Conspicuous by their Absence: French Canadians and the Settlement of the Canadian West

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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Conspicuous by their Absence: French Canadians and the Settlement of the Canadian West

The failure of French Canadians to settle the Canadian west before 1900, when substantial numbers of anglophones and Europeans were migrating, is a long-standing puzzle. Historians have relied mainly on cultural explanations. Using new data, we demonstrate that anglophones and francophones had very different personal characteristics, so that movement to the west was rarely economically attractive for francophones. However, large-scale migration into New England fitted French Canadians demographic and human capital profile. Even if the United States had imposed immigration restrictions by the 1880s, this would not likely have diverted many French Canadians westward.

Dominion or republic? Migrants to North America from the United Kingdom, 1870–1910

Late nineteenth–century Canada attracted a large number of immigrants from the UK, despite far lower average income per head there than in the US. While urban labour markets in the northern US were much larger than those in Canada, differences in outcomes between UK immigrants in Canadian and in northern US cities were small. Average annual real earnings by occupation group were only 10 to 15 per cent lower in Canadian cities. Individual–level census data indicate that the occupational distribution of UK immigrants in Canada was quite similar to that of their peers in the US

Gênero, o público e o privado Gender, the Public and the Private

Neste artigo, a filósofa política Susan Moller Okin discute as configurações históricas da dicotomia público/privado, analisando seus significados a partir de uma perspectiva de gênero. A ausência de reflexão sobre o gênero - especialmente sob duas formas, a negligência à realidade política das relações familiares e a linguagem 'neutra' - tem levado muitos teóricos, do passado e do presente, a reafirmar essa dicotomia sem levar em conta sua natureza patriarcal. Para Okin, os domínios da vida doméstica (pessoal) e da vida não-doméstica (pública) não podem ser interpretados isoladamente, o que demanda uma revisão profunda dos fundamentos de grande parte da teoria política liberal. A autora enfrenta essa tarefa, abordando problemas importantes, como o valor da privacidade.<br>In this article, the political philosopher Susan Moller Okin discusses the dichotomy public-private from a gendered perspective. Overlooking gender - especially as it assumes the form of overlooking the political reality of the family and gender 'neutral' language - has become, in many past and present authors, a reinforcement of that dichotomy, silencing about its patriarchal nature. As Okin understands it, domestic (personal) sphere and non-domestic (public) sphere can not be interpreted isolatedly, what demands a deep revision of the base of most liberal political theory. The author faces this demand, discussing important problems such as the value of privacy

Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm

To investigate associations in toddlers born extremely preterm (<28 weeks) between neonatal neuroimaging and 18- to 22-month developmental and behavioral outcomes. Cohort analysis from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Surfactant Positive Airway Pressure and Pulse Oximetry Trial Neuroimaging and Neurodevelopmental Outcomes Study of infants born extremely preterm. Subjects underwent cranial ultrasonography and near-term magnetic resonance imaging (MRI). At 18-22 months of corrected age, the assessment included the Brief Infant Toddler Social Emotional Assessment (BITSEA) Problem and Competence Scale scores and the Bayley Scales of Infant Development, Third Edition (Bayley-III). The BITSEA Problem Scale assesses dysregulation; the Competence Scale assesses social-emotional competence. We examined associations of Problem and Competence scores and positive screen rates with cranial ultrasonography and near-term MRI. Mean BITSEA and Bayley-III scores were compared using ANOVA and positive screen rates with the χ2 test. We computed correlations between BITSEA and Bayley-III scores. Of the 397 children, positive BITSEA screens were found in 34% for the Problem score and 26% for the Competence score. Presence of lesions on near-term MRI that included cerebellar lesions were significantly associated with lower BITSEA Competence but not with Problem scores; Competence scores were inversely related to the presence/significance of lesions. Positive screens on Competence scores and on both Competence and Problem scores were significantly associated with Bayley-III cognitive and language scores <85 (P < .001). Social–emotional competence contributes to deficits in cognitive and language development. Presence of injury on near-term MRI that includes cerebellar lesions is associated with later social–emotional competence and may be a useful predictor to guide early assessment and intervention. ClinicalTrials.gov: NCT00063063 and NCT00233324