External debt sustainability under different policy rules

The paper develops a Kaleckian macroeconomic model which discusses the conditions that may lead to an external debt crisis in a small developing economy fully integrated to global goods and financial markets. The focus is on how policy rules affect the stability of the economy. Two kinds of policy rules are discussed, namely an inflation rate target and a real exchange rate target, implemented through an interest rate operation procedure (IROP). It is argued that in both cases the evolution of the real exchange rate should be closely monitored to avoid external instability.central banks, open economy, external crisis

Raman evidence for pressure-induced formation of diamondene.

Despite the advanced stage of diamond thin-film technology, with applications ranging from superconductivity to biosensing, the realization of a stable and atomically thick two-dimensional diamond material, named here as diamondene, is still forthcoming. Adding to the outstanding properties of its bulk and thin-film counterparts, diamondene is predicted to be a ferromagnetic semiconductor with spin polarized bands. Here, we provide spectroscopic evidence for the formation of diamondene by performing Raman spectroscopy of double-layer graphene under high pressure. The results are explained in terms of a breakdown in the Kohn anomaly associated with the finite size of the remaining graphene sites surrounded by the diamondene matrix. Ab initio calculations and molecular dynamics simulations are employed to clarify the mechanism of diamondene formation, which requires two or more layers of graphene subjected to high pressures in the presence of specific chemical groups such as hydroxyl groups or hydrogens

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial.

There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ) requires a high concentration of the drug.To evaluate the safety and efficacy of 2 CQ dosages in patients with severe COVID-19. This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon. - Patients were allocated to receive high-dosage CQ (ie, 600 mg CQ twice daily for 10 days) or low-dosage CQ (ie, 450 mg twice daily on day 1 and once daily for 4 days). - Label: Main Outcomes and Measures Primary outcome was reduction in lethality by at least 50% in the high-dosage group compared with the low-dosage group. Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. Outcomes will be presented to day 28. Viral respiratory secretion RNA detection was performed on days 0 and 4. Out of a predefined sample size of 440 patients, 81 were enrolled (41 [50.6%] to high-dosage group and 40 [49.4%] to low-dosage group). Enrolled patients had a mean (SD) age of 51.1 (13.9) years, and most (60 [75.3%]) were men. Older age (mean [SD] age, 54.7 [13.7] years vs 47.4 [13.3] years) and more heart disease (5 of 28 [17.9%] vs 0) were seen in the high-dose group. Viral RNA was detected in 31 of 40 (77.5%) and 31 of 41 (75.6%) patients in the low-dosage and high-dosage groups, respectively. Lethality until day 13 was 39.0% in the high-dosage group (16 of 41) and 15.0% in the low-dosage group (6 of 40). The high-dosage group presented more instance of QTc interval greater than 500 milliseconds (7 of 37 [18.9%]) compared with the low-dosage group (4 of 36 [11.1%]). Respiratory secretion at day 4 was negative in only 6 of 27 patients (22.2%). - Label: Conclusions and Relevance The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir. These findings cannot be extrapolated to patients with nonsevere COVID-19

Estimativa da radiação global incidente em superfícies inclinadas por modelos isotrópicos e índice de claridade

O objetivo deste trabalho foi avaliar o desempenho de modelos isotrópicos de estimativa do total de radiação incidente em superfícies inclinadas e propor estimativas com base nas correlações entre os índices de claridade horizontais e inclinados, em diferentes condições de cobertura de céu, em Botucatu, SP. Foram avaliadas superfícies com inclinação de 12,85º, 22,85º e 32,85º, pelos modelos isotrópicos propostos por Liu & Jordan, Revfeim, Jimenez & Castro, Koronakis, a teoria Circunsolar, e a correlação entre os índices de claridade horizontais e inclinados, para diferentes condições de cobertura de céu. O banco de dados de radiação global utilizado corresponde ao período de 1998 a 2007, com intervalos de 4/1998 a 8/2001 para a inclinação de 22,85º, de 9/2001 a 2/2003 para 12,85º e de 1/2004 a 12/2007 para 32,85º. O desempenho dos modelos foi avaliado pelos indicadores estatísticos erro absoluto médio, raiz quadrada do quadrado médio do erro e índice "d" de Wilmott. Os modelos de Liu & Jordan, Koronakis e de Revfeim apresentaram os melhores desempenhos em dias nublados, em todas as inclinações. As coberturas de céu parcialmente difuso e parcialmente aberto, nos maiores ângulos de inclinação, apresentaram as maiores dispersões entre valores estimados e medidos, independentemente do modelo. As equações estatísticas apresentaram bons resultados em aplicações com agrupamentos de dados mensais

Persons living with AIDS in nurses' social representations: analysis of central, contranormative and attitudinal elements

OBJECTIVES: to describe and analyze the centrality, the mute zone and the attitudes expressed in nurses' social representations of people with Human Immunodeficiency Virus. METHOD: the subjects were 30 nurses from a university hospital in Rio de Janeiro. The data was collected using a Likert scale. RESULTS: the data pointed to a process of representational change regarding Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome, with the assumption of a more positive attitude regarding living with this health issue. The hypothesis of the existence of a mute zone in the representation, comprising elements with a contranormative character, was strengthened. CONCLUSION: the influence of the dynamics of social normativity on how the social representations studied are expressed may contribute to a better understanding of its structuring process. It also helps in the analysis of possible gaps among the nurses' discourses and practices in relation to Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome.OBJETIVOS: describir y analizar la centralidad, la zona muda y las actitudes expresas en las representaciones sociales de enfermeros acerca de la persona con Virus de la Inmunodeficiencia Humana. MÉTODO: los sujetos fueron 30 enfermeros de un hospital universitario de Rio de Janeiro. Los datos fueron colectados utilizando escala tipo likert. RESULTADOS: indicaron un proceso de cambio representacional sobre el Virus de la Inmunodeficiencia Humana/Síndrome da Inmunodeficiencia Adquirida, con la Asunción de actitud más positiva sobre la convivencia con éste agravo. Fue reforzada hipótesis de existencia de zona muda en la representación compuesta por elementos de carácter contra normativo. CONCLUSIÓN: la influencia de la dinámica de normatividad social sobre el modo de expresión de las representaciones sociales estudiadas puede aportar para una mejor comprensión de su proceso de estructuración. Auxilia, también, en el análisis de eventuales desfases entre los discursos y las prácticas de los enfermeros con relación al Virus de la Inmunodeficiencia Humana/Síndrome da Inmunodeficiencia Adquirida.OBJETIVOS: descrever e analisar a centralidade, a zona muda e as atitudes expressas nas representações sociais de enfermeiros, acerca da pessoa com vírus da imunodeficiência humana. MÉTODO: os sujeitos foram 30 enfermeiros de um hospital universitário do Rio de Janeiro. Os dados foram coletados utilizando escala tipo Likert. RESULTADOS: os resultados indicaram um processo de mudança representacional sobre o vírus da imunodeficiência humana/síndrome da imunodeficiência adquirida, com a assunção de atitude mais positiva sobre a convivência com esse agravo. Foi reforçada a hipótese da existência de zona muda na representação composta por elementos de caráter contranormativo. CONCLUSÃO: a influência da dinâmica de normatividade social sobre o modo de expressão das representações sociais estudadas pode contribuir para melhor compreensão do seu processo de estruturação. Auxilia, também, na análise de eventuais defasagens entre os discursos e as práticas dos enfermeiros em relação ao vírus da imunodeficiência humana/síndrome da imunodeficiência adquirida

Improving Cry8Ka toxin activity towards the cotton boll weevil (Anthonomus grandis)

<p>Abstract</p> <p>Background</p> <p>The cotton boll weevil (<it>Anthonomus grandis</it>) is a serious insect-pest in the Americas, particularly in Brazil. The use of chemical or biological insect control is not effective against the cotton boll weevil because of its endophytic life style. Therefore, the use of biotechnological tools to produce insect-resistant transgenic plants represents an important strategy to reduce the damage to cotton plants caused by the boll weevil. The present study focuses on the identification of novel molecules that show improved toxicity against the cotton boll weevil. <it>In vitro </it>directed molecular evolution through DNA shuffling and phage display screening was applied to enhance the insecticidal activity of variants of the Cry8Ka1 protein of <it>Bacillus thuringiensis</it>.</p> <p>Results</p> <p>Bioassays carried out with <it>A. grandis </it>larvae revealed that the LC₅₀of the screened mutant Cry8Ka5 toxin was 3.15-fold higher than the wild-type Cry8Ka1 toxin. Homology modelling of Cry8Ka1 and the Cry8Ka5 mutant suggested that both proteins retained the typical three-domain Cry family structure. The mutated residues were located mostly in loops and appeared unlikely to interfere with molecular stability.</p> <p>Conclusions</p> <p>The improved toxicity of the Cry8Ka5 mutant obtained in this study will allow the generation of a transgenic cotton event with improved potential to control <it>A. grandis</it>.</p

A list of land plants of Parque Nacional do Caparaó, Brazil, highlights the presence of sampling gaps within this protected area

Brazilian protected areas are essential for plant conservation in the Atlantic Forest domain, one of the 36 global biodiversity hotspots. A major challenge for improving conservation actions is to know the plant richness, protected by these areas. Online databases offer an accessible way to build plant species lists and to provide relevant information about biodiversity. A list of land plants of “Parque Nacional do Caparaó” (PNC) was previously built using online databases and published on the website "Catálogo de Plantas das Unidades de Conservação do Brasil." Here, we provide and discuss additional information about plant species richness, endemism and conservation in the PNC that could not be included in the List. We documented 1,791 species of land plants as occurring in PNC, of which 63 are cited as threatened (CR, EN or VU) by the Brazilian National Red List, seven as data deficient (DD) and five as priorities for conservation. Fifity-one species were possible new ocurrences for ES and MG states