentina de Infectologia; ArgentinaFil: Desse, Javier. Sociedad Argentina de Infectologia; ArgentinaFil: Caradont, Mat√≠as. Sociedad Argentina de Urolog√≠a; ArgentinaFil: Varcasia, Daniel. Sociedad Argentina de Urolog√≠a; ArgentinaFil: Ipohorski,Gabriel. Federaci√≥n Argentina de Urolog√≠a; ArgentinaFil: Votta, Roberto. Federaci√≥n Argentina de Sociedades de Ginecolog√≠a y Obstetricia; ArgentinaFil: Zylberman, Marcelo. Sociedad Argentina de Medicina; ArgentinaFil: Romani, Adriana de F√°tima. Sociedad Argentina de Medicina; ArgentinaFil: Valdez, Pascual. Sociedad Argentina de Medicina; ArgentinaFil: Penini, Magdalena. Sociedad Argentina de Bacteriolog√≠a, Micolog√≠a y Parasitolog√≠a Cl√≠nica; ArgentinaFil: De Paulis, Adriana. Sociedad Argentina de Bacteriolog√≠a, Micolog√≠a y Parasitolog√≠a Cl√≠nica; ArgentinaFil: Lucero, Celeste. Direcci√≥n Nacional de Instituto de Investigaci√≥n.Administraci√≥n Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbr√°n"; ArgentinaFil: Sandor, Andres. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Contreras, Rosita. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Nannini, Esteban. Sociedad Argentina de Infectolog√≠a; Argentina. Consejo Nacional de Investigaciones Cient√≠ficas y T√©cnicas. Centro Cient√≠fico Tecnol√≥gico Conicet - Rosario. Instituto de Inmunolog√≠a Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias M√©dicas. Instituto de Inmunolog√≠a Clinica y Experimental de Rosario; ArgentinaFil: Ga√Īete, Marcelo. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Ralli, Hector. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Lopardo, Gustavo. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Mykietiuk, Analia. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Aronson, Sandra. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Fern√°ndez Laus, Adriana. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Fern√°ndez Garces, Alejandro. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Rodr√≠guez, Claudia. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Chattas, Ana. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Farina, Javier. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Clara, Liliana. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Nuccetelli, Yanina. Sociedad Argentina de Infectolog√≠a; ArgentinaFil: Amalfa, Flavia. Sociedad Argentina de Infectolog√≠a; Argentin

    BHPR research: qualitative1.‚ÄÉComplex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis

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    Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ‚ôā, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck‚ÄĚ). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?‚ÄĚ). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone‚ÄĚ). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about‚ÄĚ). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes

    The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.

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    Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR‚ÄČ=‚ÄČ2.44, P‚ÄČ=‚ÄČ0.034 and OR‚ÄČ=‚ÄČ3.79; P‚ÄČ=‚ÄČ0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR‚ÄČ=‚ÄČ1.96; P‚ÄČ=‚ÄČ0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors
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