Response To Intervention For Young Children With Mild, Moderate/Severe Cognitive Disabilities: Literature Review

This study has discussed in-depth information about understanding the Response to Intervention (RTI) linking with children from pre-school to kindergarten (three to eight years old) who have Cognitive Disabilities (CD), including different levels from mild to moderate and/or severe.  The study consists of five main sections – RTI, CD, RTI Linking with CD, teaching methods for children with CD, and how RTI helps disability in school. Each section is presented in comprehensive detail

Evaluating General Diploma Program of Education

Abstract: The purpose of the study is to evaluate students’ perceptions of the General Diploma Program at the Faculty of Education in King AbdulAziz University. The study adopted a descriptive analytical approach through a questionnaire which consisted of (57) items divided into six domains. The researcher calculated reliability and validity then administrated the questionnaire to all students registered in the General Diploma in the academic year 1435-1436H totaling (106) students. Of these, (82) responded to the questionnaire. The findings of the study were as follows: students rated all of the quality standards as being average. Students were most satisfied with the teaching domain, and least with facilities, and equipment. There were no significant statistical differences between the means of the samples’ responses on all domains attributed to major or post variables except in administrating the program domain as differences were in favor of the post variable. There were significant statistical differences attributed to service years in program mission and goals domain، managing the program، learning and teaching and student’s services. While، there were significant statistical differences attributed to experience years in courses and equipment and facilities domains. Keywords: Evaluation - Quality - Educational programs

Design of a Model of Forearm Bone Fractures for Educational Purposes

This work explore new approach to demonstrate possible forearm fractures in humans as an educating means for student radiographers. The Design of abnormal bones are not normally available as phantoms, the manufacturer usually produce normal human musculoskeletal models for educational purpose. Hence fractures and abnormalities are usually first time observed by the students in clinical practice at the hospital, the author believe that this work can positively improve the clinical skill laboratories sessions at an earlier stage prior to the hospital training. With the help of such phantom, it can be considered as foundation practical sessions added to radiographic techniques, clinical practice and pathology courses to students radiographers and technologist. Moreover, a model was developed with high quality and low cost produced by local materials for medical education purposes. The present result indicated that the use of models for education and training purposes where interactive training tools will improve the learning experience, and reduces the time on task for students and the material costs as well. Keywords: Forearm, Fractures, Educational Purpose

Dermatological Lesions of Cholesterol Embolization Syndrome and Kaposi Sarcoma Mimic Primary Systemic Vasculitis: Case Report Study

Primary systemic vasculitis can present with a wide spectrum of manifestations ranging from systemic non-specific features such as fever, malaise, arthralgia, and myalgia to specific organ damage. We describe two cases of cholesterol embolization syndrome and Kaposi sarcoma mimicking primary systemic vasculitis, both of which were characterized by features such as livedo reticularis, blue toe syndrome, a brown, purpuric skin rash, and positive p-ANCA associated with Kaposi sarcoma. Establishing the right diagnosis was challenging, and thus we aim in this study to highlight the possible ways to distinguish them from primary systemic vasculitis. Keywords: Dermatological lesions, Cholesterol embolization syndrome, Kaposi sarcoma, vasculitis mimic

A case of atypical systemic primary carnitine deficiency in Saudi Arabia

Systemic primary carnitine deficiency (SPCD) is an autosomal recessive inborn error of fatty acid metabolism caused by a defect in the transporter responsible for moving carnitine across plasma membrane. The clinical features of SPCD vary widely based on the age of onset and organs involved. During infancy, patients might show episodes of hypoketotic hypoglycemia, hepatomegaly, elevated transaminases, and hyperammonemia. Skeletal myopathy, elevated creatine kinase, and cardiomyopathy are the main manifestations in children with SPCD, while in adults, the disorder is usually manifested as cardiomyopathy, arrhythmias, or fatigability. Here, we report a 5-year-old boy with SPCD that presented as dilated cardiomyopathy with atypical features, such as anemia, respiratory distress, and proximal muscle weakness. This report supports considering carnitine deficiency treatment in the work-up of unexplained pediatric dilated cardiomyopathy

BreachSeek: A Multi-Agent Automated Penetration Tester

The increasing complexity and scale of modern digital environments have exposed significant gaps in traditional cybersecurity penetration testing methods, which are often time-consuming, labor-intensive, and unable to rapidly adapt to emerging threats. There is a critical need for an automated solution that can efficiently identify and exploit vulnerabilities across diverse systems without extensive human intervention. BreachSeek addresses this challenge by providing an AI-driven multi-agent software platform that leverages Large Language Models (LLMs) integrated through LangChain and LangGraph in Python. This system enables autonomous agents to conduct thorough penetration testing by identifying vulnerabilities, simulating a variety of cyberattacks, executing exploits, and generating comprehensive security reports. In preliminary evaluations, BreachSeek successfully exploited vulnerabilities in exploitable machines within local networks, demonstrating its practical effectiveness. Future developments aim to expand its capabilities, positioning it as an indispensable tool for cybersecurity professionals.7 pages, 6 figure

SYNERGISTIC ANTIOSTEOPOROTIC EFFECT OF LEPIDIUM SATIVUM AND ALENDRONATE IN GLUCOCORTICOID-INDUCED OSTEOPOROSIS IN WISTAR RATS

Bisphosphonates (BP) therapy is a vital option to reduce the risk of bone fracture in people who have osteoporosis. However, Bisphosphonate have displayed several side effects. Lepidium sativum (LS) plant and seeds has been used in traditional folk medicine as a mediator for bone fractures. Therefore, we aimed to compare the biochemical effects of LS alone (2% LS in diet, n=8), BP (Alendronate, 70 mg/kg s.c.; n=8) alone, or LS and BP combined in a rat model of glucocorticoid-induced osteoporosis (GIO) by injecting methylprednisolone 3.5 mg/kg per day for 4 weeks. Serum calcium (Ca), albumin, phosphorus (PO4), bone-specific alkaline phosphatase (b-ALP), and tartrate-resistant acid phosphatase (TRAP) were measured 4 weeks after induction of GIO. GIO-group showed significantly increased serum TRAP and decreased b-ALP. GIO-group also showed significantly decreased serum PO4 and unaltered Ca concentrations. Histological examination of GIO-group tibia bones indicates an osteoporotic changes and a concomitant decrease in percentage of trabecular area/bone marrow area (PTB) in the proximal femoral epiphysis. Treatment with either LS and/or BP ameliorated the above mentioned changes with variable degrees; with a net results of enhanced serum calcium, bone architecture, PTB, b-ALP and decreased TRAP in LS and LS+BP groups compared to that of animals treated with Alendronate alone. In conclusion, our findings present evidence supporting the potential benefits of LS in reducing the burden of GCs on bone health

Foot Function Index for Arabic-speaking patients (FFI-Ar) : translation, cross-cultural adaptation and validation study

Background: Foot Function Index (FFI) is a valid and reliable outcome measure, which is widely used to measure the foot and ankle functional level and disorders. Until now, no validated Arabic version of the FFI is available. This study was conducted at a tertiary care hospital in Riyadh, Saudi Arabia. The purpose of this project was to translate and adapt the FFI into Arabic and to evaluate its psychometric properties of validity and reliability. Methods: The study consisted of two phases. The first phase was the translation and cultural adaptation of the FFI to Arabic. The next phase involved, testing the psychometric properties of the Arabic version of the FFI on a sample of 50 consecutive participants which included internal consistency, test–retest reliability, floor and ceiling effects and construct validity. Results: The mean age of the study participants was 38 ± 12.94 years. Both the genders were evenly enrolled with 50% of the participants as male and 50% as female. Majority of them complained of plantar fasciopathy (32%) followed by pes planus (22%) and ankle sprain (18%). The scores of FFI-Ar were normally distributed, confirmed by a significant Shapiro–Wilk test. The mean value of FFI-Ar total score was 47.73 ± 19.85. There were no floor or ceiling effects seen in any of the subscales and total score. The internal consistency was good with the Cronbach’s alpha value of 0.882, 0.936 and 0.850 for the pain, disability and activity limitation subscales, respectively. The reproducibility of the FFI-Ar was analysed by intra-class correlation coefficient which revealed good to excellent test–retest reliability. A significant correlation was found between FFI-Ar and SF-36 and numeric rating scale (NRS) confirming its construct validity. Conclusion: The FFI-Arabic version showed good validity and reliability in patients with foot and ankle problems. This tool can be used in usual practice and research for analysing foot and ankle disorders in Arabic-speaking people

An Overview Organophosphate Poisoning, Role Of Anesthesia, Pharmacist, Clinical Laboratory And Paramedics In The Management Approach

Organophosphates are compounds that are frequently employed as pesticides. They function to block acetylcholinesterase, which results in an accumulation of acetylcholine at muscarinic and nicotinic receptors located all throughout the body. Although poisonings are typically thought of as low-volume, chronic cases that are caused by agricultural exposures, they can also manifest as attempts at suicide that are caused by the consumption of organophosphates. When organophosphate poisoning occurs, especially when substantial quantities are consumed, it is imperative that treatment be initiated as quickly and effectively as possible. Literature review give an example that demonstrates how to effectively manage severe organophosphate toxicity symptoms. In the management approach, the roles of anesthesia, chemist, clinical laboratory, and paramedics are extremely important. They work together as a collaborative team beginning with prehospital care and continuing through emergency department admissions and intensive care unit admissions