Hallervorden spatz disease – a rare clinicoradiological diagnosis

Hallervorden Spatz disease, also known as pantothenate kinase associated neuro-degeneration, is a rare, progressive neurological disorder usually seen in first decade of life. It is associated with extrapyramidal effects, dysarthria and dementia. Hallervorden Spatz Disease is also associated with psychiatric symptoms, depression and behavioral changes. Affected patients are disabled predominantly by dystonia. MRI, in later stage of the disease, shows “eye of the tiger’ appearance which is fairly diagnostic of Hallervorden Spatz Disease. Response to drugs is often poor and of limited value to these patients. This report highlights a classical case of Hallervorden Spatz disease that presented as an outpatient with dystonia and psychotic symptoms and was diagnosed on the basis of clinical and radiological evidence

Corrosion inhibition mechanism of Piperacillin Sodium for mild steel protection in acidic media

The corrosion inhibition of mild steel in 1M HCl solution by Piperacillin Sodium was studied by weight loss measurement and electrochemical techniques   i.e. Polarization Resistance, Potentiodynamic Polarization and Electrochemical Impedance Spectroscopy (EIS). The results obtainedat 30ºC divulged that this pharmaceutical compound had established 93% inhibition efficiency at an optimum concentration of 7.2×10-4 M. These outcomes show that inhibition takes place by adsorption of the inhibitor on metal surface without altering the mechanism of corrosion process. The adsorption of Piperacillin Sodium takes place according to Langmuir adsorption isotherm. Potentiodynamic polarization studies indicate that Piperacillin Sodium acts as a mixed type of inhibitor. Data collectedfrom EIS studies has been analyzed to model the appropriate equivalent circuit for better explanation of corrosion inhibition process. The inhibition mechanism of Piperacillin Sodium has been discussed

A Bibliometric Analysis of the Top 100 Cited Articles on Hepatic Magnetic Resonance Imaging.

The purpose of this study is to guide the readers to the impact of the articles published on hepatic magnetic resonance imaging (MRI). We searched Scopus using 10 different search terms for hepatic MRI. The selected studies were thoroughly reviewed by two independent authors and any disagreement was sorted out by mutual consensus. The list of articles and journals was downloaded into an excel spreadsheet. Only the top 100 cited articles were selected by mutual consensus among all the authors. These articles were further read in the full-text form and were further categorized into subgroups. Three authors independently reviewed the top 100 selected articles, and subsequently data was extracted from them and analyzed. Our study showed that the highest number of top 100 cited articles on hepatic MRI were from Radiology (30 articles) followed by European Radiology (14 articles). The American Journal of Roentgenology, Radiographics, and Journal of Magnetic Resonance had seven articles each. The United States had the highest number of articles by region. Nineteen other journals contributed only one article each to the list of top 100 cited articles. The contribution of authors to the top 100 cited articles was reviewed; all the authors contributing with more than two articles to the highly cited articles are given in Table 3 in the supplementary material. The maximum number of articles were published during 2009 (14 articles), and for a five-year period, the maximum contribution was made during 2008-2013 (44 articles). Our analysis gives an insight on the frequency of citations of top articles on hepatic MRI, categorizes the subtopics, the timeline of the publications, and contributions from different geographic distributions

SPATA: Strong Pseudonym based AuthenTicAtion in Intelligent Transport System

Intelligent Transport System (ITS) is generally deployed to improve road safety, comfort, security, and traffic efficiency. A robust mechanism of authentication and secure communication is required to protect privacy and conditional resolution of pseudonyms to revoke malicious vehicles. In a typical ITS framework, a station can be a vehicle, Road Side Unit (RSU), or a server that can participate in communication. During authentication, the real identity of an Intelligent Transport System-Station (ITSS), referred to as a vehiclečň should not be revealed in order to preserve its privacy. In this paper, we propose a Strong Pseudonym based AutenTicAtion (SPATA) framework for preserving the real identity of vehicles. The distributed architecture of SPATA allows vehicles to generate pseudonyms in a very private and secure way. In the absence of a distributed architecture, the privacy cannot be preserved by storing information regarding vehicles in a single location. Therefore, the concept of linkability of certificates based on single authority is eliminated. This is done by keeping the real identity to pseudonym mappings distributed. Furthermore, the size of the Certificate Revocation List (CRL) is kept small, as only the most recent revoked communication pseudonyms are kept in the CRL. The privacy of the vehicle is preserved during the revocation and resolution phase through the distributed mechanism. Empirical results show that SPATA is a lightweight framework with low computational overhead, average latency, overhead ratio, and stable delivery ratio, in both sparse and dense network scenarios

Intubation in emergency department of a tertiary care hospital in a low-income

Objective: To study the indications, method, success rate and complications of intubation at the Emergency Department of a private, tertiary care hospital in Karachi, Pakistan.Methods: The case series involved 278 patients above 14 years of age who underwent emergency intubation at the Emergency Department of Aga Khan University Hospital, Karachi between 1998 and 2003. Descriptive statistics were used to compare rapid sequence intubation with crash intubation. The level of significance was p\u3c0.05.Results: Of the total 278 intubations performed, 37 (13.3%) had to be left out for incomplete information. The study population remaining for inferential analysis comprised of 241 patients. Of the total 278 patients, 174 (63%) were males. Rapid sequence intubation was the commonest type (n=185, 67%) of intubation and was performed mostly by anaesthetists (n=236, 85%). Cardiogenic pulmonary oedema and head injury were commonly seen in these patients. The success on first attempt of intubation was 98% (n=181) in rapid sequence intubation, and 85% (n=48) in crash intubation. Overall, 15 (5.3%) complications were seen in these intubations.Conclusion: Study showed a satisfactory success rate in both rapid sequence and crash intubations

Postpartum Care Utilization among Primigravida: A Study in Rural Punjab, Pakistan

The present paper examined some of the socio-economic factors associated with postpartum care utilization among primigravida (first time mothers) in rural Punjab, Pakistan. Data were collected from 205 primigravida within six weeks following their delivery. Maternal education, husband’s education, husband’s occupation, monthly household income and exposure to mass media turned out to be some of the important factors in postpartum care utilization. Antenatal care, type of delivery and place of delivery were significantly associated with the postpartum care services utilization. The findings of the present study clearly underscored the importance of educational attainments of both the spouses in determining the postpartum care utilization. This finding implies that education can help reduce maternal morbidity and mortality. Keywords: Ante-natal care, Postpartum care, Primigravida, Maternal morbidity, Maternal mortalit

Glutathione supplementation in semen extender improves rabbit sperm attributes during refrigeration

[EN] In the present study, we evaluated the sustaining effect of various glutathione (GSH) concentrations in extender on rabbit sperm attributes during storage at 5°C for 24 h. Semen was collected from regular donor rabbit bucks using an artificial vagina and initially evaluated for sperm quality. The qualifying ejaculates were diluted with one of the extenders having 0, 1, 2, 4 or 8 mM GSH, to achieve a final concentration of 1×108 sperm/mL. The extended samples were stored at 5°C for 24 h. Sperm motility, motion kinetics, acrosome integrity and viability were assessed after 3, 6, 12 and 24 h of storage. The results showed that total sperm motility and sperm motion kinetics (oscillation index of the sperm, straightness index and beat cross frequency) were influenced (P<0.05) by glutathione dose and refrigeration time. An interaction of (P<0.05) GSH concentrations and refrigeration time was observed for sperm viability and acrosome reaction rate. In conclusion, the 4 mM GSH supplemented extender’s protective influence was remarkable to maintainrabbit sperm quality for 24 h 5°C.Ahmad, E.; Naseer, Z.; Aksoy, M. (2021). Glutathione supplementation in semen extender improves rabbit sperm attributes during refrigeration. World Rabbit Science. 29(2):81-86. https://doi.org/10.4995/wrs.2021.14759OJS8186292Aksoy M., Lehimcioğlu N.C., Akman O. 2008. Effect of seminal plasma on functional integrity of rabbit sperm membranes during storage at 4°C or freezing. World Rabbit Sci., 16: 1-6.https://doi.org/10.4995/wrs.2008.642Ansari M.S., Rakha B.A., Ullah N., Andrabi S.M.H., Akhter S. 2011. Glutathione addition in tris-citric egg yolk extender improves the quality of cooled buffalo (Bubalus bubalis) bull semen. Pak. J. Zool., 43: 46-55.Bansal A.K., Bilaspuri G.S. 2011. Impacts of oxidative stress and antioxidants on semen functions. Vet. Med. Intl., Article ID 686137. https://doi.org/10.4061/2011/686137Câmara D.R., Mello-Pinto M.M.C., Pinto I.C., Brasil O.O., Nunes J.F., Guerra M.M.P. 2011. Effects of reduced glutathione and catalase on the kinematics and membrane functionality of sperm during liquid storage of ram semen. Small Rumin. Res., 100: 44-49. https://doi.org/10.1016/j.smallrumres.2011.05.010Darin-Bennett A., White I.G. 1977. Influence of the cholesterol content of mammalian spermatozoa on susceptibility to cold-shock. Cryobiology, 14: 466-470. https://doi.org/10.1016/0011-2240(77)90008-6de Lamirande E., Gagnon C. 1995. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Human Reprod., 10: 15-21.https://doi.org/10.1093/humrep/10.suppl_1.15Domingo P., Olaciregui M., González N., De Blas I., Gil L. 2018. Effects of seminal plasma and different cryoprotectants on rabbit sperm preservation at 16°C. Exp. Anim., 67: 413-420. https://doi.org/10.1538/expanim.17-0152Fadl, A., Ghallab, A., Abou-Ahmed, M. 2019. Quality assessment of cryopreserved New Zealand white rabbit spermatozoa in INRA-82 extender containing different cryoprotectants. World Rabbit Sci., 27: 77-83. https://doi.org/10.4995/wrs.2019.10892Fadl A.M., Ghallab A.M., Abou-Ahmed M.M. 2020. Comparison between tris-buffer and INRA-82 extenders on the quality of chilled rabbit spermatozoa. World Rabbit Sci., 28: 13-18. https://doi.org/10.4995/wrs.2020.12287Johinke D., de Graaf S.P., Bathgate R. 2014. Investigation of in vitro parameters and in vivo fertility of rabbit spermatozoa after chilled storage. Anim. Reprod. Sci., 147: 135-143. https://doi.org/10.1016/j.anireprosci.2014.04.014Johinke D., de Graaf S.P., Bathgate R. 2015. The effect of sperm concentration and storage vessel on quercetin-supplemented rabbit semen during chilled storage. Reprod. Dom. Anim. 50: 567-573. https://doi.org/10.1111/rda.12525Luberda Z. 2005. The role of glutathione in mammalian gametes. Reprod. Biol., 5: 5-17.Maya-Soriano M.J., Taberner E., Sabés-Alsina M., Piles M., Lopez-Bejar M. 2015. Absence of beneficial effects on rabbit sperm cell cryopreservation by several antioxidant agents. Zygote, 23: 1-10. https://doi.org/10.1017/S0967199413000270Munsi M.N., Bhuiyan M.M.U., Majumder S., Alam M.G.S. 2007. Effects of exogenous glutathione on the quality of chilled bull semen. Reprod. Dom. Anim., 42: 358-362. https://doi.org/10.1111/j.1439-0531.2006.00789.xNagy S., Sinkovics G., Kovács A. 2002. Viability and acrosome integrity of rabbit spermatozoa processed in a gelatinsupplemented extender. Anim. Reprod. Sci., 70: 283-286.https://doi.org/10.1016/S0378-4320(01)00189-0Naseer Z., Ahmad E., Aksoy M., Epikmen E. 2020. Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits. World Rabbit Sci., 28: 19-27. https://doi.org/10.4995/wrs.2020.12420Oliveira R.A, Piersanti R.L., Wolf C.A., Viu M.A.O., Gambarini M.L. 2014. Glutathione for the freezing of cooled equine semen, using different protocols. Anim. Reprod., 11: 104-109.Peña F.J., Johannisson A., Wallgren M., Rodriguez-Martinez H. 2003. Antioxidant supplementation in vitro improves boar sperm motility and mitochondrial membrane potential after cryopreservation of different fractions of the ejaculate. Anim. Reprod. Sci., 78: 85-98.https://doi.org/10.1016/S0378-4320(03)00049-6Petruska P., Capcarova M., Sutovsky P. 2014. Antioxidant supplementation and purification of semen for improved artificial insemination in livestock species. Turk. J. Vet. Anim. Sci., 38: 643-652. https://doi.org/10.3906/vet-1404-61Prete C.D., Ciani F., Tafuri S., Pasolini M.P., Valle G.D., Palumbo V., Abbondante L., Calamo A., Barbato V., Gualtieri R., Talevi R., Cocchia N. 2018. Effect of superoxide dismutase, catalase, and glutathione peroxidase supplementation in the extender on chilled semen of fertile and hypofertile dogs. J. Vet. Sci., 19: 667-675. https://doi.org/10.4142/jvs.2018.19.5.667Rosato M.P., Di Iorio M., Manchisi A., Gambacorta M., Petrosino G., Centoducati G., Santacroce M. P., Iaffaldano N. 2012. In vitro survival and lipid peroxidation status of rabbit spermatozoa after both chilled and frozen storage in lycopene enriched extenders. Livest. Sci., 146: 199-202. https://doi.org/10.1016/j.livsci.2012.03.006Rosato M.P., Iaffaldano N. 2011. Effect of chilling temperature on the long-term survival of rabbit spermatozoa held either in a trisbased or a jellified extender. Reprod. Dom. Anim., 46: 301-308. https://doi.org/10.1111/j.1439-0531.2010.01667.xSarangi A., Singh P., Virmani M., Yadav A.S., Sahu S., Ajithakumar H.M., Kumari A., Rath A.P. 2017. Effect of antioxidants supplementation on the quality of Beetal buck semen stored at 4°C. Vet. World, 10: 1184-1188. https://doi.org/10.14202/vetworld.2017.1184-1188Saraswat S., Jindal S.K., Kharche S.D. 2016. Antioxidant and spermatozoa: a complex story- A review. Indian J. Anim. Sci., 86: 495-501.Sarıözkan S., Özdamar S., Türk G., Cantürk F., Yay A. 2014. In vitro effects of l-carnitine and glutamine on motility, acrosomal abnormality, and plasma membrane integrity of rabbit sperm during liquid-storage. Cryobiology 68: 349-353. https://doi.org/10.1016/j.cryobiol.2014.04.006Sarıözkan S., Türk G., Cantürk F., Yay A., Eken A., Akçay A. 2013. The effect of bovine serum albumin and fetal calf serum on sperm quality, DNA fragmentation and lipid peroxidation of the liquid stored rabbit semen. Cryobiology, 67: 1-6. https://doi.org/10.1016/j.cryobiol.2013.04.002Yimer N., Kaka A., Yusoff R., Haron A.W. 2016. The roles of antioxidants and fatty acids in sperm cryopreservation. Cryopreservation in Eukaryotes, Francisco Marco-Jiménez and Hülya Akdemir, IntechOpen. https://doi.org/10.5772/65571Zeitoun M.M., Al-Damegh M.A. 2015. Effect of nonenzymatic antioxidants on sperm motility and survival relative to free radicals and antioxidant enzymes of chilled-stored ram semen. Open J. Anim. Sci., 5: 50-58. https://doi.org/10.4236/ojas.2015.51007Zhandi M., Ghadimi V. 2014. Effect of glutathione-supplemented INRA82 extender on miniature Caspian stallion sperm quality during storage at 5C. J. Equine Vet. Sci., 34: 606-610. https://doi.org/10.1016/j.jevs.2013.11.00

Commercial development for a site in downtown Junction City, Kansas

Typescript (photocopy).Department: Architecture