Pembiasaan Perilaku Hidup Bersih Anak Usia Dini di Paud Melati Jaya Jungkat Kecamatan Siantan

This research aims to find out the conditioning of hygienic behavior in early childhood in ECD Melati Jaya Village Jungkat District of Siantan method used qualitatively to solve the problem of giving a picture based on the facts that seem at time of study sample are teachers and parents the technique used in this study was the observation technique by means of observation quidelines interview teachniques by means of interviews and documentation technique with a documentation too from the results and discussion of the research concluded that the conditioning of healthy behavior in early childhood in ECD Melati Jaya Village Jungkat districts Siantan that programs, forms, and methods to ensure children train and maintain healthy behavior habituation

Blinded, multi-centre evaluation of drug-induced changes in contractility using human induced pluripotent stem cell-derived cardiomyocytes

Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety pharmacology, we quantified changes in contractility, voltage, and/or Ca2+ handling in 2D monolayers or 3D engineered heart tissues (EHTs). Protocols were unified via a drug training set, allowing subsequent blinded multicenter evaluation of drugs with known positive, negative, or neutral inotropic effects. Accuracy ranged from 44% to 85% across the platform-cell configurations, indicating the need to refine test conditions. This was achieved by adopting approaches to reduce signal-to-noise ratio, reduce spontaneous beat rate to ≤ 1 Hz or enable chronic testing, improving accuracy to 85% for monolayers and 93% for EHTs. Contraction amplitude was a good predictor of negative inotropes across all the platform-cell configurations and of positive inotropes in the 3D EHTs. Although contraction- and relaxation-time provided confirmatory readouts forpositive inotropes in 3D EHTs, these parameters typically served as the primary source of predictivity in 2D. The reliance of these “secondary” parameters to inotropy in the 2D systems was not automatically intuitive and may be a quirk of hiPSC-CMs, hence require adaptations in interpreting the data from this model system. Of the platform-cell configurations, responses in EHTs aligned most closely to the free therapeutic plasma concentration. This study adds to the notion that hiPSC-CMs could add value to drug safety evaluation

Results of the COVID-19 mental health international for the general population (COMET-G) study.

INTRODUCTION: There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study. MATERIAL AND METHODS: During the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 ± 13.61; 34.05% males aged 34.90±13.29 and 1.10% other aged 31.64±13.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively. STATISTICAL ANALYSIS: Descriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables. RESULTS: Probable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed. CONCLUSIONS: The final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them

Treatment and long-term outcome of mental disorders: the grim picture from a quasi-epidemiological investigation in 54,826 subjects from 40 countries

This study registered rates of specific treatment options for mental disorders as well as their long-term outcome. The history of mental disorders was used as a proxy for diagnosis. The data came from the COMET-G study (40 countries; 54,826 subjects, 64.73 % females, 35.45±13.51 years old). The analysis included descriptive statistics, Risk Ratios, t-tests, and ANCOVA's. .14 % reported a history of any mental disorder (depression >12 %, non-affective psychosis and Bipolar disorder 1 % each, >20 % self-injury, >10 % had attempted suicide, 7.17 % illegal substance abuse). Most patients were not under any kind of treatment (59.44 %) and most were not receiving treatment as recommended (e.g. 90 % of Bipolar and 2/3 of psychotic patients). No treatment at all and psychotherapy as monotherapy were consistently related to poorer outcomes. In anxiety or depression, only antidepressant monotherapy and benzodiazepines, in Bipolar disorder only antipsychotic monotherapy in males and antidepressant monotherapy in females and in non-affective psychosis antipsychotics and psychotherapy in females only, were related to good outcomes. No treatment modality was related to a good outcome in those with a history of self-harm, suicidal attempts, or illegal substance use. Only depression and treatment with antidepressants were related to metabolic syndrome. In the community, the overwhelming majority of mental patients do not receive appropriate treatment or, even worse, no treatment at all. The outcome is unfavourable for the majority and only a few selective treatment options seem to make a difference. [Abstract copyright: Copyright © 2025. Published by Elsevier B.V.

Premenstrual Gentle Yoga melalui Media Terapi Musik Relaksasi sebagai Upaya Mengatasi Gejala Premenstrual Syndrom (Pms) di Desa Jempong Timur Wilayah Kerja Puskesmas Karang Pule

Berdasarkan analisis situasi yang teridentifikasi teradapat beberapa permasalahan yang dihadapi oleh mitra, yaitu sebagian besar remaja mengalami ketidaknyamanan menjelang menstruasi (7-10 Hari sebelum menstruasi) sebesar 80%, sebesar 25% remaja mengkonsumsi obat anti nyeri saat menstruasi dan tidak mengetahui cara penanganan selain mengkonsumsi obat anti nyeri, belum memiliki pengetahuan tentang Premenstrual Gentle Yoga dan belum mampu untuk melakukannya. Sehingga penyelesaian permasalahan yang dihadapi oleh mitra yang diberikan yaitu dengan memberikan penyuluhan Premenstrual Gentle Yoga Melalui Daring Sebagai Upaya Mengatasi Gejala Premenstrual Syndrome (PMS). Kegiatan ini diharapakan akan terus berlanjut dilakukan oleh remaja melalui Posyandu Remaja yang ada di Desa Jempong Timur. Metode kegiatan yang digunakan adalah dengan metode penyuluhan dan pelatihan. Hasil kegiatan menunjukkan bahwa terjadi peningkatan pengetahuan sebelum dan setelah kegiatan, dari 75% meningkat menjadi 85%. Potensi hasil pelaksanaan PKM-M yang telah dilaksanakan kurang lebih 1 bulan adalah remaja merasakan sekali manfaat setelah melakukan yoga, nyeri yang dirasakan agak berkurang walau belum hilang dikarenakan pelaksanaan baru dilakukan sekali dan dilakukan kembali oleh remaja dirumah masing-masing

Pengelolaan Uang Saku Siswa pada Masa Pandemi Covid-19 di SMK Bina Mandiri Multimedia

Tujuan dari Kegiatan Pengabdian Kepada Masyarakat adalah untuk melaksanakan salah satu Tri Dharma Perguruan Tinggi. Selain itu agar para siswa dan siswi SMK Bina Mandiri Multimedia Cileungsi, Bogor dapat lebih memahami bagaimana penggunaan dan pemanfaatan uang dimasa Pandemi seperti saat ini agar lebih tepat, cermat dan hemat sesuai dengan kebutuhan, tidak boros atau mempergunakan uang dengan tidak tepat. Secara umum penggunaan metode pada kegiatan ini adalah dengan memberikan pengetahuan dan pendampingan berupa sosialisasi kepada siswa dan siswi SMK Bina Mandiri Multimedia Cileungsi tentang bagaimana cara mengelola keuangan terutama uang saku yang baik. Tujuan agar para siswa dan siswi mampu mengelola keuangan harian mereka dengan cermat yang tentunya harus didasari dengan memiliki pengetahuan manajemen keuangan yang baik. Hasil pengabdian masyarakat yang diperoleh adalah bertambahnya keilmuan dan pengalaman para siswa siswi SMK Bina Mandiri Cileungsi , Bogor yang selama ini masih minim tentang manajemen keuangan, cara memanfaatkan serta mengelola uang saku atau jajan yang diberikan oleh orang tua sehingga masih bisa menyisihkan untuk menabung atau bahkan untuk membeli quota untuk proses belajar mengajar atau berkomunikasi dengan keluarga

Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes

Abstract Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety pharmacology, we quantified changes in contractility, voltage, and/or Ca2+ handling in 2D monolayers or 3D engineered heart tissues (EHTs). Protocols were unified via a drug training set, allowing subsequent blinded multicenter evaluation of drugs with known positive, negative, or neutral inotropic effects. Accuracy ranged from 44% to 85% across the platform-cell configurations, indicating the need to refine test conditions. This was achieved by adopting approaches to reduce signal-to-noise ratio, reduce spontaneous beat rate to ≤ 1 Hz or enable chronic testing, improving accuracy to 85% for monolayers and 93% for EHTs. Contraction amplitude was a good predictor of negative inotropes across all the platform-cell configurations and of positive inotropes in the 3D EHTs. Although contraction- and relaxation-time provided confirmatory readouts forpositive inotropes in 3D EHTs, these parameters typically served as the primary source of predictivity in 2D. The reliance of these “secondary” parameters to inotropy in the 2D systems was not automatically intuitive and may be a quirk of hiPSC-CMs, hence require adaptations in interpreting the data from this model system. Of the platform-cell configurations, responses in EHTs aligned most closely to the free therapeutic plasma concentration. This study adds to the notion that hiPSC-CMs could add value to drug safety evaluation.</jats:p