4 research outputs found

    Patients suffering from BPD are less heat pain sensitive independent of the <i>val158met</i> polymorphism.

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    <p>(A) Genotype distribution of the <i>val158met</i> polymorphism in healthy controls (open) and BPD patients (filled bars) do not differ. (B) Heat pain perception was markedly reduced in BPD. Dose-response function in the pretest session (circles) and stimulus temperatures applied during fMRI (squares) did significantly differ between controls and BPD (ns p>0.4; * p<0.05; ** p<0.01; *** p<0.001, students t-test).</p

    Brain areas activated in response to subjectively adjusted heat pain correlate with COMT val158met polymorphism.

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    <p>During subjectively similar intense heat pain perception (individual temperature in BPD 43°C in healthy controls), posterior parietal cortex (A), lateral globus pallidus (LGP; B) and the posterior cingulate cortex (PPC; C) displayed significant correlation with COMT-polymorphism. Labelling as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023658#pone-0023658-g002" target="_blank">Fig. 2</a>,* p<0.05.</p

    Association between COMT genotype and fMRI activation during painful stimulation in frontal brain areas.

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    <p>Significant correlations were observed for both stimulus conditions within the dorsolateral prefrontal cortex (DLPFC; A,B). Furthermore, the posterior parietal cortex (PPC; C) and the lateral globus pallidus (LGP; D) also displayed significant correlation during both conditions. Statistics and regression lines for group means are shown in gray (all 50 subjects), black (BPD), and dashed (Control), respectively; significant Pearson product moment correlation * p<0.05, ** p<0.01, *** p<0.001, versus r = 0.</p