Surface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles for Killing Cancer Cells and Single-Particle-Level Cellular Imaging

The fabrication of novel magnetofluorescent nanoparticles (NPs) by complexation of zinc ions present on the surface of a zinc ferrite nanoparticle (ZnFe₂O₄ NP) with 8-hydroxy-2-quinolinecarboxaldehyde (HQCald) is reported. The as-prepared HQCald-complexed ZnFe₂O₄ NPs showed good quantum yield (3.62%), high photostability, considerable excited-state lifetime (5.31 ns), and high saturation magnetization (12.7 emu/g). These magnetofluorescent NPs demonstrated bioimaging capability at both the ensemble- and single-particle levels and in vitro magnetic targeting. Moreover, the pronounced antiproliferative efficacy of these NPs against cancer cells, with appropriate targeting strategies, can lead to potential cancer theranostics

Surface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles for Killing Cancer Cells and Single-Particle-Level Cellular Imaging

The fabrication of novel magnetofluorescent nanoparticles (NPs) by complexation of zinc ions present on the surface of a zinc ferrite nanoparticle (ZnFe₂O₄ NP) with 8-hydroxy-2-quinolinecarboxaldehyde (HQCald) is reported. The as-prepared HQCald-complexed ZnFe₂O₄ NPs showed good quantum yield (3.62%), high photostability, considerable excited-state lifetime (5.31 ns), and high saturation magnetization (12.7 emu/g). These magnetofluorescent NPs demonstrated bioimaging capability at both the ensemble- and single-particle levels and in vitro magnetic targeting. Moreover, the pronounced antiproliferative efficacy of these NPs against cancer cells, with appropriate targeting strategies, can lead to potential cancer theranostics

Surface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles for Killing Cancer Cells and Single-Particle-Level Cellular Imaging

The fabrication of novel magnetofluorescent nanoparticles (NPs) by complexation of zinc ions present on the surface of a zinc ferrite nanoparticle (ZnFe₂O₄ NP) with 8-hydroxy-2-quinolinecarboxaldehyde (HQCald) is reported. The as-prepared HQCald-complexed ZnFe₂O₄ NPs showed good quantum yield (3.62%), high photostability, considerable excited-state lifetime (5.31 ns), and high saturation magnetization (12.7 emu/g). These magnetofluorescent NPs demonstrated bioimaging capability at both the ensemble- and single-particle levels and in vitro magnetic targeting. Moreover, the pronounced antiproliferative efficacy of these NPs against cancer cells, with appropriate targeting strategies, can lead to potential cancer theranostics

Surface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles for Killing Cancer Cells and Single-Particle-Level Cellular Imaging

The fabrication of novel magnetofluorescent nanoparticles (NPs) by complexation of zinc ions present on the surface of a zinc ferrite nanoparticle (ZnFe₂O₄ NP) with 8-hydroxy-2-quinolinecarboxaldehyde (HQCald) is reported. The as-prepared HQCald-complexed ZnFe₂O₄ NPs showed good quantum yield (3.62%), high photostability, considerable excited-state lifetime (5.31 ns), and high saturation magnetization (12.7 emu/g). These magnetofluorescent NPs demonstrated bioimaging capability at both the ensemble- and single-particle levels and in vitro magnetic targeting. Moreover, the pronounced antiproliferative efficacy of these NPs against cancer cells, with appropriate targeting strategies, can lead to potential cancer theranostics

Surface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles for Killing Cancer Cells and Single-Particle-Level Cellular Imaging

The fabrication of novel magnetofluorescent nanoparticles (NPs) by complexation of zinc ions present on the surface of a zinc ferrite nanoparticle (ZnFe₂O₄ NP) with 8-hydroxy-2-quinolinecarboxaldehyde (HQCald) is reported. The as-prepared HQCald-complexed ZnFe₂O₄ NPs showed good quantum yield (3.62%), high photostability, considerable excited-state lifetime (5.31 ns), and high saturation magnetization (12.7 emu/g). These magnetofluorescent NPs demonstrated bioimaging capability at both the ensemble- and single-particle levels and in vitro magnetic targeting. Moreover, the pronounced antiproliferative efficacy of these NPs against cancer cells, with appropriate targeting strategies, can lead to potential cancer theranostics

Surface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles for Killing Cancer Cells and Single-Particle-Level Cellular Imaging

The fabrication of novel magnetofluorescent nanoparticles (NPs) by complexation of zinc ions present on the surface of a zinc ferrite nanoparticle (ZnFe₂O₄ NP) with 8-hydroxy-2-quinolinecarboxaldehyde (HQCald) is reported. The as-prepared HQCald-complexed ZnFe₂O₄ NPs showed good quantum yield (3.62%), high photostability, considerable excited-state lifetime (5.31 ns), and high saturation magnetization (12.7 emu/g). These magnetofluorescent NPs demonstrated bioimaging capability at both the ensemble- and single-particle levels and in vitro magnetic targeting. Moreover, the pronounced antiproliferative efficacy of these NPs against cancer cells, with appropriate targeting strategies, can lead to potential cancer theranostics

Surface-Complexed Zinc Ferrite Magnetofluorescent Nanoparticles for Killing Cancer Cells and Single-Particle-Level Cellular Imaging

The fabrication of novel magnetofluorescent nanoparticles (NPs) by complexation of zinc ions present on the surface of a zinc ferrite nanoparticle (ZnFe₂O₄ NP) with 8-hydroxy-2-quinolinecarboxaldehyde (HQCald) is reported. The as-prepared HQCald-complexed ZnFe₂O₄ NPs showed good quantum yield (3.62%), high photostability, considerable excited-state lifetime (5.31 ns), and high saturation magnetization (12.7 emu/g). These magnetofluorescent NPs demonstrated bioimaging capability at both the ensemble- and single-particle levels and in vitro magnetic targeting. Moreover, the pronounced antiproliferative efficacy of these NPs against cancer cells, with appropriate targeting strategies, can lead to potential cancer theranostics

Synergistic Anticancer Activity of Fluorescent Copper Nanoclusters and Cisplatin Delivered through a Hydrogel Nanocarrier

Highly fluorescent red copper nanoclusters (Cu NCs) were synthesized in aqueous medium in the presence of dihydrolipoic acid and poly­(vinylpyrrolidone) (PVP). The Cu NCs, in solid form, were stable, retained their optical properties for a month, and could be redispersed for use when required. The NCs in aqueous medium exhibited pH-tunable reversible optical properties. The PVP stabilized NCs, when converted into hydrogel by cross-linking with poly­(vinyl alcohol), delivered anticancer drug to cervical cancer (HeLa) cells, thereby inducing apoptotic cell death. The red emission properties of the Cu NCs in the hydrogel were used for optical imaging as well as for flow cytometric probe of cellular uptake. Cell viability assay, Caspase3 assay, and cell cycle analyses demonstrated that the Cu NCs present in the hydrogel composite exhibited synergy of action, along with the drug, cisplatin, against HeLa cells

Blue-Emitting Copper Nanoclusters Synthesized in the Presence of Lysozyme as Candidates for Cell Labeling

Highly fluorescent copper nanoclusters (Cu NCs) have been synthesized using single-step reduction of copper sulfate by hydrazine in the presence of lysozyme. The fluorescence quantum yield was measured to be as high as 18%. The emission was also found to be dependent on the excitation wavelength. Mass spectrometric analyses indicated the presence of species corresponding to Cu₂ to Cu₉. Transmission electron microscopic analyses indicated the formation of agglomerated particles of average diameter of 2.3 nm, which were constituted of smaller particles of average diameter of 0.96 nm. They were found to be stable between pH 4 and 10 and in addition having excellent chemical and photostability. The noncytotoxic NCs were used to successfully label cervical cancer HeLa cells

Protein-Based Multifunctional Nanocarriers for Imaging, Photothermal Therapy, and Anticancer Drug Delivery

We report a simple approach for fabricating plasmonic and magneto-luminescent multifunctional nanocarriers (MFNCs) by assembling gold nanorods, iron oxide nanoparticles, and gold nanoclusters within BSA nanoparticles. The MFNCs showed self-tracking capability through single- and two-photon imaging, and the potential for magnetic targeting in vitro. Appreciable <i>T</i>₂-relaxivity exhibited by the MFNCs indicated favorable conditions for magnetic resonance imaging. In addition to successful plasmonic-photothermal therapy of cancer cells (HeLa) in vitro, the MFNCs demonstrated efficient loading and delivery of doxorubicin to HeLa cells leading to significant cell death. The present MFNCs with their multimodal imaging and therapeutic capabilities could be eminent candidates for cancer theranostics