Supplementary material for <b>Genetic parameters, GWAS and selection perspective on gestation length in 16 French cattle breeds </b><i>by Jourdain et al., 2024</i>

The file contents all the supplementary materials mentionned in the article Genetic parameters, GWAS and selection perspective on gestation length in 16 French cattle breeds by Jourdain et al., 2024.Page 1 & 2 are presented Supplementary tables 1 & 2Page 3 to 34 are presented Supplementary figures 1 to 16, including the descriptive data of gestation length for each of the breeds used in the paper </p

List of regions displaying significant deficit of homozygotes.

<p>Homoz: homozygote, freq: frequency. Only regions with Chi-square test p-values lower than 10⁻⁴ are shown except HH2 (italic), previously reported by <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065550#pone.0065550-VanRaden1" target="_blank">[13]</a>.</p

Loss in calving rate in matings between carrier sires and daughters of carrier sires.

*<p>p<0.05, **p<0.01 and ***p<0.001 versus control group (t-test). Haplotypes with significant negative effects on conception rate in both heifers and adult cows in matings at risk are shown in bold type. Nb: number. a: no mating at risk was observed between carriers of these haplotypes and daughters of carrier bulls during the period of time studied (see methods).</p

List of candidate mutations for embryonic lethal defects.

*<p>: mutations with damaging predicted effect on the structure and function of the protein. In bold are shown the strongest candidate mutations for each haplotype. Mutation g.49942403T>C, predicted to affect BCAR3 splicing, was not retained as a plausible causative mutation since deficiency in BCAR3 is not lethal in mouse <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065550#pone.0065550-Near1" target="_blank">[17]</a>. MIS18A p.C13Y substitution was also not retained as a plausible causative mutation as described in the manuscript.</p