The Role of rescue therapies in the treatment of severe ARDS

ARDS is characterized by a non-cardiogenic pulmonary edema with bilateral chest radiograph opacities and hypoxemia refractory to oxygen therapy. It is a common cause of admission to the ICU due to hypoxemic respiratory failure requiring mechanical ventilation. Corticosteroids are not recommended in ARDS patients. Rescue therapies alleviate hypoxemia in patients unable to maintain reasonable oxygenation: recruitment maneuvers, prone positioning, inhaled nitric oxide, high-frequency oscillatory ventilation, and extracorporeal membrane oxygenation improve oxygenation, but their impact on mortality remains unproven. Restrictive fluid management seems to be a favorable strategy with no significant reduction in 60-d mortality. Future studies are needed to clarify the efficacy of these therapies on outcomes in patients with severe ARDS, and institution of these therapies may be considered on a case-by-case basis

Extracorporeal CO2 removal in hypercapnic patients who fail noni nvasive ventialtion and refuse endotracheal intubation. a case series

Noninvasive ventilation (NIV) represents the standard of care for patients with exacerbation of chronic obstructive pulmonary disease. However, NIV fails in almost 40% of the most severe forms of acute hypercapnic respiratory failure and patients must undergo endotracheal intubation and invasive ventilation. Such transition from NIV to invasive ventilation is associated to increased mortality. Under these circumstances, patients may express a clear intention not to be intubated

Enumerating Abelian Returns to Prefixes of Sturmian Words

We follow the works of Puzynina and Zamboni, and Rigo et al. on abelian returns in Sturmian words. We determine the cardinality of the set $\mathcal{APR}_u$ of abelian returns of all prefixes of a Sturmian word $u$ in terms of the coefficients of the continued fraction of the slope, dependingly on the intercept. We provide a simple algorithm for finding the set $\mathcal{APR}_u$ and we determine it for the characteristic Sturmian words.Comment: 19page

Effects of experimental insoles on body posture, mandibular kinematics and masticatory muscles activity. A pilot study in healthy volunteers

BACKGROUND: It has been hypothesized that different plantar sensory inputs could influence the whole body posture and dental occlusion but there is a lack of evidence on this possible association. OBJECTIVES: To investigate the effects of experimental insoles redistributing plantar pressure on body posture, mandibular kinematics and electromyographic (EMG) activity of masticatory muscles on healthy subjects. METHODS: A pilot study was conducted on 19 healthy volunteers that wore custom-made insoles normalizing the plantar pressure distribution for 2 weeks. Body posture parameters were measured by means of an optoelectronic stereophotogrammetric analysis; mandibular kinematics was analyzed by means of gothic arch tracings; superficial EMG activity of head and neck muscles was performed. Measurements were carried out 10 days before the insertion of the insoles, immediately before the insertion, the day after, 7 and 14 days after, in four different exteroceptive conditions. RESULTS: The outcomes of the present study show that insoles do not modify significantly over time the parameters of body posture, SEMG activity of head and neck muscles and mandibular kinematics. CONCLUSIONS: In this pilot study the experimental insoles did not significantly influence the body posture, the mandibular kinematics and the activity of masticatory muscles during a 14-day follow up perio

Intensive archaeological survey at Piscina Torta: use of a low-cost RTK portable kit to materialise a UTM grid on the ground

We tested the use of a low-cost GPS RTK to set up a grid during the intensive archaeological survey of the Piscina Torta site, in the framework of the Salt and Power project of the University of Groningen. We also suggest not using a local grid but the WGS84 UTM grid and naming the single cells with the coordinates of one of its vertices. This would facilitate the use and exchange of the data (e.g. about the potsherds collected in the cell) among the scientific community

Model-Based Fault Detection and Estimation for Linear Time Invariant and Piecewise Affine Systems by Using Quadratic Boundedness

Quadratic boundedness is a notion of stability that is adopted to investigate the design of observers for dynamic systems subject to bounded disturbances. We will show how to exploit such observers for the purpose of fault detection. Toward this end, first of all we present the naive application of quadratic boundedness to construct state observers for linear time-invariant systems with state augmentation, i.e., where additional variables may be introduced to account for the occurrence of a fault. Then a Luenberger observer is designed to estimate the augmented state variable of the system in such a way to detect the fault by using a convenient threshold selection. Finally, such an approach is extended to piecewise affine systems by presenting a hybrid Luenberger observer and its related design based on quadratic boundedness. The design of all the observers for both linear time-invariant and piecewise affine systems can be done by using linear matrix inequalities. Simulation results are provided to show the effectiveness of the proposed approach

Clinical relevance of silent red blood cell autoantibodies.

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Intensive archaeological survey at Piscina Torta:use of a low-cost RTK portable kit to materialise a UTM grid on the ground

We tested the use of a low-cost GPS RTK to set up a grid during the intensive archaeological survey of the Piscina Torta site, in the framework of the Salt and Power project of the University of Groningen. We also suggest not using a local grid but the WGS84 UTM grid and naming the single cells with the coordinates of one of its vertices. This would facilitate the use and exchange of the data (e.g. about the potsherds collected in the cell) among the scientific community