A Kinetic Model for Cell Damage Caused by Oligomer Formation

It is well-known that the formation of amyloid fiber may cause invertible damage to cells, while the underlying mechanism has not been fully uncovered. In this paper, we construct a mathematical model, consisting of infinite ODEs in the form of mass-action equations together with two reaction-convection PDEs, and then simplify it to a system of 5 ODEs by using the maximum entropy principle. This model is based on four simple assumptions, one of which is that cell damage is raised by oligomers rather than mature fibrils. With the simplified model, the effects of nucleation and elongation, fragmentation, protein and seeds concentrations on amyloid formation and cell damage are extensively explored and compared with experiments. We hope that our results can provide a valuable insight into the processes of amyloid formation and cell damage thus raised.Comment: 16 pages+ 5 figures for maintext; 8 pages+ 4 figures for Supporting Material

Experiences of 30 Years in Right Trisectionectomy for Huge Liver Tumor

Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer-related deaths. Up to now, surgery remains to be the main curative strategy for hepatocellular carcinoma. In this article the author summarizes his experiences of 30 years in right trisectionectomy for huge liver tumor. A total of 459 primary liver cancer patients were hepatomized in author\u27s group. Among them, 33 cases of right trisectionectomies were performed under continuous single interruption of the porta hepatis. The 1-, 3-, and 5-year survival rates were 71.9%, 40.6%, and 34.4%, respectively. The longest cancer-free survival of right trisectionectomy in our group is 26 years. In the author\u27s another cohort, 51 patients underwent hepatectomy without allogeneic blood transfusion. Compared with the control group containing 60 patients who underwent hepatectomy with allogeneic blood transfusion, the morbidity and recurrence rates in the group without allogeneic blood transfusion were significantly decreased (P < 0.05). Surgical anatomy study of the hepatic veins and case reports are also included in this article. Taken together, it is obvious that right trisectionectomy under continuous single interruption of the porta hepatis without allogeneic blood transfusion would benefit the patient with resectable huge HCC