ENHANCEMENT OF LORNOXICAM SOLUBILITY BY INCLUSION COMPLEXATION WITH CYCLODEXTRIN: PREPARATION AND CHARACTERIZATION

Objective: Lornoxicam is a potent anti-inflammatory drug which has analgesic and antipyretic properties. It is water-insoluble powder. The inclusion complexes of lornoxicam (LOR) with β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPCD) were prepared and characterised in order to improve the solubility of the drug and enhance its bioavailability.Methods: Complexes were prepared by physical mixing and freeze-drying in three different drug/polymer ratios (1:1, 1:2 and 3:2). The solid complexes were characterised through differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray diffraction, nuclear magnetic resonance (NMR) spectroscopy, and Fourier transformed infrared (FTIR) spectroscopy.Results: The data showed that LOR may be complexed with cyclodextrin (CD) forming soluble complexes. The lyophilized 1:2 LOR/HPCD complex is the most soluble.Conclusion: Solubility increases with lyophilization than with physical mixing and by the use of HPCD than βCD in complexation

The Conditions of Amplification for Nano Quantum Diodes

It is well known that nanomaterials are described by quantum laws. In this work quantum treatment for two metal contacts or diodes on a nanoscale was done. A useful expression for the input and output current is found by using the notion of the current density in quantum mechanics. The conditions required by this contact to act as a rectifier and amplifier are discussed. It found that certain restrictions should be imposed on the potential and the wave number for the metal contact to act as an amplifier. This requires the potential barrier to be positive this requires the region of incident current to have work function less than the transmuted one

Randomized Controlled Trial to Compare the Safety and Efficacy of Tamsulosin, Solifenacin, and Combination of Both in Treatment of Double-J Stent-Related Lower Urinary Symptoms

Purpose. We evaluated the effectiveness and safety of tamsulosin, solifenacin, and combination of both in reducing double-J stent-related lower urinary symptoms. Materials and Methods. A total of 338 patients with double-J ureteral stenting were randomly divided, postoperatively, into 4 groups. In group I (), no treatment was given (control group), group II () received tamsulosin 0.4 mg daily, group III () received solifenacin 10 mg daily, and group IV () received a combination of both medications. Before insertion and 2 weeks after, all patients completed the International Prostate Symptom Score (IPSS), quality of life component of the IPSS (IPSS/Qol), Overactive Bladder Questionnaire (OAB-q), and Visual Analogue Pain Scale (VAPS) questionnaire. Results. The demographics and preoperative questionnaires scores of all groups were comparable. There were statistically significant differences in all scores in favour of groups II, III, and IV as compared to control group ( value < 0.005). Group IV showed statistically significant differences in total IPSS, QoL score, and OAB-q score as compared to groups II and III ( value < 0.001). Conclusions. Combined therapy of tamsulosin and solifenacin significantly alleviated lower urinary symptoms associated with double-J stents as compared to either medication alone

Emotions recognition from human facial images based on fast learning network

Systems of facial emotion recognition have witnessed a high significance in the research field. The face emotions are based on human facial expressions which play a crucial role in silent communication. Machine learning algorithms have widely used in systems of human facial emotion detection from images. However, many systems suffer from low accuracy rate. In this paper, we present a system of facial emotion recognition by using images. In this proposed system, the samples of facial emotions have taken from Yale Face database. In addition, the histograms of oriented gradients (HOG) is used to extract features from the images. The extracted features will feed the fast learning network (FLN) algorithm for the classification part to identify the images of facial emotions with respect to their subjects. Many evaluation measurements have used to evaluate the performance of the proposed system. Based on the results of the experiment, the proposed system achieves 95.04% for the highest accuracy, 72.73% precision. Also, the results of the proposed system in terms of recall, f-measure, and G-main are all equal to 72.73%, respectively

Ear recognition system using random forest and histograms of oriented gradients techniques

In recent years, systems of ear recognition are considered a significant topic of research in the biometrics field. In such systems, the models of machine learning represent a principal part in order to recognise humans’ identities by using their ear images. In this paper, a system of ear recognition is proposed by using random forest (RF) and histograms of oriented gradients (HOG) techniques. The HOG is used to extract features from ear images. Subsequently, these extracted features will be fed to the RF classifier to classify the ear images with respect to the classes. In this study, the ear images have been selected from the Indian Institute of Technology Delhi, second version (IITD II). The performance of the proposed system has evaluated by using different evaluation measures such as accuracy, specificity, and G-mean. The experimental results show that the proposed system for ear recognition obtains accuracy up to 99.69%. Furthermore, this system archives 99.84% and 80.78% for specificity and G-mean, respectively. The proposed system has the ability to identify persons through their ear images effectively

A Valuable and Intuitive Diagnostic tool for Acute Kidney Injury in Liver Cirrhosis is the Fractional Excretion of Urea and Sodium

Background: Prerenal and renal acute kidney injury (AKI) phenotypes could develop among patients with decompensated cirrhosis. Their prognosis and outcomes for therapy vary significantly. Each AKI type has a unique treatment approach; thus, it\u27s critical to diagnose and initiate therapy for each immediately. Aim of the study: We aimed to determine if fractional excretion of Urea and Sodium (FEUrea and FENa) may be valuable for distinguishing AKI phenotypes. Methods: An observational study was conducted between May 2022–and May 2022. Enrolled in the trial were 50 cirrhotic patients without AKI and 100 cirrhotic patients with AKI. Every patient had a comprehensive clinical evaluation and history taking. Both groups\u27 fractional excretion of urea and sodium was measured (Trial registration number Trial Register NCT0367563). Results: Both studied groups had insignificant differences in terms of demographic data. FEUrea (%) was significantly higher in the AKI patients than in the non-AKI patients, owing to elevated urea levels in the AKI. However, plasma FENa (%) concentration in the non-AKI controls significantly increased compared to that in the AKI patients. Also, FEurea (%) and FENa (%) concentrations were significantly higher in the renal-AKI patients than in those with the pre-renal-AK. FEurea at a cut-off point &gt; 36.6% had 90.9% sensitivity and 86.5% specificity, with the area under the curve (AUC) being 0.911 for the prediction of AKI. In comparison, FENa at a cut-off point &gt; 0.88% had 90.6% sensitivity and 77.5% specificity, with an AUC of 0.986 for the prediction of AKI. Conclusion Both FEurea and FENa can be utilized to predict AKI early. More verified research is needed

Design zigzag edge of S shape slot antenna by using SIW technology for 5G application

This study offers a 5G substrate integrated waveguide (SIW) antenna with vertical S zigzag shape slot. The suggested antenna's radiating patch depends on the shape of the slot. Two types of slots have been used, straight and zigzag S shape slot with vertical and horizontal direction, slots are etched on the patch to increase the antenna's overall bandwidth and gain. The suggested straight and zigzag SIW S slot antennas both resonate at 28 GHz, and the overall structure size is 7.10×14.93 mm. The presented design could achieve high gain, efficiency, and minimal losses, which are all important concerns. The presented antenna may produce a gain of 9.48 dB, a 95% efficiency, and a wider bandwidth of no less than 3.25 GHz at 28 GHz

Effect of Spraying Some Nutrients on Fruiting of Sewy Date palm (Phoenix dactylifera L.) Under New Valley Conditions

This study was carried out during two successive seasons of 2019 and 2020. To evaluate the effect of some nutrients spray on yield and fruit quality of Sewy date palm cultivar grown under El-Kharga Oasis , New Valley conditions. The experiment was set up in a complete randomized block design with ten treatments, using five replicates, bunch each. The data revealed that:- Mega phosphor, omega potas and omega cal-mag spray significantly increased the fruit retention and bunch weight compared to the untreated ones. Omega potas application was more effective compared with omega cal-mag or mega phosphor. - Spraying either mega phosphor, omega potas or omega cal-mag at any studied concentration was accompanied by improving fruit quality in terms of a significant increase in fruit weight, total soluble solids, sugars contents, NPK and beta carotene and significantly decreased in total acidity tannins and phenols compared to control. - The best results were obtained when using 4cm3/L of omega potas or 4cm3/L of omega cal-mag or 4cm3/L of mega phosphor, respectively. Also, no significant differences were found between spraying the two concentrations (2cm3 or 4cm3 of mega phosphor, omega potas and omega cal-mag.Therefore, from the results of the study, it could be concluded that must be sprayed the date bunches with 2 cm3/L of omega potas or 2cm3/L of omega cal-mag to obtain a high yield with good properties, hence, high value marketing